Saratov JOURNAL of Medical and Scientific Research

Radiation methods for evaluating renal function in children

Year: 2018, volume 14 Issue: №3 Pages: 385-388
Heading: Radiology Article type: Review
Authors: Chekhonatskaya M.L., Averianov А.Р., Uts I.A., Velikanova M.G., Bobylev D.A., Chekhonatsky I.A.
Organization: Clinical hospital n.a. S. R. Mirotvortsev SSMU, Russian Medical Academy of Postgraduate Education, Moscow, Saratov State Medical University

 An accurate assessment of renal function is critical for adequate dosing of medications. The most informative marker reflecting the functional state of the kidneys is glomerular filtration rate (GFR). Determination of inulin clearance is the most accurate way to assess GFR in children and adults. In this case, the method is invasive, cumbersome, younger children require the installation of a urinary catheter. Techniques for radioisotope estimation of GFR can solve this problem, but all widely used radioisotopes have the ability to bind slightly to plasma proteins, which leads to an underestimation of real values.

1. Filler GM. The challenges of assessing acute kidney injury in infants. Kidney Int 2011; 80: 567-8
2. Pedersen M, Karstoft K, Lodrup A, et al. Advantages and controversies in the era of intrarenal volumetry. Am J Nephrol 2011; 33 (SuppM): 40-45
3. Cataldi L, Mussap M, Bertelli L, et al. Cystatin С in healthy women at term pregnancy and in their infant newborns: relationship between maternal and neonatal serum levels and reference values. Am J Perinatal 1999; 16: 287-95
4. BokenkampA, Herget-Rosenthal S, Bokenkamp R. Cystatin C, kidney function and cardiovascular disease. Pediatr Nephrol 2006; 21: 1223-30
5. Beck M, Graf C, Ellenrieder B, et al. Long-term outcome of kidney function after twin-twin transfusion syndrome treated by intrauterine laser coagulation. Pediatr Nephrol 2005; 20:1657-9
6. Kort SA, Bouman AA, Blankenstein MA, et al. Cystatin С can be measured reliably in capillary blood samples. Clin Chem 2005; 51: 903-4
7. Bokenkamp A. Kidney function itself, and not cystatin C, is correlated with height and weight. Kidney Int 2005; 67: 777-8, author reply 778-9
8. Filler G, Browne R, Seikaly MG. Glomerular filtration rate as a putative 'surrogate end-point' for renal transplant clinical trials in children. Pediatr Transplant 2003; 7: 18-24
9. Filler G, Huang SH, Yasin A. The usefulness of cystatin С and related formulae in pediatrics. Clin Chem Lab Med 2012; 50 (12): 2081-91
10. Poge U, Gerhardt T, BokenkampA, et al. Time course of low molecular weight proteins in the early kidney transplantation period — influence of corticosteroids. Nephrol Dial Transplant 2004; 19: 2858-63
11. Bokenkamp A, van Wijk JA, Lentze MJ, et al. Effect of corticosteroid therapy on serum cystatin С and beta2-microglobulin concentrations. Clin Chem 2002; 48: 1123-6.
12. BokenkampA, Herget-Rosenthal S. Urinary cystatin С as a marker of GFR? A word of caution. Pediatr Nephrol 2004; 19: 1429
13. BokenkampA, Ozden N, Dieterich C, et al. Cystatin С and creatinine after successful kidney transplantation in children. Clin Nephrol 1999; 52: 371-6.
14. Bokenkamp A, Domanetzki M, Zinck R, et al. Cystatin С — a new marker of glomerular filtration rate in children independent of age and height. Pediatrics 1998; 101: 875-81
15. Filler G, Sharma AP How to monitor renal function in pediatric solid organ transplant recipients. Pediatr Transplant 2008; 12:393-401
16. Odlind B, Hallgren R, Sohtell M, etal. Is 1251 iothalamate an ideal marker for glomerular filtration? Kidney Int 1985; 27: 9-16
17. Bertholet-Thomas A, Ranchin B, King LA, et al. Post-diarrheal haemolytic uremic syndrome: when shall we consider it? Which follow-up? Arch Pediatr 2011; 18: 823-30
18. Rehling M, Nielsen LE, Marqversen J. Protein binding of 99Tcm-DTPA compared with other GFR tracers. Nucl Med Commun 2001; 22: 617-23
19. Rehling M, Moller ML, Thamdrup B, et al. Simultaneous measurement of renal clearance and plasma clearance of 99mTc-labelled diethylenetriaminepenta-acetate, 51 Cr-labelled ethylenediaminetetra-acetate and inulin in man. Clin Sci (Lond) 1984;66:613-19
20. Peters AM. The kinetic basis of glomerular filtration rate measurement and new concepts of indexation to body size. Eur J Nucl Med Mol Imaging 2004; 31: 137-49
21. Schwartz GJ, Munoz A, Schneider MF, et al. New equations to estimate GFR in children with CKD. J Am Soc Nephrol 2009; 20: 629-37
22. Stevens LA, Levey AS. Measured GFR as a confirmatory test for estimated GFR. J Am Soc Nephrol 2009; 20: 2305-13
23. Assadi M, Eftekhari M, Hozhabrosadati M, et al. Comparison of methods for determination of glomerular filtration rate: low and high-dose Tc-99m-DTPA renography, predicted creatinine clearance method, and plasma sample method. Int Urol Nephrol 2008; 40: 1059-65
24. Russell CD, Bischoff PG, Kontzen FN, et al. Measurement of glomerular filtration rate: single injection plasma clearance method without urine collection. J Nucl Med 1985; 26: 1243-7
25. Itoh К Comparison of methods for determination of glomerular filtration rate: Tc-99m-DTPA renography, predicted creatinine clearance method and plasma sample method. Ann Nucl Med 2003; 17:561-5.
26. LaFrance ND, Drew HH, Walser M. Radioisotopic measurement of glomerular filtration rate in severe chronic renal failure. J Nucl Med 1988; 29: 1927-30.
27. Levey AS, Coresh J, Greene T, et al. Using standardized serum creatinine values in the modification of diet in renal disease study equation for estimating glomerular filtration rate. Ann Intern Med 2006; 145:247-54
28. Tofts PS, Cutajar M, Mendichovszky IA, et al. Precise measurement of renal filtration and vascular parameters using a two-compartment model for dynamic contrastenhanced MRI of the kidney gives realistic normal values. Eur Radiol 2012; 22: 1320-30
29. Michaely HJ, Metzger L, Haneder S, et al. Renal BOLD-MRI does not reflect renal function in chronic kidney disease. Kidney Int 2012; 81: 684-9
30. Favre HR, Wing AJ. Simultaneous 51Cr-edetic acid, inulin, and endogenous creatinine clearances in 20 patients with renal disease. Br Med J 1968; 1: 84-6
31. Gaspari F, Perico N, Ruggenenti P, et al. Plasma clearance of nonradioactive iohexol as a measure of glomerular filtration rate. J Am Soc Nephrol 1995; 6: 257-63
32. Medeiros FS, Sapienza MT, Prado ES, et al. Validation of plasma clearance of 51 Cr-EDTA in adult renal transplant recipients: comparison with inulin renal clearance. Transpl Int 2009; 22: 323-31
33. Hernandez Ocampo J, Torres Rosales A, Rodriguez Castellanos F. Comparison of four methods for measuring glomerular filtration rate by inulin clearance in healthy individuals and patients with renal failure. Nefrologia 2010; 30: 324-30
34. Berg UB, Back R, Celsi G, et al. Comparison of plasma clearance of iohexol and urinary clearance of inulin for measurement of GFR in children. Am J Kidney Dis 2011; 57: 55-61.

2018_3_385-388_1.pdf278.2 KB

No votes yet