Effect of individual and group housing of mice on the level of radioresistance
Year: 2015, volume 11 Issue: №4 Pages: 653-656
Heading: radiation medicine Article type: Original article
Authors: Dorozhkina O.V., Bulynina Т.М., Ivanov А.А..
Organization: State Scientific Research Center n.a. A.I. Burnasyan — Federal Medical Biophysical Center of Federal Medical Biological Agency
Heading: radiation medicine Article type: Original article
Authors: Dorozhkina O.V., Bulynina Т.М., Ivanov А.А..
Organization: State Scientific Research Center n.a. A.I. Burnasyan — Federal Medical Biophysical Center of Federal Medical Biological Agency
Summary:
Aim: to examine the effect of individual and group housing of mice on radioresistance. Material and methods. Effects of individual and group housing of mice on immunity and blood systems were studied on ICR (CD-1) and C57BI6 male mice before and after proton irradiation. Results. Group housing of intact animals resulted in a decline in the number of nucleated cells in the femur bone marrow and thymus mass. The irradiation with proton with energy of 171 MeV at a dose of 1 Gy causes a statistically significant greater reduction of the number of nucleated cells in the femur bone marrow in group-housed mice. A trend toward greater safety of the number of leukocytes in the peripheral blood and higher proliferative activity of bone marrow cells, as well as lower level of aberrant mitoses have been noted in individually-housed mice. Reduction processes in the recovery period of radiation sickness take place at a greater rate in group-housed mice. Conclusion. Group housing of male mice causes increased sensitivity of the blood and immunity systems to the effects of radiation and at the same time accelerates processes of radiation recovery.
Keywords: aberrant mitosis, C57BI6, ICR (CD-1), individual and group housing, mice, mitotic index, number of nucleated cells in the bone marrow, proton irradiation, spleen, thymus
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