№1, 2018, volume 14

The aim is to assess skin microcirculation changes arising during subcutaneous implantation of polycaprolactone scaffolds mineralized by vaterite. Material and Methods. The experiment was carried out on 30 albino rats divided into two groups: a negative control group and an experimental one. We implanted polycaprolactone scaffold with exhausted foreign protein subcutaneously into rats of the negative control group. We implanted polycaprolactone matrix mineralized by vaterite subcutaneously into the animals of the experimental group. Research methods include laser Doppler flowmetry and morphological examination of the tissues of the matrix implantation area. Results. Changes of skin microcirculation over the matrix allocation area correspond to the morphological pattern of tissue reactions. Biocompat-ibility disorders take the form of inflammation in the scaffold implantation area that is accompanied by stable perfusion rise associated with local bloodstream modulation changes. We did not observe inflammation signs in the surrounding scaffold tissues during implantation of polycaprolactone matrices mineralized by vaterite. Besides local microcircula-tory reactions possess a transient character disappearing completely by the 21st day after the implantation. Conclusion. Complex of the given functional and morphological studies allow us to ascertain high-grade biocompatibility of polycaprolactone matrices mineralized by vaterite thus giving rise to prospect of their use for tissue regeneration stimulation.

The aim: to study etiological role of opportunistic microflora in the pathogenesis of implant-associated inflammation in patients after primary knee joint replacement and antibiotic sensitivity of main agent groups. Material and Methods. The retrospective analysis of microbiological samples of 383 patients with implant-associated inflammation occurred after primary total knee replacement. Results. Gram-positive cocci (63.5%) are the leading agents of implant-associ- ated inflammation, and there is an increase in the etiological role of coagulase-positive Staphylococci. Main agents of Gram-negative group were Enterobacteraceae and non-enzyme bacteria. We revealed high resistance of Staphylo-coccus spp. to antibiotics of various groups. Oxazolidinones and glycylcyclines were the most active among all antibiotic groups. Gram-negative bacteria were highly resistant to cephalosporine and macrolides with carbapenems and fluoroquinolones being most active. Conclusion. Gram-negative Enterobacteraceae, non-enzyme bacteria and Gram-positive cocci are most significant etiological factors in the pathogenesis of implant-associated inflammation in patients after primary total knee replacement.

Purpose: to generalize and systematize the information available in the literature about the anatomy of the posterior connective arteries in adults. Scientific works (monographs, articles, dissertations and abstracts of dissertations) of native and foreign authors for the period from 1928 to 2017 were worked out to achieve the goal. Data on the variants of artery discharge, areas of blood supply and major anomalies are presented. The size characteristics of arteries (length, outer diameter, wall thickness and lumen diameter) are presented taking into account bilateral, age and sexual differences.

The aim: development of conceptual provisions aimed at updating and ubiquitous introduction of a preventive system of dental care for students in higher and secondary vocational schools. Material and Methods. The authors rely on data from comprehensive surveys conducted in Moscow, in the Stavropol Territory, in Volgograd, in the city of Pyatigorsk. Results. It is established that the main diseases of students are dental caries and periodontal diseases (most often in the initial form). There is a trend of loss of dental health of students from 1 to 4 courses. Loss of health (even for objective reasons) is destructive for the economy and society. Solution of this problem will ensure the provision of systemic prevention and enhance the dental activity of the contingent of students. An estimation of the required investments related to the opening and operation of dental offices at higher and secondary professional educational institutions was made. Conclusion. The possibilities of social investment of the dental service of educational institutions with the use of mechanisms of fundraising are shown. Strengthening the dental services of educational institutions will help to improve the dental health of the student population. Social investment of educational institutions has many attractive features for the population and business entities.

The aim: to study the dynamics of the incidence of skin melanoma among various population groups of the multi-million territory. Material and Methods. Primary accounting records for 21 years (1995-2016) on the newly diagnosed disease, annual reports of the Samara Regional Clinical Oncology Center, annual statistical reports of the established form (Form 7 and Form 35). The following statistical methods were used: extrapolation method, linear and polynomial regression model. Results. The results indicate an increase in the incidence of skin melanoma among older people. Conclusions are drawn about the need to organize screening examinations among groups with a high incidence of skin melanoma.

Aim: to study the effectiveness of the implementation of the telemedicine program for the prevention of cardiovascular diseases in patients from high risk group and patients with arterial hypertension. Material and Methods. On the basis of "Railway clinical hospital at Saratov-ll station of "Russian Railways" developed and introduced to the work of the telemedicine program for the prevention of cardiovascular diseases in patients from high risk group that integrates all the activities of rehabilitation institutions and nursing nursing and telemedicine center. The analysis of efficiency of telemedical prevention work in the group of persons with risk factors and patients with arterial hypertension was performed. Results. In the group of patients participating in the telemedicine program, a decrease of morbidity with temporary disability on average by 58.8%; not registered any case of transfer of disease in the subsequent stage; there was a decline in hospitalization rates about of hypertension is 17.4%, and a reduction in the level of removal from flight among workers in locomotive service because of high blood pressure and excessive heart rate from 7.9 to 3.6 cases per 10000 examinations. Conclusion. Implementation of "home" telemedicine monitoring of blood pressure, heart rate, pulse rate, regularity of taking medications, virtual communication between doctor and patient, a visit to the online "Schools patient for the prevention of cardiovascular diseases" demonstrated sufficient efficacy. Tele-health program for the prevention of cardiovascular disease in patients from high risk group and patients with arterial hypertension help to teach patients to correct risk factors and to control their disease.

The aim of the work is associated with investigation of realization of knowledge of statistics and evidence-based medicine in activities of health care supervisors. Material and Methods. There were used sociological, statistical and analytical methods of investigation. There has been carried out an anonymous questioning of 92 physicians-organizers during the process of their advanced training in the specialty "Health care organization and public health". Results. It has been established that in their practical work health care supervisors do not completely realize possibilities of both medical statistics and evidence-based medicine which is closely connected with medical statistics. The complex of reasons has been determined according to the situation. Health care organizers have been revealed to have low levels of knowledge of medical statistics (2,60±0,03 marks) and evidence-based medicine (2,32±0,03 marks). It has been demonstrated that during the course of advanced training in the specialty "Health care organization and public health" these levels and motivation of students may be significantly raised (3,79±0,05 and 4,13±0,06 marks). Conclusion. The obtained results of the investigation are recommended to be used both in practical activities of health care supervisors and in the process of their professional training.