Saratov JOURNAL of Medical and Scientific Research

Clinical and etiological and hemostasiological features of isolated optic disk vasculitis

Year: 2019, volume 15 Issue: №2 Pages: 465-469
Heading: Ophtalmology Article type: Original article
Authors: Emanova L.P., Egorov V.V., Smoliakova G.P., Danilova L.P., Povalyaeva D.A., Zhajvoronok N.S.
Organization: Postgraduate Institute for Public Health Workers, The Khabarovsk branch of the S. Fedorov Eye Microsurgery Federal State Institution
Summary:

 Purpose: the study clinical, etiological and intravascular hemostasiological features of isolated optic disk vasculitis (IODV). Material and Methods. 27 patients with IODV. Duration of the disease at the time of initial appeal ranged from 5–7 days to 12 weeks. The criterion for inclusion in the study was the absence in patients systemic vasculitis, severe cardio and cerebrovascular diseases and systemic immunopathological diseases. One of the main places in the study was devoted to laboratory diagnosticmethods — enzyme-linked immunosorbent assay using set of reagents (test system «Bioservice», Russia) for detection of specifc antibodies to various infections in blood serum. The average period of study patients was 12 months. Results. The exudative type of infammation (67 %), moderate hemorrhagic activity and high risk of macular lesions are typical for IODV; in etiological structure of IODV prevail herpes viral infection and foci of chronic bacterial infections. High average infectious index (2.0±0.1) indicates predominance of mixed infections in patients. The results of laboratory studies have established that pathogenetic mechanisms of development of IODV are associated with activation of the vascular-platelet and coagulation hemostasis and depression of fbrinolysis. Conclusion. Close relationship established between changes in intravascular hemostasis and the clinical activity of disease, which necessitates inclusion in program of complex treatment patients with IODV, along with basic corticosteroid therapy and sanitation of infection foci, medications that normalize hemostasis.

Bibliography:
1 Egorov VV, Smoliakova GP, Luzyanina VV, Solovyova YuB. Visual Pathway Disorder. Khabarovsk, 2007; 135 p.
2 Ermakova NA. Classifcation and clinical evaluation of uveitis. RMJ: Clinical Ophthalmology 2003; (4): 146–9
3 Ustinova EI. Endogenousuveitis. Selected lectures for ophthalmologists. St. Petersburg, 2017; 204 p.
4 Ermakova NA. Clinic, etiopathogenesis and treatment of retinal vasculitis: DSc abstract. Moscow, 2004; 48 p.
5 Moshetova LK, Nesterov AP, Egorov EA, eds. Ophthalmology: Clinical recommendations. Moscow, 2006; 332 p.
6 Emanova LP, Smoliakova GP, Egorov VV, et al. Modern possibilities of pathogenetic treatment of neurovasculitis. Modern technologies in ophthalmology 2018; (2): 186–8
7 Ermakova NA. Comparative evaluation of efectiveness of corticosteroids and cytotoxic drugs in treatment of retinal vasculitis in Behcet»s disease. The Russian Annals of Ophthalmology 2002; 118 (5): 33–5
8 Povalyaeva DA, Egorov VV, Smoliakova GP, et al. Clinical and immunological aspects in etiological diagnosis of idiopathic optic neuritis. Modern technologies in ophthalmology 2018; (2): 232–6
9 Ermakova NA. Features of distribution of antigens of main histocompatibility system in retinal vasculitis in patients with Behcet»s disease. The Russian Annals of Ophthalmology 2003; 119 (1): 31–3
10 Barkagan ZS, Momot AP. Basis of diagnosis of hemostatic disorders. Moscow, 1999; 224 p.
11 Abu El-Asrar AM, Herbort CP, Tabbara KF. Diferential diagnosis of retinal vasculitis. Middle East Afr J Ophthalmol 2009; 16 (4): 202–18.

AttachmentSize
2019_02-1_465-469_1.pdf297.13 KB

No votes yet