№3, 2016, volume 12

The article presents the biography of Professor J. J. Plenck and his scientific and practical contribution to the development of European clinical medicine in the second half of the 18th century and in the establishment of world scientific dermatology.

Often while treating psoriasis, clinicians face great difficulty in choosing the best treatment for patient and often face the question such as: what preparation is more suitable in a concrete case? Especially in psoriasis associated with comorbid diseases. In this article the data from Russian and foreign literature is collected about the effectiveness of methotrexate (in small and medium doses) in treating not only psoriasis but also other comorbid diseases. The positive effects of this medication from cytostatic group having not only anti-tumor activity but also immunosuppressive effect are evident not only on underlying disease, but also on the associated disease that has similar pathogenesis.

The aim of the proposed study is to demonstrate the benefits of using specialized cosmetic products as part of basic skin care for children with Atopic Dermatitis (AD). The epidermal barrier dysfunction is known to be the leading factor in pathogenesis of atopic dermatitis and it manifests as dry skin, imbalance in the composition of lipids of the stratum corneum and water-lipid mantle and alterations in the activity of proteases. Due to xerosis, the skin gets easily affected by allergens, irritants and pathogenic microorganisms, which triggers the "itch-scratch" cycle and can lead to AD exacerbation and significantly deteriorate the quality of life of the patient. The basic skin care using the moisturizing and soothing cosmetic products (emollients) is acknowledged by all major Guidelines for treatment of AD as an important part of therapy. Significant improvements in skin status as well as the child's well-being can be achieved with use of this simple to understand skin care algorithm that includes proper skin cleansing, moisturizing and itch prevention.

This review summarizes the literature, reflecting the use of curcumin in historic aspect, its physical and chemical properties, and also results of different researches to demonstrate the effectiveness of diferoylmethane in treatment of various diseases, particularly in treatment of skin diseases.

Localized scleroderma (LS) is a disease that is characterized by the appearance of inflammatory, sclerotic and/or atrophic changes in the affected areas of the skin and underlying tissues. In ICD-10, the disease is considered under category L94 "Other localized connective tissue changes". This paper presents the classification of the disease developed for federal guideline 2015, for management of patients with localized scleroderma. Also, a brief description of the various methods of diagnosis of the disease, including laboratory tests, instrumental methods and disease severity scale are presented.
Keywords: scleroderma, diagnostics, dermatology.

Aims: analysis of dynamics and pattern of syphilis incidence in 2011-2015 years in Saratov region. Materials and methods. The article provides analysis of the state statistical supervision forms from 2011-2015. Results. The analysis of the data obtained from the state statistical supervision forms during 2011-2015 years has shown the decreasing tendency of syphilis incidence. However, an unfavorable situation still remains in number of territories of Saratov region. The indicators of morbidity caused by late syphilis and neurosyphilis have increased. Conclusion. High incidence of syphilis has negative effect on the reproductive health of the general population. The fast spread of disease is generating special interest in conditions of demographic crisis.

Aim: to study the clinical polymorphism of psoriasis widely in Saratov region for the last 30 years period. Materials and methods. A retrospective analysis of medical records of 2083 patients with various forms of psoriasis, which were hospitalized at the Clinic of Skin and Venereal Diseases of Saratov Medical Institute in the period from 1984 to 1988 and data for statistical comparison from register of 1450 medical records of patients with various forms of psoriasis, also hospitalized at the Clinic of Skin and Venereal Diseases of Saratov State Medical University in the period of 2009-2013. Results. An increase in the incidence of severe and atypical forms of dermatosis is noted. Exudative and pustular forms of psoriasis are found more commonly. Psoriatic arthritis is noted to be slightly more associated with exudative form. Conclusion. The risk of psoriasis developing is noted in the age group of 10-30 years. In psoriatic arthritis an increase in morbidity is noted in the period of 30-60 years.

The aim of the work was to create optimized composite structures on the basis of nanoscale aggregates of fla-vonoids and study of their antimicrobial and regenerative properties. Material and methods. Antimicrobial activity of the resulting preparation was studied using the serial dilution method. Standard and clinical strains of Gram-positive and Gram-negative bacteria and microscopic fungi were used as experimental models. Assessment of regenerative effect of structures containing nanoaggregates flavonoids on experimental models of full thickness skin wounds was performed. Results. The high antimicrobial activity of the created structures is seen against opportunistic pathogenic microorganisms including clinical isolates resistant to multiple antibiotics. Displaying the reliable increase in rate of healing of experimental full thickness skin wounds by stimulating regenerative processes. Conclusion. Developed preparation containing "core — shell" structure stabilized by polyelectrolyte based flavonoid nanoaggregates can be considered as a potentially new type of drugs for use in cosmetology and dermatology as well as in the treatment of contaminated surgerical wounds and thermal injuries.

Aim: to study the features of lichen planus in the Krasnodar region. Materials and methods. Total 68 clinical cases have been analyzed. The patients were subdivided into age groups in accordance with physiological age gradation. The Classification of lichen planus proposed by the Federal clinical guidelines for the management of patients with lichen planus (Moscow, 2015) was used. The diagnosis in each case was confirmed by histological examination of biopsy specimens of the skin. The data on the prevalence of lichen planus was obtained from the annual reports of the Clinical dermatovenerology dispensary of Krasnodar city from year 2012 to 2015. Results. Women were found to suffer

Objective; to choose the optical clearing agent with the best illuminating ability in the long-wave UV spectrum used in phototherapy. Material and methods. Ex vivo skin samples were used as objects of study. Measurement of the total transmission spectra of the skin sections was carried out on a multi-channel spectrometer Ocean Optics QE 65000 (Ocean Optics, USA) using 4 optical clearing agents (40% glucose solution, glycerol, propylene glycol, oleic acid).
Results. Having conducted a comparative analysis of ex vivo data collected from spectroscopy of these optical clearing agents at a wavelength of 370 nm, it was found that the maximum optical clearing was achieved using propylene glycol at 44 minutes, which was 11.56%. Conclusion. The use of optical clearing agents is possible not only to improve the visualization of the skin structure, but also to explore the dynamics of light transmission in long-wave UV A-1 therapy of patients.