

Visceral obesity: key risk factors and diagnostic aspects (review)
Heading: Cardiology Article type: Review
Authors: Dzhioeva O.N., Angarsky R.K., Shvartz E.N., Kiselev A.R., Drapkina O.М.
Organization: National Research Centre for Therapy and Preventive Medicine, Saratov State Medical University
Objective; to discuss the current views on the risk factors and diagnostic methods of visceral obesity in the aspect of prevention of cardiovascular complications. The review is done using the PRISMA method. Mainly publications from five electronic databases (Scopus, PubMed, Web of Science, Google Scholar and e-Library) from 1980 to 2021 were analyzed using the following keywords and their combinations: "visceral obesity", "risk factors", "diagnosis", "body mass index", "waist circumference", "ectopic adipose tissue", and "cardiovascular complications". In addition, the review includes selected archival publications of principal scientific significance. As a result, the review includes 37 most significant publications for the disclosure of the above-mentioned topic. The combined use of such parameters as body mass index, waist circumference and fasting triglyceride level has been shown to be reasonable in the diagnosis of visceral obesity. In addition, radiological and ultrasound techniques of visceral obesity assessment are being introduced into clinical practice.
Bibliography:
1. Koenen M, Hill MA, Cohen P, et al. Obesity, adipose tissue and vascular dysfunction. Circ Res 2021; 128(7): 951-68.
2. Mead E, Brown T, Rees K, et al. Diet, physical activity and behavioural interventions for the treatment of overweight or obese children from the age of 6 to 11 years. Cochrane Database Syst Rev 2017; (6): CD012651.
3. Stefan N, Haring H-U, Hu FB, et al. Metabolically healthy obesity: Epidemiology, mechanisms, and clinical implications. Lancet Diabetes Endocrinol 2013; (1): 152-62.
4. Nedungadi TP, Clegg DJ. Sexual dimorphism in body fat distribution and risk for cardiovascular diseases. J Cardiovasc Transl Res 2009; 2 (3): 321-7.
5. Kvist H, Chowdhury B, Grangard U, et al. Total and visceral adipose-tissue volumes derived from measurements with computed tomography in adult men and women: predictive equations. Am J Clin Nutr 1988; (48): 1351 -61.
6. Elbers JM, Giltay EJ, Teerlink T, et al. Effects of sex steroids on components of the insulin resistance syndrome in transsexual subjects. Clin Endocrinol 2003; (58): 562-71.
7. Rice T, Perusse L, Bouchard C, Rao DC. Familial clustering of abdominal visceral fat and total fat mass: the Quebec family study. Obes Res 1996; (4): 253-61.
8. Speliotes EK, Wilier CJ, Berndt SI. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet 2010; (42): 937-48.
9. Wedell-Neergaard AS, Krogh-Madsen R, Petersen GL, et al. Cardiorespiratory fitness and the metabolic syndrome: Roles of inflammation and abdominal obesity. PLoS One 2018; 13 (3):e0194991.
10. Nicolaides NC, Kyratzi E, Lamprokostopoulou A, et al. Stress, the stress system and the role of glucocorticoids. Neuroimmunomodulation 2015; 22 (1-2): 6-19.
11. Nettleton JA, Follis JL, Ngwa JS, et al. Gene x dietary pattern interactions in obesity: Analysis of up to 68317 adults of european ancestry. Hum Mol Genet 2015; 24 (16): 4728-38.
12. Qi Q, Chu AY, Kang JH, et al. Sugar-sweetened beverages and genetic risk of obesity. N Engl J Med 2012; (367): 1387-96.
13. Hruby A, Manson JE, Qi L, et al. Determinants and consequences of obesity. Am J Public Health 2016; (106): 1656-62.
14. Guallar-Castillon P, Rodriguez-Artalejo F, Fornes NS, et al. Intake of fried foods is associated with obesity in the cohort of Spanish adults from the European prospective investigation into cancer and nutrition. Am J Clin Nutr 2007; 86 (1): 198-205.
15. Kilpelainen TO, Qi L, Brage S, et al. Physical activity attenuates the influence of FTO variants on obesity risk: A meta-analysisof218,166 adults and 19,268 children. PLoS Med 2011; (8): e1001116.
16. Qi Q, Li Y, Chomistek AK, et al. Television watching, leisure time physical activity, and the genetic predisposition in relation to body mass index in women and men. Circulation 2012; (126): 1821-7.
17. Tyrrell J, Wood AR, Ames RM, et al. Gene-obesogenic environment interactions in the UK biobank study. Int J Epidemiol 2017; 46 (2): 559-75.
18. Celis-Morales C, Lyall DM, Guo Y, et al. Sleep characteristics modify the association of genetic predisposition with obesity and anthropometric measurements in 119,679 UK biobank participants. Am J Clin Nutr 2017; 105 (4): 980-90.
19. Samorodskaya IV. Body mass index and the obesity paradox. Russian Medical Journal 2014; (2): 170.
20. Doyle SL, Donohoe CL, Lysaght J, et al. Visceral obesity metabolic syndrome, insulin resistance and cancer. Proc Nutr Soc2012; (71): 181-9.
21. Britton KA, Massaro JM, Murabito JM, et al. Body fat distribution, incident cardiovascular disease, cancer, and all-cause mortality. J Am Coll Cardiol 2013; (62): 921-5.
22. Thomas EL, Frost G, Taylor-Robinson SD, et al. Excess body fat in obese and normal-weight subjects. Nutr Res Rev 2012; (25): 150-61.
23. Drapkina OM, Kim ОТ Epigenetics of obesity. Cardiovascular Therapy and Prevention 2020; 19 (6): 2632.
24. Lapidus L, Bengtsson С, Larsson В, et al. Distribution of adipose tissue and risk of cardiovascular disease and death: A 12 year follow up of participants in the population study of women in Gothenberg, Sweden. Br Med J 1984; (289): 1257-61.
25. Larsson B, Svardsudd K, Welin L, et al. Abdominal adipose tissue distribution, obesity, and risk of cardiovascular disease and death: 13 year follow up of participants in the study of men born in 1913. BMJ 1984; (288): 1401-4.
26. Thomas EL, Fitzpatrick JA, Malik SJ, et al. Whole body fat: content and distribution. Prog Nucl Magn Reson Spectrosc 2013; (73): 56-80.
27. Matsuzawa Y, Funahashi T, Nakamura T. The concept of metabolic syndrome: contribution of visceral fat accumulation and its molecular mechanism. J Atheroscler Thromb 2011; (18): 629-39.
28. Aung K, Lorenzo C, Hinojosa MA, Haffner SM. Risk of developing diabetes and cardiovascular disease in metabolically unhealthy normal-weight and metabolically healthy obese individuals. J Clin Endocrinol Metab 2014; 99 (2): 462-8.
29. Vague J. La differenciation sexuelle: facteur determinant des formes de I'obesite. Presse Med 1947; (30): 339-40.
30. Vague J. The degree of masculine differentiation of obesities: a factor determining predisposition to diabetes, atherosclerosis, gout, and uric calculous disease. Am J Clin Nutr 1956; (4): 20-34.
31. Krotkiewski M, Bjbrntorp P, Sjostrom L, et al. Impact of obesity on metabolism in men and women. Importance of regional adipose tissue distribution. J Clin Invest 1983; (72): 1150-62.
32. Ohlson LO, Larsson B, Svardsudd K, et al. The influence of body fat distribution on the incidence of diabetes mellitus. 135 years of follow-up of the participants in the study of men born in 1913. Diabetes 1985; (34): 1055-8.
33. Tokunaga K, Matsuzawa Y, Ishikawa K, Tarui S. A novel technique for the determination of body fat by computed tomography. Int J Obes 1983; (7): 437-45.
34. Ramos-Lopez O, Riezu-Boj Jl, Milagro Fl, et al. Prediction of blood lipid phenotypes using obesity-related genetic polymorphisms and lifestyle data in subjects with excessive body weight. Int J Genomics 2018; (2018): 4283078.
35. Chaston ТВ, Dixon JB. Factors associated with percent change in visceral versus subcutaneous abdominal fat during weight loss: findings from a systematic review. Int J Obes 2008; (32): 619-28.
36. Mahabadi AA, Massaro JM, Rosito GA, et al. Association of pericardial fat, intrathoracic fat, visceral abdominal fat with cardiovascular disease burden: the Framingham Heart Study. Eur Heart J 2009; (30): 850-6.
37. Ludescher B, Machann J, Eschweiler GW, et al. Correlation of fat distribution in whole body MRI with generally used anthropometric data. Invest Radiol 2009; (44): 712-9.
38. Kullberg J, Brandberg J, Angelhed JE, et al. Whole-body adipose tissue analysis: comparison of MRI, CT, and dual energy X-ray absorptiometry. Br J Radiol 2009; (82): 123-30.
39. Silver HJ, Niswender KD, Kullberg J, et al. Comparison of gross body fat-water magnetic resonance imaging at 3 Tesla to dual-energy X-ray absorptiometry in obese women. Obesity (Silver Spring) 2013; 21 (4): 765-74.
40. Ahmed B, Sultana R, Greene MW. Adipose tissue and insulin resistance in obese. Biomed Pharmacother 2021; (137): 111315.
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