Molecular biomarkers of glaucoma (review)
Heading: Тhematic supplement Article type: Review
Authors: Kamenskikh I.D., Veselova E.V., Kamenskikh T.G.
Organization: Saratov State Medical University
Abstract. Objective: to analyze the data available in the literature on the possibilities of using molecular biomarkers of glaucoma for early detection of the mechanisms involved in neuronal damage to retinal ganglion cells. The review material was 30 foreign and 10 Russian sources from the medical international databases PubMed, Cochrane and the e-Library electronic library, the electronic search period is 2018-2022. Despite the fact that the diagnosis of glaucoma is based on the clinical picture, the identification of molecular biomarkers of glaucoma may contribute to its earlier diagnosis and the development of new approaches to monitoring and drug therapy.
Bibliography:
1. Beykin G, Goldberg JL. Molecular biomarkers for glaucoma. Curr Ophthalmol Rep. 2019; (7): 171-6. DOI: 10.1007/S40135-019-00213-0.
2. Bua S, Supuran CT. Diagnostic markers for glaucoma: A patent and literature review (2013-2019) Expert Opin Ther Pat. 2019; (29): 829-39. DOI: 10.1080/13543776.2019.1667336.
3. Beykin G, Norcia AM, Srinivasan VJ, et al. Discovery and clinical translation of novel glaucoma biomarkers. Prog Re-tin Eye Res. 2021; (80): 100875. DOI: 10.1016/j.preteyeres. 2020.100875.
4. Aghamollaei H, Parvin S, Shahriary A. Review of pro-teomics approach to eye diseases affecting the anterior segment. J Proteom. 2020; (225): 103881. DOI: 10.1016/j.jprot. 2020.103881.
5. Ahmad A, Ahsan H. Biomarkers of inflammation and oxi-dative stress in ophthalmic disorders. J Immunoass Immunochem. 2020; (41): 257-71. DOI: 10.1080/15321819.2020.1726774.
6. Kennedy SM, Sheridan C, Kearns VR, et al. Thrombo-spondin-2 is up-regulated by TGFP2 and increases fibronectin expression in human trabecular meshwork cells. Exp Eye Res. 2019; (189): 107820. DOI: 10.1016/j.exer.2019.107820.
7. Svinareva Dl. The contribution of gene-gene interactions of polymorphic loci of matrix metalloproteinases to susceptibility to primary open-angle glaucoma in men. Research Results in Biomedicine. 2020; 6 (1): 63-77.
8. Markova EV, Baranov VI, Danilenko ОА. The role of immunological mechanisms in the development and progressing of endothelial dysfunction in patients with pseudoexfoliation glaucoma. Medical Bulletin of Bashkortostan. 2018; 1 (3): 65-8.
9. Guo Т, Guo L, Fan Y, Fang L, et al. Aqueous humor levels of TGF-P2 and SFRP1 in different types of glaucoma. ВМС Ophthalmol. 2019; (19): 1-9. DOI: 10.1186/s12886-019-1183-1.
10. Igarashi N, Honjo M,Asaoka R, et al. Aqueous autotaxin and TGF-ps are promising diagnostic biomarkers for distinguishing open-angle glaucoma subtypes. Sci Rep. 2021; 11 (1): 1408. DOI: 10.1038/S41598-021-81048-3.
11. Fomin NE, Kuroyedov AV. Markers of vascular auto-regulation in primary open-angle glaucoma. Russian Journal of Clinical Ophthalmology. 2019; 19 (4): 218-23.
12. ten Berge JC, Fazil Z, van den Born I, et al. Intraocular cytokine profile and autoimmune reactions in retinitis pigmen-tosa, age-related macular degeneration, glaucoma and cataract. Acta Ophthalmol. 2019; (97): 185-92. DOI: 10.1111/aos.13899.
13. Sun C, Zhang H, Tang Y, et al. Aqueous inflammation and ischemia-related biomarkers in neovascular glaucoma with stable iris neovascularization. Curr Eye Res. 2020; (45): 1504-13. DOI: 10.1080/02713683.2020.1762226.
14. Nezu N, Usui Y, Saito A, et al. Machine learning approach for intraocular disease prediction based on aqueous humor immune mediator profiles. Ophthalmology. 2021. 128 (8): 1197-208. DOI: 10.1016/j.ophtha.2021.01.019.
15. Sakhnov SN, Kharchenko VV. Diagnosis and prognosis of glaucoma. Clinical laboratory diagnostics. 2018; (4): 246-9.
16. Agarkov NM, Chukhraev AM, Yablokova NV. Diagnosis and prediction ofprimary open-angle glaucoma by the level of local cytokine. Medical Immunology (Russia)/Meditsinskaya Im-munologiya. 2019; 21 (6): 1163-8.
17. Rakhmanov VV, Sokolov Dl, Selkov SA, et al. Role of cytokines in the pathogenesis of glaucoma. Annals of the Russian Academy of Medical Sciences. 2020; 75 (6): 609-16. DOI: 10.15690/vramn1289.
18. Burgos-Blasco В, Vidal-Villegas В, Saenz-Frances F, et al. Tear and aqueous humour cytokine profile in primary open-angle glaucoma. Acta Ophthalmol. 2020; 98 (6): e768-72. DOI: 10.1111/aos.14374.
19. Lin JB, Sheybani A, Santeford A, et al. Increased aqueous humor gdf15 is associated with worse visual field loss in pseudoexfoliative glaucoma patients. Transl Vis Sci Technol. 2020; (9): 1-6. DOI: 10.1167/tvst.9.10.16.
20. Can Demirdogen B, Kocan Akcin C, Ozge G, Mumcuoglu T. Evaluation of tear and aqueous humor level, and genetic variants of connective tissue growth factor as biomarkers for early detection of pseudoexfoliation syndrome/glaucoma. Exp Eye Res. 2019; (189): 107837. DOI: 10.1016/j.exer. 2019.107837.
21. Wang J, Fu M, Liu K, et al. Matricellular proteins play a potential role in acute primary angle closure. Curr Eye Res. 2018; 43 (6): 771-7. DOI:10.1080/02713683.2018.1449222.
22. Ishikawa K, Kohno Rl, Mori K, et al. Increased expression of periostin and tenascin-C in eyes with neovascular glaucoma secondary to PDR. GraefesArch Clin Exp Ophthalmol. 2020; 258 (3): 621-8. DOI:10.1007/s00417-019-04574-x.
23. Basu K, Maurya N, Kaur J, et al. Possible role of differentially expressing novel protein markers (ligatin and fibulin-7) in human aqueous humor and trabecular meshwork tissue in glaucoma progression. Cell Biol Int. 2019; 43 (7): 820-34. DOI: 10.1002/cbin.11138.
24. Can Demirdogen B, Demirkaya-Budak S, Ozge G, Mumcuoglu T. Evaluation of tear fluid and aqueous humor concentration of clusterin as biomarkers for early diagnosis of pseudoexfoliation syndrome and pseudoexfoliative glaucoma. Curr Eye Res. 2020; 45 (7): 805-13. DOI: 10.1080/02713683.2019. 1698055.
25. Adav SS, Wei J, Terence Y, et al. Proteomic analysis of aqueous humor from primary open angle glaucoma patients on drug treatment revealed altered complement activation cascade. J Proteome Res. 2018; 17 (7): 2499-510. DOI: 10.1021/acs. jproteome.8b00244.
26. Buisset A, Gohier P, Leruez S, et al. Metabolomic profiling of aqueous humor in glaucoma points to taurine and sperm-ine deficiency: Findings from the Eye-D study. J Proteome Res. 2019; 18(3): 1307-15. DOI: 10.1021/acs.jproteome.8b00915.
27. Barbosa Breda J, Croitor Sava A, Himmelreich U, et al. Metabolomic profiling of aqueous humor from glaucoma
patients the metabolomics in surgical ophthalmological patients (MISO) study. Exp Eye Res. 2020; (201): 108268. DOI: 10.1016/j.exer. 2020.108268.
28. Chen X, Chen Y, Wang L, Sun X. Metabolomics of the aqueous humor in patients with primary congenital glaucoma. Mol Vis. 2019; (25): 489-501.
29. Pan CW, Ke C, Chen Q, et al. Differential metabolic markers associated with primary open-angle glaucoma and cataract in human aqueous humor. ВМС Ophthalmol. 2020; 20 (1): 183. DOI: 10.1186/sl 2886-020-01452-7.
30. Beutgen VM, Perumal N, Pfeiffer N, Grus FH. Autoanti-body biomarker discovery in primary open angle glaucoma using serological proteome analysis (SERPA) Front Immunol. 2019; (10): 381. DOI: 10.3389/fimmu.2019.00381.
31. Gabdrakhmanova AF, Aznabaeva LF, Kurbanov SA, Abizgil'dina GS. Molecular mechanisms of neurodegeneration in primary open-angle glaucoma. Bashkortostan Medical Journal. 2018; 13 (1): 61-5.
32. Igarashi Т, Nakamoto К, Kobayashi М, et al. Serum brain-derived neurotrophic factor in glaucoma patients in Japan: An observational study. J Nippon Med Sch. 2020; 87 (6): 339-345. DOI: 10.1272/jnms.JNMS.2020_87-605.
33. Gabdrakhmanova AF, Gainutdinova RF, Aznabaeva LF, et al. Neuronal markers of primary open-angle glaucoma. Practical Medicine. 2018; 3 (114): 48-51.
34. Cherednichenko NL, Karpov SM, Baturin VA, Barbos YuA. Antibodies to myelin basic protein as a diagnostic marker of primary open-angle glaucoma. Ophthalmology Journal. 2018; 11 (1): 19-24.DOI: 10.17816/OV11119-24.
35. Pitts KM, Neeson СЕ, Hall NE, et al. Neurodegeneration markers galectin-3 and apolipoprotein E are elevated in the aqueous humor of eyes with glaucoma. Transl Vis Sci Technol. Transl Vis Sci Technol. 2022; 11 (11): 1. DOI: 10.1167/tvst. 11.11.1.
36. Beletskaya IS, Astakhov SYu, Karonova TL, et al. Pseudoexfoliative glaucoma and molecular genetic characteristics of vitamin D metabolism. Ophthalmology Journal. 2018; 11 (2): 19-28.
37. Vohra R, Dalgaard LM, Vibaek J, et al. Potential metabolic markers in glaucoma and their regulation in response to hy-poxia. Acta Ophthalmol. 2019; 97 (6): 567-76. DOI: 10.1111/aos. 14021.
38. Tokuc EO, Yuksel N, Kir HM, Acar E. Evaluation of serum and aqueous humor klotho levels in pseudoexfoliation syndrome, pseudoexfoliation and primary open-angle glaucoma. Int Ophthalmol. 2021; 41 (7): 2369-75. DOI: 10.1007/s10792-021 -01790-5.
39. Dalgaard LM, Vibask J, Vohra R, et al. Enhanced physiological stress response in patients with normal tension glaucoma during hypoxia. J Ophthalmol. 2021; 2021: 5826361. DOI: 10.1155/2021/5826361.
40. Kouassi Nzoughet J, Guehlouz K, Leruez S, et al. A data mining metabolomics exploration of glaucoma. Metabolites. 2020; 10 (2): 49. DOI: 10.3390/metabo10020049.
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