№3, 2020, volume 16

Arterial hypertension refers to multifactorial pathology. Both environmental factors and genetic risk factors contribute to its development. One of the promising areas for the early diagnosis and prevention of hypertension may be the identification of genes whose mutations predispose to its development. The review analyzes the works published for the period 2010-2020 (38 scientific papers), devoted to the molecular genetic basis of the development of arterial hypertension and identifying the possible role of polymorphism of the renin-angiotensin-aldosterone system genes in the genesis of hypertension. The search for sources was carried out in the databases PubMed®, Scopus®, EBSCOhost, Medline, eLIBRARYRU.

Aim: To examine the features of the clinical and anamnestic status and parameters of transthoracic echocardiogra-phy in patients depending on the development of perioperative AF during abdominal noncardiac surgery. Material and Methods: A cohort study. Data from 102 patients was analyzed. The median age was 66 (60; 74), for men —42.2% and 57.8% for women. Results: PeOAF was observed in 37.25% of all studied medical histories. In the group of patients with PeOAF was marked by greater body mass index (p=0.053). In the group with PeOAF it was observed a statistically significant lower value of glomerular filtration rate (p=0.001). Of the comorbidities in the PeOAF group, CHD, diabetes mellitus, and COPD were significantly more common (p<0.001). In patients who were transferred to insulin therapy in the perioperative period, PeOAF was also significantly more frequent. Obtained statistically significant differences (p=0.019) in the development PeOAF in various techniques of surgical intervention: at laparotomy PeOAF marked more often. According to Echo data revealed that in terms of research alone, intraoperatively and in the postoperative period in the group of patients with PeOAF significantly differed from patients without PeOAF all the parameters of intracardiac hemodynamics. Conclusion: In the group of patients with PeOAF at rest, a statistically significant lower LV FV was observed; increased values of linear LV dimensions, LV diastolic filling index, the diameter of the inferior Vena cava, and calculated systolic pressure in the pulmonary artery.

Purpose: To substantiate the possibility of using frequency hearing research in the web application "Automated system of primary hearing assessment". Material and Methods: The study was conducted in the Department of Otorhinolaryngology of Clinics of Samara State Medical University in October 2019. It involved 91 patients aged 17 to 73 years (mean age 48±14.6 years). All participants in the study were divided into two age groups: group I — 17-59 years old, group II — over 60 years old. Patients were asked to pass a hearing assessment in two ways: on the Interacoustics AC-40 clinical audiometer and the web application "Automated system for primary hearing assessment" developed by us (patent no. 2019664671). Results: The maximum difference in average hearing thresholds between tonal threshold audiometry and the web application in group I was 3.3 dB at 2 kHz on the right and 3.2 dB at 2 and 4 kHz on the left, in group II-4.7 and 3.5 dB at 1 and 2 kHz on the right, and 7.2 dB at 4 kHz on the left. The presented data were evaluated using the Cohen Kappa coefficient and confirm a high level of correspondence between the results obtained using the clinical audiometer and the developed web application. Conclusion: Based on the results obtained, a conclusion is made about the possibility of using a web application for primary rapid diagnostics of hearing in General medical practice in conditions of difficult accessibility of audiological care.

The review analyzes the published data on the role of various neurotransmitters, hormones involved in the formation and disturbance of eating behavior. To search for articles, the PubMed database was used, as well as the archives of the journals "Pediatrician", "Medicine: theory and practice" Environment and Energy Science", "Problems of Endocrinology", "Modern Technologies in Medicine", "Russian Journal of Cardiology", "Universum: Medicine and Pharmacology", "Questions of Children's Dietetics", Kursk Scientific and Practical Bulletin "Man and His Health". The literature review used 49 literature sources; articles were published in the period from 2004 to 2020.