Saratov JOURNAL of Medical and Scientific Research
Home

Morphometric parameters of air in lungs of laboratory rats on physical exercise.

Year: 2015, volume 11 Issue: №4 Pages: 645-649
Heading: Physiology and Pathophysiology Article type: Original article
Authors: Datsenko А.V., Kazmin V.I.
Organization: State Scientific Research Center n.a. A.I. Burnasyan — Federal Medical Biophysical Center of Federal Medical Biological Agency
Summary:

Aim: to determine the morphological and functional relationships between the morphometric parameters of lung airness tissue specimens of laboratory rats and indicators of physical endurance while swimming with weights and running on a treadmill. Material and methods. The physical endurance of laboratory rats evaluated in tests of swimming with weights and running on a treadmill using computer video markerless tracking. After strenuous exercise prepared histologic lung stained with hematoxylin and eosin. In morphometric study there were determined areal parameters of lung airness and pulmonary distelectasis. Results. When comparing the results of studies of physical endurance to the morphometric data of lung airness and pulmonary distelectasis identified the parameters of the same type of regression. Between changes in the morphological and physiological characteristics was a strong and average power correlation. The highest coefficient of correlation was established between the indicators of physical endurance and the parameter characterizing the degree of pulmonary distelectasis. Conclusion. Indicators of physical performance were the best in the big lung airness. At the same time, to a lesser extent than in the lung were presented wears off portions of the alveoli, the longer the biological objects to perform physical work. Fitted regression dependence characterizing the effect on physical endurance performance airiness of the lungs and spread them distelectasis.

Keywords: laboratory rats, lung airness, morphometry, physical performance, pulmonary distelectasis

Bibliography:
1. Mironov A.N., ed. Rukovodstvo po provedeniyu doklinicheskikh issledovaniy lekarstvennykh sredstv. Part 1. Moscow: Grif and K, 2012; 944 p.
2. Karkishchenko N.N., Uyba V.V., Karkishchenko V.N., Shustov E.B. Ocherki sportivnoy farmakologii. Vol. 1: Vektory ekstrapolyatsii. Moscow: Aysing, 2013; 288 p.
3. Dunnill M.S. Quantitative methods in the study of pulmonary pathology. Thorax 1962; 17 (4): 320-328
4. Hyde DM, Tyler NK, Plopper CG. Morphometry of the respiratory tract: avoiding the sampling, size, orientation, and reference traps. Toxicol Pathol 2007; 35 (1): 41-48
5. Knust J, Ochs M, Gundersen HJ, Nyengaard JR. Stereological estimates of alveolar number and size and capillary length and surface area in mice lungs. Anat Rec 2009; 292 (1): 113-122
6. Mbhlfeld C, Knudsen L, Ochs M. Stereology and morphometry of lung tissue. Methods Mol Biol 2013; 931: 367-39
7. Dawson CA, Horvath SM. Swimming in small laboratory animals. Med Sci Sports 1970; 2 (2): 51-78
8. Datsenko AV. Register indicators of physical endurance of biological objects when running a treadmill and swimming with weights using computer video markerless tracking. Saratov Journal of Medical Scientific Research 2014; 10 (4): 766-771
9. Pal'tsev M.A., Kaktursky L.V., Zayrat'yants O.V., eds. Patologicheskaya anatomiya: natsionalnoe rukovodstvo. Moscow:: GEOTAR-Media, 2011; 1264 p.
10. Datsenko A.V., Kazmin V.I. Complex microscopic express-analysis for biomedical full-scale investigation. Saratov Journal of Medical Scientific Research 2013; 9 (4): 805-808.

AttachmentSize
2015_04-01_645-649.pdf712.45 KB
All articles of the authors: Datsenko A.V. , Kazmin V.I.

No votes yet