Saratov JOURNAL of Medical and Scientific Research

Dysregulation of the cytokine network in patients with multiple sclerosis

Year: 2022, volume 18 Issue: №1 Pages: 125-127
Heading: Тhematic supplement Article type: Short message
Authors: Melamud M.M., Ermakov Е.А., Boiko A.S., Kamaeva D.A., Ivanova S.A., Nevinsky G.A., Buneva V.N.
Organization: Institute of Chemical Biology and Fundamental Medicine Siberian Branch of the RAS, Mental Health Research Institute, Tomsk

Objective: to evaluate changes in the concentration of 41 cytokines in patients with multiple sclerosis (MS) in comparison with healthy donors (HD). Material and methods. For the study, 55 blood serum samples from MS patients and 36 from healthy donors were used. The concentration of 41 cytokines was determined using a Human Cytokine/Chemokine Magnetic Bead Panel (HCYTMAG-60K-PX41) manufactured by Merck Millipore (Darmstadt, Germany). Statistical analysis of the obtained results (Mann —Whitney l/-test, Bonferroni correction for multiple hypothesis testing) was carried out in Origin 2021. Results. Of the 41 cytokines studied, the concentration of 12 was significantly lower than in healthy donors: GRO (p=0.003); MDC, Eotaxin (p=0.002); EGF, PDGF-AA, TGF-a, PDGF-AB/BB, VEGF, IL-8, MIP-1b, MCP-1, sCD40L (p<0.001), other cytokines did not change significantly. Conclusion. In patients with MS, a decrease in the concentration of twelve cytokines was found compared with HD. Altered cytokines can be classified into two functional groups: growth factors and "monocyte-macrophage" cytokines.

1. Wagner С, Roque P, Goverman J. Pathogenic T cell cytokines in multiple sclerosis. J Exp Med 2020; 217 (1): e20190460.
2. Bai Z, Chen D, Wang L, et al. Cerebrospinal fluid and blood cytokines as biomarkers for multiple sclerosis: a systematic review and meta-analysis of 226 studies with 13,526 multiple sclerosis patients. Front Neurosci 2019; (13): 1026.
3. Bixler S, Goff A. The Role of Cytokines and Chemokines in Filovirus Infection. Viruses 2015; 7 (10): 5489-5507.
4. Kallaur A, Oliveira S, Colado A, et al. Cytokine profile in relapsing-remitting multiple sclerosis patients and the association between progression and activity of the disease. Mol Med Rep 2013; 7(3): 1010-20.

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