Saratov JOURNAL of Medical and Scientific Research

The impact of COVID-19 on the state of the medulla oblongata structures: clinical and morphological analysis

Year: 2022, volume 18 Issue: №1 Pages: 122-125
Heading: Тhematic supplement Article type: Original article
Authors: Kuznetsova Е.В., Napsheva A.M., Kolokolov O.V., Zubriychuk A.S., Titarenko D.O.
Organization: Saratov State Medical University

Objective: to conduct a clinical and morphological analysis of the state of the medulla oblongata of patients who died from an infection caused by SARS-CoV-2. Material and methods. The work is based on a morphological study of the medulla oblongata of 10 patients who died from the coronavirus infection COVID-19, who did not appear symptoms and signs of damage to the nervous system during their lifetime, with the exception of ageusia. Results. In the structure of neurons in the medulla oblongata, changes characteristic of infectious diseases (the "mulberry" phenomenon, chromatolysis, eosinophilic inclusions of a protein nature) were revealed. Conclusion. The results obtained indicate that when SARS-CoV-2 enters the brain structures, it triggers the process of destruction of the nuclei of neurons and the penetration of viral inclusions into the cell, which indicates a lesion of the central nervous system directly associated with SARS-CoV-2.

1. Belopasov VV, Yachou Ya, Samoilova EM, Baklau-shev VP. The nervous system damage in COVID-19. Journal of Clinical Practice 2020; 11 (2): 60-80.
2. Ekusheva EV, Kovalchuk VV, Shhukin IA. Neurological complications of COVID-19 and post-covid syndrome. Moscow: AST 345 LLC, 2022; 104 p.
3. Synowiec A, Szczepanski A, Barreto-Duran Е, et al. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2): a systemic infection. Clin Microbiol Rev 2021; (34): e00133-20.
4. Voitenkov VB, Ekusheva EV. Concerning the neurotropy and neuroinvasiveness of coronaviruses. Journal of Clinical Practice 2020; 11 (2): 81-6.
5. Heneka МТ, Golenbock D, Latz Е, et al. Immediate and long-term consequences of COVID-19 infections for the development of neurological disease. Alzheimers Research & Therapy 2020; 12(1): 69.
6. Arbour N, Cote G, Lachance C,etal. Acute and persistent infection of human neural cell lines by human coronavirus OC43. J Virol 1999; (73): 3338-50.
7. Mao L, Jin H, Wang M, et al. Neurologic manifestations of hospitalized patients with coronavirus disease 2019 in Wuhan, China. JAMA Neurol 2020; (77): 683.
8. Helms J, Kremer S, Merdji H, et al. Neurologic features in severe SARS-CoV-2 infection. N Engl J Med 2020; (382): 2268-70.

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