№1, 2019, volume 15

The goal of this study was to perform a multivariable analysis of immunobiochemical parameters which reflect the state of nervous system microstructure in Parkinson's disease (PD). Materials and Methods. The study included 54 patients of the main group with a diagnosis of PD and 6 patients of the control group. The immunoreactivity profiles of natural regulatory auto-AB in serum were determined by ELISA using the ELI-P-Complex assay. The following parameters were assessed: ABto NF-200, GFAP, S100 proteins, MBP, beta-endorphin, voltage dependent Ca2+channel, H-cholinergic receptors, glutamate, dopamine, serotonin, opiate, GABA receptors. Results. The study revealed significant abnormalities in auto-AB profiles of the examined patients. Conclusion. The findings on the difference in range of auto- AB dependent on the duration of the disease and the revealed associations with the main characteristics of the disease can be used both for early diagnosis and for predicting the course of PD in the future.

The article is devoted to the scientific and practical contribution of the staff of the clinic of skin and venereal diseases of the Saratov Medical Institute in the study of etiology, pathogenesisand development of modern methods of diagnosis and treatment of rare and chronic skin diseases in the first half of the twentieth century.

The article presents a brief overview of the tuberculosis service's activities, of epidemiological situation in the Saratov region during the Great Patriotic war, and of contribution of advanced tuberculosis evacuation hospitals in reducing the number of tuberculosis cases among military personnel and civilian population in the Saratov region.

Department of Microbiology, Virology and Immunology is one of the oldest departments of Saratov State Medical University n.a. V. I. Razumovsky. It has the rich historical experience in the organizing of studies and professional activities of students, which is an integral part in training and education of a modern doctor.

The article is devoted to the 75th birth anniversary of Vitaliy Viktorovich Morrison, Professor and Merited Worker of Higher Education of the Russian Federation. Keywords: V.V. Morrison, anniversary.

The article presents the author's methods of applying business games and working in small groups in the class on the discipline Nursing. The use of active forms of education will help increase the effectiveness of the educational process.

Purpose: analysis of the level of competence formation on the basis of the results of intermediate certification of students at the Department of General Hygiene of Voronezh Medical University. Material and Methods. The article describes the dynamics of the results of intermediate certification of students enrolled in the Department of General Hygiene of Voronezh Medical University, in connection with the implementation of the competence approach. Results. A conclusion about stable results of examinations of students of all faculties for the last years is made. The highest proportion of excellent and good grades was noted among students of the medical faculty. The share of excellent marks received by students of the medical faculty was 17.4-20.7%, by students of the pediatric and medical preventive faculties — 9.6-17.8 and 1.9-17.1%, respectively. The proportion of satisfactory marks among students of the medical faculty — 31.2-37.2%. Most of all the proportion of satisfactory assessments among students of the medical preventive faculty — 51.2-69.7%. The directions of activity of the teaching staff of the department have been proposed, they will allow to increase the level of development of competencies, especially professional ones. These include the widespread use of innovative educational technologies, such as problem- oriented and design-organized learning technologies. Examples of new approaches to teaching in a

The review is devoted to antibiotic prophylaxis of infectious complications in burns. Severe burn injury often results in death. Infectious complications are the most common cause of mortality in these patients. Systemic antibiotic prophylaxis is actively used in practical medicine, but is not recommended by national and international clinical guidelines for the treatment of patients affected by burns. The principles of such prevention have not been developed yet. The data of studies of systemic antibiotic prophylaxis are inconsistent. A number of studies confirm the rationality of use of systemic antibiotic prophylaxis in persons on artificial ventilation with severe burns. This approach has been reported to reduce mortality and incidences of pneumonia significantly. There are evidences of perioperative antibiotic prophylaxis effectiveness in some surgical procedures associated with burn injury. Studies also demonstrate antibiotic prophylaxis and intestine decontamination combination effectiveness in preventing from complications in burn patients. Besides antibiotic prophylaxis, other pharmacological approaches currently are being developed in order to reduce the incidence of infectious complications in burns. Preclinical studies have shown the effectiveness of statins and topical probiotics in the prevention of burn sepsis in the experiment. The development and implication of early diagnostic methods for infectious complications is one another possible way to prevent severe infections in patients with burn injury.

Restoration and regeneration of tissues are complex processes involving a large number of signaling mechanisms. In this study possible mechanisms of angiogenesis during tissue regeneration are presented. One of these mechanisms is the creation of a new capillary layer by angiogenesis. Previously it was believed that high and rapid levels of capillary growth are necessary for optimal healing of tissues. But several studies have demonstrated that a period of vascular regression occurs after the growth of blood vessels in a wound, and the number of the newly formed vessels decreases until the number of the blood vessels is equal to the density of the vascular network in the intact tissue. Reduced inflammation and angiogenesis are features of optimal healing.

Objective: comparative evaluation of skin microcirculatory functional changes over the implantation area of polycap-rolactone scaffolds with mineral carriers: vaterite and hydroxyapatite. Material and Methods. The experimental study was performed on 43 rats divided into three groups: two test groups and one negative control group. Polycaprolactone PCL-scaffolds containing ovalbumine and of no biocompatibility were implanted into the rats of negative control group (n=15). The implantation of PCL- scaffolds containing vaterite under their skin was performed on rats of the first test group, and animals of the second test group were implanted with PCL-scaffolds containing hydroxyapatite. The method of laser Doppler flowmetry was used to study the microcirculatory flow. Results. The constant increase in the perfusion index has been observed in the area of non-biocompatibile scaffolds implantation. Thechanges in local skin blood flow modulation have been also detected. The transient character of local microcirculatory responses with total normalization of skin perfusion and its mechanisms has been noticed by the 21st day of the trial following PCL-scaffolds with vaterite and hydroxyapatite implantation. Conclusion. The dynamic monitoring has allowed finding that mineralization of PCL-scaffolds with vaterite as well as hydroxyapatite leads to no prominent changes in skin perfusion at subcutaneous implantation tests on white rats suggesting the biocompatibility of these scaffold types.