2024, volume 20

Objective: comparative qualitative expert assessment of the condition of the patient's fundus in severe and advanced stages of proliferative diabetic retinopathy (PDR). Material and methods. An assessment was made of the developed qualitative criteria for the condition of the fundus in patients with the following stages of PDR: severe-high risk 1 (SHRPDR-1, 32 eyes), severe-high risk 2 (SHRPDR-2, 32 eyes) and advanced (APDR, 34 eyes). The developed criteria (preretinal hemorrhage, fibrosis of the posterior hyaloid membrane, vitreous hemorrhage, etc.) were assessed by one ophthalmic surgeon on a point scale: 1 point — initial changes; 2 — weak, but more pronounced (compared to 1 point) changes; 3 — severity of moderate changes; 4 — pronounced changes. Results. The greatest increase in the average score in the group of patients with APDR (compared with SHRPDR-1 and SHRPDR-2) was established according to the following criteria: fibrovascular tissue in the area of the optic nerve head and along the vascular arcades (2 times), fibrosis of the posterior hyaloid membrane (1.5 times), vitreous hemorrhage (1.4 times); for other criteria, the increase in average score varies from 28 to 93%. At the same time, there is only a tendency for the criteria to worsen between SHRPDR-1 and SHRPDR-2 (p>0.05). Conclusion. A significant deterioration of all criteria was established in patients with APDR compared with SHRPDR-1 and SHRPDR-2.

Objective: to assess the level of markers of antioxidant protection in women with infertility of unknown origin in comparison with women who gave birth to at least one living child. Material and methods. A comparative cohort retrospective study was conducted, which included 52 women with infertility of unknown origin and 85 women who do not suffer from infertility. In the course of the work, standard biochemical parameters, antioxidant and peroxidase activity were studied. Results. In women with infertility of unknown origin, the total antioxidant activity is more pronounced (2.21±0.312 and 1.97±0.312 ng/ml; p<0.001), however, a low level of peroxidase activity was found (11.6±3.96 and 13.4±6.67%; p<0.001). Conclusion. In our study, it was found that in women with infertility of unknown origin, the level of total antioxidant capacity of serum is higher than in women who have realized their reproductive function, while peroxidase activity is less pronounced.