Saratov JOURNAL of Medical and Scientific Research

Heart ischemic disease and longevity: unsolved problems

Year: 2015, volume 11 Issue: №1 Pages: 037-041
Heading: Gerontology and geriatrics Article type: Original article
Authors: Markova T.Yu., Malinova L.I., Denisova Т.Р.
Organization: Regional Hospital for War Veterans, Saratov, Saratov State Medical University
Summary:

The purpose of the study was to estimate clinical signs and course of coronary heart disease in long-livers and centenarians. Material and Methods. The study included overall population of Saratov — Engels agglomeration's long-livers (>=90 years old, n=198). Results. The rates of major clinical forms of coronary heart disease were detected: atrial fibrillation — 10.6%, chronic heart failure (with preserved ejection fraction) — 10.1 % and angina — 5.1 %. Myocardial infarction was verified in 9.6% of long-livers. Myocardial scar criteria prevailed over myocardial infarction history. Received data corroborated dissolving phenomena of coronary heart disease and noninsulin dependent diabetes mellitus in long-livers. Gender differences in electrophysiological parameters were detected in long-livers. Centenarians with the history of myocardial infarction preserved a satisfactory level of physical activity. Conclusion. Received data confirm a presence of an excessive security: prevention of coronary heart disease manifestation and progression in longevity. Long-livers should be considered as a natural model of an antiatherogenic factors and mechanisms.

Bibliography:
1. Terry DF, McCormick M, Andersen S, et al. Cardiovascular disease delay in centenarian offspring: role of heat shock proteins. Ann N YAcad Sci 2004; 1019: 502-5
2. Grimaldi MP, Candore G, Vasto S, et al. Role of the pyrin M694V (A2080G) allele in acute myocardial infarction and longevity: a study in the Sicilian population. J Leukoc Biol 2006; 79: 611-5
3. Samuel SM, Thirunavukkarasu M, Penumathsa SV, Paul D, Maulik N. Akt/FOX03a/SIRT1-mediated cardioprotection by n-tyrosol against ischemic stress in rat in vivo model of myocardial infarction: switching gears toward survival and longevity. J Agric Food Chem 2008; 56: 9692-8
4. Perls T. Genetic and environmental influences on exceptional longevity and the AGE nomogram. Ann N YAcad Sci 2002; 959: 1-13
5. Ribera-Casado JM. Ageing and the cardiovascular system. Z Gerontol Geriatr 1999; 32: 412-9. 6. Perls T, Terry D. Understanding the determinants of exceptional longevity. Ann Intern Med 2003; 139: 445-9
7. Fries JF. Aging, natural death, and the compression of morbidity. N Engl J Med 1980; 303: 130-5
8. Evert J, Lawler E, Bogan H, Perls T. Morbidity profiles of centenarians: survivors, delayers, and escapers. J Gerontol A Biol Sci Med Sci 2003; 58: 232-7
9. Smetannikova MA, Beliavskaia VA, Smetannikova NA, et al. [Functional polymorphism of p53and CCR5 genes in the long-lived of the Siberian region]. Vestn Ross Akad Med Nauk 2004: 25-8
10. Kannel WB. Office assessment of coronary candidates and risk factor insights from the Framingham study. J Hypertens Suppl 1991; 9: S13-9
11. Stohs SJ. The role of free radicals in toxicity and disease. J Basic Clin Physiol Pharmacol 1995; 6: 205-28
12. Stohs SJ, Bagchi D. Oxidative mechanisms in the toxicity of metal ions. Free Radic Biol Med 1995; 18: 321-36
13. Salonen JT, Korpela H, Nyyssonen K, et al. Lowering of body iron stores by blood letting and oxidation resistance of serum lipoproteins: a randomized cross-over trial in male smokers. J Intern Med 1995; 237: 161-8
14. Roszkowska-Gancarz M, Kurylowicz A, Polosak J, Mossakowska M, Franek E, Puzianowska-Kuznicka M. Functional polymorphisms of the leptin and leptin receptor genes are associated with longevity and with the risk of myocardial infarction and of type 2 diabetes mellitus. Endokrynologia Polska 2014; 65: 11-68 15. Emanuele E, Minoretti P, Pareja-Galeano H, San-chis-Gomar F, Garatachea N, Lucia A. Serum irisin levels, precocious myocardial infarction, and healthy exceptional longevity. Am J Med 2014; 127: 888-90
16. Nuzzo D, Vasto S, Balistreri CR, et al. Role of proin-flammatory alleles in longevity and atherosclerosis: results of studies performed on -1562C/T MMP-9 in centenarians and myocardial infarction patients from Sicily. Ann N Y Acad Sci 2006; 1089:496-501.

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