Characterization of changes in cellular renewal and apoptosis of gingival epithelium in patients with chronic generalized periodontitis in the postmenopausal period
Year: 2022, volume 18 Issue: №3 Pages: 319-322
Heading: Stomatology Article type: Original article
Authors: Ismailova O.A., Eremina N.V., Strukov V.I., Vichrev D.V.
Organization: Penza Institute for Further Training of Physicians — Branch Campus of the Russian Medical Academy of Continuous Professional Education
Heading: Stomatology Article type: Original article
Authors: Ismailova O.A., Eremina N.V., Strukov V.I., Vichrev D.V.
Organization: Penza Institute for Further Training of Physicians — Branch Campus of the Russian Medical Academy of Continuous Professional Education
Summary:
Objective: determination of the nature of violation processes of proliferation and apoptosis in gum epithelium women have in the postmenopausal period with different degree of bone mineralization for early diagnostics and optimization of complex therapy. Material and methods. There has been examination of 80 women aged 55-60 у о. with chronic generalized periodontitis (CGP) and decreased bone mineral density (BMD). All patients got standard dental examination, including index evaluation of periodontal tissues. Quantitative evaluation of BMD was held with use of densitometric analysis of state of bone tissue. Studying the indicators of cell renewal was held with help of immunohistochemical examination. Results. As a result of the conducted research, it was found that patients with CGP and BMD violations had a reduce of proliferation of gum epithelial cells with their apoptosis activation апоптоза (lapt=0.73±0.03%, Iki-67=11.77±0.27%) compared with patients with intact periodontium (lapt 0.29±0.04%, lki-67=9.88±0.09%) at p=0.04. Conclusion. As a result of the conducted research, it was found that patients in the postmenopausal period have CGP with increasing activity of gum epithelial cells apoptosis amid falling their cell proliferation indicators. The patients' inflammatory and destructive processes activity in periodontal tissues is higher amid osteopenia comparing with patients without violation of BMD.
Keywords: chronic generalized periodontitis, lapt, lki-67, postmenopausal osteopenia, proliferation and apoptosis of gingival epithelial cells
Bibliography:
1. Atrushkevich VG, Polyakov AV, Zinovieva Al, et al. Genetically determined violation of mineral metabolism as a risk factor for the development of chronic generalized periodonti-tis with aggressive course. Health and Education Millennium 2012; 14 (5): 28-9.
2. Suetenkov DE, Petrova АР, Zobnin KYu, et al. Regenerative medicine and dentistry. Sechenov Medical Journal 2017; 1 (27): 4-9.
3. Ostrovskaya LY, Bulkina NV, Vedyaeva АР. Prognostic value of neuroendocrine system indicators in the development of peri-odontal pathology against the background of peptic ulcer disease. Morphology 2018; 153 (3): 210-10a.
4. Ismailova ОА, Eremina NV, Strukov VI, et al. Clinical and pathogenetic features of chronic generalized peri-odontitis in menopausal women depending on morphomet-ric manifestations of bone tissue and complex therapy with Osteomed Forte. Vrach (The Doctor) 2019; (5): 40-3.
5. Richa RY, Puranik МР, Shrivastava A. Association between osteoporosis and periodontal disease among postmeno-pausal Indian women. J Investig Clin Dent 2017; 8 (3): 34-8.
6. Wang CJ, Mc Cauley LK. Osteoporosis and Periodonti-tis. CurrOsteoporos2016; 14(6): 284-91.
7. Adam M, Wooton J. Menopause end oral health. Br Dent J 2022; 233 (3): 170.
8. Ayed MS, Alsharif AF, Divakar DD, et al. Evaluating the possible association between systemic osteoporosis and periodontal disease progression in postmenopausal women. Dis Mon2019;65(6): 193-215.
9. Bulkina NV, Osipova YuL. Clinical and immunomorpho-logical features of the course of chronic generalized periodontitis against the background of gastroesophageal reflux disease. Fundamental Research 2012; 5 (1): 213-6.
10. Osipova YuL, Bulkina NV, OsadchukMA, etal.The role of cellular proliferation and apoptosis disorders in the pathogenesis of inflammatory periodontal diseases against the background of gastroesophageal reflux disease. Saratov Journal of Medical Scientific Research 2013; 9 (3): 449-53.
11. Speranskaya ЕМ, Mukhamedzhanova LR, Golubtso-va NN. Morphological assessment of the activity of prolifera-tive processes in periodontal tissues in patients with chronic generalized periodontitis. Acta medica Eurasica 2017; (1): 55-9.
12. Methods of comprehensive examination of patients with diseases periodontal disease. In: Periodontology. Series: National guidelines. Moscow: GEOTAR-Media, 2018; p. 187-255.
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