Saratov JOURNAL of Medical and Scientific Research

Neuroendocrine mechanisms of regulation of eating behavior (review)

Year: 2020, volume 16 Issue: №3 Pages: 707-713
Heading: Endocrinology Article type: Review
Authors: Bolotova N.V., Kurdiyan M.S., Filina N.Yu.
Organization: Saratov State Medical University

The review analyzes the published data on the role of various neurotransmitters, hormones involved in the formation and disturbance of eating behavior. To search for articles, the PubMed database was used, as well as the archives of the journals "Pediatrician", "Medicine: theory and practice" Environment and Energy Science", "Problems of Endocrinology", "Modern Technologies in Medicine", "Russian Journal of Cardiology", "Universum: Medicine and Pharmacology", "Questions of Children's Dietetics", Kursk Scientific and Practical Bulletin "Man and His Health". The literature review used 49 literature sources; articles were published in the period from 2004 to 2020.

1. Baranov AA. Preventive Pediatrics: A Guide for Physicians. M.: Pediatric, 2015; 744 p.
2. Van Galen КА, Тег Horst KW, Booij J, et al. The role of central dopamine and serotonin in human obesity: lessons learned from molecular neuroimaging studies. Metabolism 2018; (85): 325-39.
3. Naef L, Pitman KA, Borgland SL. Mesolimbic dopamine and its neuromodulators in obesity and binge eating. CNS Spectr 2015; 20 (6): 574-83.
4. Kumar M, Chail M. Sucrose and saccharin differentially modulate depression and anxiety-like behavior in diabetic mice: exposures and withdrawal effects. Psychopharmacology (Berl) 2019; 236 (11): 3095-110.
5. McCuen-Wurst C, Ruggieri M, Allison КС. Disordered eating and obesity: associations between binge-eating disorder, night-eating syndrome, and weight-related comorbidities. Ann N YAcad Sci 2018; 1411 (1): 96-105.
6. Park HJ, Lee SE, Kim HB, et al. Association of obesity with serum leptin, adiponectin, and serotonin and gut microflora in beagle dogs. J Vet Intern Med 2015; 29 (1): 43-50.
7. Ojeda-Rodriguez A, Morell-Azanza L, Azcona-Sanjulian MC, et al. Reduced serotonin levels after a lifestyle intervention in obese children: association with glucose and anthropometric measurements. Disminucion de los niveles de serotoninatrasunaintervencion de estilo de vidaenninosobesos: asociacion con glucosa у medidasantropometricas. Nutr Hosp 2018; 35 (2): 279-85.
8. Johnson PM, Kenny PJ. Dopamine D2 receptors in addiction-like reward dysfunction and compulsive eating in obese rats. Nat Neurosci 2010; 13 (5): 635-41.
9. Beeler JA, Faust RP, Turkson S, et al. Low Dopamine D2 Receptor Increases Vulnerability to Obesity Via Reduced Physical Activity, Not Increased Appetitive Motivation. Biol Psychiatry 2016; 79 (11): 887-97.
10. Crane JD, Palanivel R, Mottillo EP, et al. Inhibiting peripheral serotonin synthesis reduces obesity and metabolic dysfunction by promoting brown adipose tissue thermogenesis. Nat Med 2015; 21 (2): 166-72.
11. Watanabe H, Nakano T, Saito R, et al. Serotonin Improves High Fat Diet Induced Obesity in Mice. PLoS One. URL: pone. 0147143 (14 Jan 2016).
12. Ailanen L, Ruohonen ST, Vahatalo LH, et al. The metabolic syndrome in mice overexpressing neuropeptide Y in noradrenergic neurons. J Endocrinol 2017; 234 (1): 57-72.
13. Kim YJ, Bi S. Knockdown of neuropeptide Y in the dorsomedial hypothalamus reverses high-fat diet-induced obesity and impaired glucose tolerance in rats. Am J Physiol Regul Integr Comp Physiol 2016; 310 (2): 134-42.
14. Listopadova AP, Petrenko YuV Neuropeptide Y: physiological role and clinical significance. Medicine: theory and practice 2018; (3): 157-62.
15. Dodonova SA, Belykh АЕ, Bobyntsev II. Regulatory Peptides of the Melanocortin Family: Biosynthesis, Reception, Biological Effects. Kursk scientific and practical bulletin "Man and his health" 2018; (1): 99-108.
16. Osipova AA. The role of leptin in the regulation of energy metabolism and the functioning of living organisms. Environment and Energy 2019; (2): 55-82.
17. Vehapoglu A, Turkmen S, Terzioglu S. Alpha-Melanocyte-Stimulating Hormone and Agouti-Related Protein: Do They Play a Role in Appetite Regulation in Childhood Obesity? J Clin Res Pediatr Endocrinol 2016; 8 (1): 40-7.
18. Roseberry AG, Stuhrman K, Dunigan Al. Regulation of the mesocorticolimbic and mesostriatal dopamine systems by a-melanocyte stimulating hormone and agouti-related protein. Neurosci Biobehav Rev 2015; (56): 15-25.
19. Ikeda H, Ardianto C, Yonemochi N, et al. Inhibition of opioid systems in the hypothalamus as well as the mesolimbic area suppresses feeding behavior of mice. Neuroscience 2015; (311): 9-21.
20. Valbrun LP, Zvonarev V The Opioid System and Food Intake: Use of Opiate Antagonists in Treatment of Binge Eating Disorder and Abnormal Eating Behavior. J Clin Med Res. 2020; 12 (2): 41-63.
21. Gmoshinskiy IV, Apryatin SA, Shipelin VA, et al. Neuromediators and neuropeptides: the biomarkers for metabolic disturbances in obesity. Problems of Endocrinology 2018; 64 (4): 258-69.
22. Gruden G, Barutta F, Kunos G, et al. Role of the endocannabinoid system in diabetes and diabetic complications. Br J Pharmacol 2016; 173 (7): 1116-27.
23. ZinkAN, Bunney PE, HolmAA, etal. Neuromodulation of orexin neurons reduces diet-induced adiposity. Int J Obes (Lond) 2018; 42 (4): 737-45.
24. Gilon P. Cocaine- and amphetamine-regulated transcript: a novel regulator of energy homeostasis expressed in a subpopulation of pancreatic islet cells. Diabetologia 2016; 59 (9): 1855-9.
25. Munoz-Rodriguez JR, Agarrado A, Martin-Fernandez J, et al. Cocaine and amphetamine regulated transcript and brain-derived neurotrophic factor in morbid obesity. One-year follow-up after gastric bypass. Surg Obes Relat Dis 2018; 14 (11): 1732-9.
26. Aloe L, Rocco ML, Bianchi P, et al. Nerve growth factor: from the early discoveries to the potential clinical use. J Transl Med 2012; (10): 239-52.
27. Sun Q, Tang DD, Yin EG, et al. Diagnostic Significance of Serum Levels of Nerve Growth Factor and Brain Derived Neurotrophic Factor in Diabetic Peripheral Neuropathy. Med Sci Monit 2018; (24): 5943-50.
28. Mantelli F, Lambiase A, Colafrancesco V, et al. NGF and VEGF effects on retinal ganglion cell fate: new evidence from an animal model of diabetes. Eur J Ophthalmol 2014; 24 (2): 247-53.
29. Lotosh NG, Savel'eva EK, Selishcheva AA, et al. Autoantibodiesto neuron-specific proteins S100, GFAP, MBPand NGF in the serum of rats with streptozotocin- induced diabetes. Bull Exp Biol Med 2013; 155 (1): 48-51.
30. Hou Y, Linpei J, Zhang Y, et al. Activation of the NGF/TrkA signaling pathway attenuates diabetic erectile dysfunction. Oncotarget 2017; 8 (62): 105692-702.
31. Uenoyama Y, Inoue N, Nakamura S, et al. Central mechanism controlling pubertal onset in mammals: A triggering role of kisspeptin. Front. Endocrinol. (Lausanne) 2019; (10): 312.
32. Quennell JH, Howell CS, Roa J, et al. Leptin deficiency and diet-induced obesity reduce hypothalamic kisspeptin expression in mice. Endocrinology 2011; 152 (4): 1541-50.
33. Song W-J, Mondal P, Wolfe A, et al. Glucagon regulates hepatic kisspeptin to impair insulin secretion. Cell Metab 2014; 19 (4): 667-81.
34. Zagoskin PP, Zagoskina IP, Savel'eva NA, et al. Modern Approaches to the Problem of Body Weight Regulation. Modern technologies in medicine 2014; 6 (3): 104-17.
35. Acar S, Paketci A, Kume Т, et al. Positive correlation of galanin with insulin resistance and triglyceride levels in obese children. Turk J Med Sci 2018; 48 (3): 560-8.
36. Duan DM, Jhang JY, WuS.etal. Modification effect of sex and obesity on the correlation of LEP polymorphisms with leptin levels in Taiwanese obese women. Mol Genet Genomic Med. URL: Jan 2020).
37. Baldini G, Phelan KD. The melanocortin pathway and control of appetite-progress and therapeutic implications. J Endocrinol 2019; 241 (1): 1-33.
38. Chumakova GA, Ott AV, Veselovskaya NG, et al. Pathogenetic mechanisms of leptin resistance. Russian Journal of Cardiology 2015; 4 (120):107-10.
39. Lv Y, Liang Т, Wang G, et al. Ghrelin, a gastrointestinal hormone, regulates energy balance and lipid metabolism. Biosci Rep. URL: (25Sep2018).
40. Nesic DM, Stevanovic DM, Stankovic SD, et al. Age-dependent modulation of central ghrelin effects on food intake and lipid metabolism in rats. Eur J Pharmacol 2013; (710): 85-91.
41. Achari AE, Jain SK. Adiponectin, a Therapeutic Target for Obesity, Diabetes, and Endothelial Dysfunction. Int J Mol Sci 2017; 18(6): 1321.
42. Al-Hamodi Z, Al-Habori M, Al-Meeri A, et al. Assosiation of adipokines, leptin/adiponectin ratio and C-reactive protein with obesity and tipe 2 diabetes mellitus. Diabet Metabol Syndrome 2014; 6(1): 99.
43. Parfenova NS, Tanyansky DA. Adiponectin: effects on metabolic and cardiovascular disorders. Arterial Hypertension 2013, 19(1): 84-96.
44. Finan B' et al. Reappraisal of GIP Pharmacology for Metabolic Diseases. Trends Mol Med 2016; (22): 359-76.
45. Gupta P, Bala M, Gupta S, et al. Efficacy and risk profile of anti-diabetic therapies: Conventional vs traditional drugs-A mechanistic revisit to understand their mode of action. Pharmacol Res 2016; (113): 636-74.
46. Volkov VP New pancreatic hormones: amylin (literature review). Universum: medicine and pharmacology, 2014; 11 (12): 1.
47. Bolotova NV, Raigorodskaya NYu, Averyanov АР, et al. Specificities of neuroendocrine-immune status in obese adolescent boys. Vopr. det. dietol. (Pediatric Nutrition). 2020; 18 (2): 15-22.
48. Yanik Т, Dominguez G, Kuhar MJ, et al. The Leu34Phe ProCART mutation leads to cocaine- and amphetamine-regulated transcript (CART) deficiency: a possible cause for obesity in humans. Endocrinology 2006; 147 (1): 39-43.
49. Rubino F, Gagner M, Gentileschi P, et al. The early effect of Roux-en-Y gastric bypass on hormones is involved in body weight regulation and glucose metabolism. AnnSurg 2004; (240): 236-42.

2020_03_707-713.pdf363.17 KB

No votes yet