Saratov JOURNAL of Medical and Scientific Research

Distinctive features of morphological changes in renal tissue with different models of light desynchronosis

Year: 2019, volume 15 Issue: №3 Pages: 697-700
Heading: Рathophysiology Article type: Original article
Authors: Zlobina O.V., Ivanov A.N., Milashevskaya T.V., Bugaeva I.O.
Organization: Saratov State Medical University

Purpose: a comparative analysis of the morphological changes of the kidneys that occur with different models of light desynchronization. Material and Methods. The study was conducted in two stages on 60 white male rats. Model LL 0:24 was studied on the first and second experimental groups, which were in conditions of round-the-clock light exposure for 10 and 21 days. Model LD 18: 6 was studied in the third and fourth experimental groups, which were also in the experimental conditions for 10 and 21 days, respectively. The control group throughout the experiment was in vivo. Results. The recorded decrease in the size of the renal corpus in animals of the third and fourth groups is more persistent and pronounced compared with changes in the first group. The reduction in the area of the vascular glomeru-lus and the expansion of the Shumlyansky — Bowman capsule with round-the-clock illumination are observed only for 21 days, and when studying the 18:6 model, these figures are significantly different from the control values already on the 10th day of the experiment. Also, animals of the third experimental group recorded significant changes in thejuxta-medullary nephrons, which is associated with the activation of collateral blood flow on the 10th day of the experiment. Conclusion. The detected morphological changes indicate a stronger stress effect of the LD 18:6 model, compared with the LL 0:24 model. However, in both experimental groups, the observed changes are ischemic in nature, leading to the development of sclerotic changes, which can adversely affect the work of the kidneys and lead to the development of irreversible changes.

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