Experimental testing of the target delivery system of tannic acid for periodontal microcirculation correction
Year: 2021, volume 17 Issue: №3 Pages: 494-500
Heading: Рathophysiology Article type: Original article
Authors: Savkina А.А., Lengert E.V., Ermakov A.V., Popykhova Е.В., Stepanova T.V., Ivanov A.N.
Organization: Saratov State Medical University
Heading: Рathophysiology Article type: Original article
Authors: Savkina А.А., Lengert E.V., Ermakov A.V., Popykhova Е.В., Stepanova T.V., Ivanov A.N.
Organization: Saratov State Medical University
Summary:
Objective: to study the effect of the targeted delivery system based on tannic acid within silver alginate framework microcapsules on the gums microvasculature state in rats with intact periodontium and with experimental model peri-odontitis. Material and Methods. The studies were carried out using 90 white rats, divided into six groups, including a control group, 2 groups with intact periodontium, a gel with microcapsules not loaded and loaded with tannic acid was applied once, a group of rats with experimental periodontitis, 2 groups of animals with periodontitis, which were applied gel with microcapsules, without tannic acid and with its loading. In animals, gingival perfusion and blood flow modulation mechanisms were assessed using laser Doppler flowmetry. Results. Application of a gel containing silver microcapsules to an intact gum in rats causes a 7.5% transient increase in perfusion and activation of microcirculation modulation. Loading the microcapsules with tannin acid reduces the severity of transient changes in microcirculation. The use of a gel with capsules loaded with tannic acid in rats with periodontitis makes it possible to achieve a more pronounced normalization of perfusion and mechanisms of microcirculation modulation than the use of a gel containing microcapsules without active components. Conclusion. Loading of alginate microcapsules with silver ions and tannic acid allows reducing the irritating effect on the gingival mucosa accompanied by increase in the efficiency of microcir-culatory disorders correction in experimental model periodontitis.
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