№4, 2015, volume 11

Purpose: to study biochemical indices of peripheral blood which show organs functional changes. Material and Methods. The experiments were carried out on white mice in dynamics development of pseudomonas aeruginosa caused by intraperitoneal injection of various dosage of exotoxin A. Results. The dosage-dependent disturbances in activity of transaminases, a-HBDH, in content of proteins, lipids and cholesterol were revealed. The received data have determined the hepatotoxic effect of pseudomonas aeruginosa exotoxin A on changes of biochemical blood markers of liver function. Conclusion. The expressed hepatotoxic effect of Pseudomonas aeruginosa exotoxin A has been determined during all the phases of experiment even at sublethal toxin dose.

Purpose: to determine the content of neuroamines (histamine, serotonin, catecholamines) in bioamine structures of bone marrow after autotransplantation. Material and methods. Animals were injected into the tail vein of bone marrow suspension obtained from the femur of the same mouse. It was taken from the femoral bone marrow of 1 ml and placed in 2 ml of physiological saline and thoroughly stirred. 1 ml of bone marrow suspension was injected into the tail vein. Cryostat sections were treated with luminescent-histochemical methods. Results. After bone marrow autotransplantation marked changes were observed in the neurotransmitters of the bone marrow — an increasing number of granular luminescent cells decrease in the amount of granules in them, and a decrease in the number of mast cells because of their degranulation. A weak luminescence was determined in nuclei in neutrophils. Perhaps this proves the activation of the immune response. Conclusion. The bone marrow autotransplantation leads to a redistribution of the structures of the bone marrow of histamine, catecholamines and serotonin, which changes the direction of cytodifferentiation, the content of neuroamines in granular luminescent cells and mast cells (cells of autonomic regulation).

Purpose: the analysis of anthropometric characteristics of cardiovascular continuum of patients with coronary heart disease (CHD). Materials and methods. The study of the leading anthropometric predictors in the long-term prognosis of patients with coronary artery disease is based on the results of observation of 238 patients of both sexes of working age who are undergoing treatment for coronary heart disease in hospitals of Saratov. Anthropometric parameters included in the study of respondents with coronary artery disease, were measured by the common method of V. V. Bu-nak. The received data were processed by standard methods of mathematical statistics. Results. During the research of anthropometric characteristics of respondents with CHD, male, it was found that the average length of the patient's body up to 50 years is of 175,0±1,2cm, aged 51-55 years, is 172,0±0,7cm, age 55 is 175,0±0,9cm. In the process of study it is found that the dynamics of clinical, instrumental and anthropometric indicators for the period of observation is of the predictive value. Conclusion. The analysis of anthropometric predictors, including morphological characteristics and the human body type make it possible to objectify distant prognosis of patients with coronary artery disease.

Objective: to carry out comparative analysis and identify patterns of topographic variation patterns of lumbar spine in normal and degenerative changes. Material and methods. CT- and MRT-grams for men and women I (M1-22-35 years; W — 21-35 years) and II (M2-36-60 years; W2-36-55 years) periods of mature age with no signs of trauma, scoliosis and systemic diseases of the spine (n=140) and CT- and MRT-grams in patients with revealed degenerative changes in the lumbar spine degree II-III (n=120). The pictures with digital PACS system measure the height of the vertebral body, intervertebral disc height, vertical, horizontal diameter and the area of intervertebral foramen. Results. The height of the lumbar vertebral bodies normally increased from27,90±0,38mmatthe level of L, to 29,93±0,33 mm Lm, and then decreased to 24,35±0,27 mm at level L^, in osteochondrosis it is statistically significantly lower at all levels on average by 20%. The height of the intervertebral disc with osteochondrosis below at all levels by an average of 25% of its value in the range 5,27±0,19 to 6,13±0,17mm, while the normal disc height varies from 6,88±030 to 9,36±0,28mm. The area of intervertebral holes normally ranging from 103,29±5,78 to 127,99±5,92mm2, with osteochondrosis aperture area is reduced to a greater extent by decreasing the vertical diameter in comparison with the horizontal. Conclusion. For the studied parameters characteristic topographic variability has been determined. The maximum values parameters are marked at the top of the lumbar lordosis, at chest height, lumbar and lumbosacral junctions sizes are reduced. In osteochondrosis the intervertebral disc height and the height of lumbar vertebral bodies are reduced; intervertebral foramina area is also reduced to a greater extent by reducing the vertical diameter than the horizontal one.

The actual problem recently determined is concerned with the reproductive disorders in men. Male infertility results from a variety of pathological processes in the body. It is known that most anomalies of organs of reproductive system develop in the period of prenatal ontogenesis. The review provides the data on embryogenesis of fetal testes and factors that can lead to disturbances in the formation of the testes and male infertility.

The article presents the author's analysis of the normative documents of the Russian Federation necessary for providing palliative care. According to the authors regulatory — legal support of palliative medical care to the population allows to plan and to develop this kind of assistance in Russia. To ensure the availability of palliative care it is necessary to have scientific and methodological basis and to develop a general classification of the states under which the palliative care is needed and should be organized. The procedure for medical care must be brought into conformity with the mentioned above classification. The authors consider the trends of medicalisation of palliative care in Russia in the context of dysfunctional practices of the social institute of Public Health.

Changes in the structure of public health are marked in health care round the world. Patients with chronic diseases which limit their life-important needs will live longer, suffer and as a result of these factors they will need palliative care. The article presents the author's analysis of modern interpretations of palliative care from the perspective of multi-professional and multidisciplinary approach. The article considers the main trajectory of a chronic disease, defining the modern palliative care strategy. Also the article presents the main objectives and directions of palliative care. The authors state that the adopted Russian legislative documents define palliative care as palliative medical care. The medicalisation of palliative care in Russia is considered by the authors from the perspective of the dysfunctional practices of the social institute of health.