Saratov JOURNAL of Medical and Scientific Research

Clinical features of subacute course of radiation disease

Year: 2014, volume 10 Issue: №4 Pages: 858-862
Heading: radiation medicine Article type: Original article
Authors: Krasnyuk V.I., Konchalovsky M.V., Ustyugova A.A.
Organization: State Scientific Research Center n.a. A.I. Burnasyan — Federal Medical Biophysical Center of Federal Medical Biological Agency

Aim: to show the clinical features of subacute course of subacute course of radiation disease and how they differ from the typical manifestations of acute and chronic radiation syndrome. Material and methods. Materials of the Burnasyan Federal Medical and Biophysical Center Register of acute radiation disease (ARS) in the Former USSR and Russia and Materials of a Burnasyan Federal Medical and Biophysical Center database of workers "Mayak" with chronic radiation syndrome (CRS) were analyzed. There were selected 22 patients with radiation syndrome due to fractionated or prolonged accidental exposure (the main group of patients). There were formed two subgroups for comparison: patients with a typical marrowy syndrome of acute radiation disease and with chronic radiation syndrome. Statistical analysis of results was made by means of statistical software package Statistica v. 6.1 for Windows (StatSoft Inc., USA) and Microsoft Excel 2010. Results. It was found that subacute course of radiation syndrome is possible under radiation exposure with medium dose rate in the range of 0.1-0.3 Gy/day Early symptoms of the disease as a primary reaction symptoms are completely absent. First complaints appeared in the earliest one month after the start of work in adverse conditions, on the average 6 months. In the period of formation there is a pancytopenia in the peripheral blood. Duration of the formation period was also determined. In this case radiation cataracts in patients are not observed. After the termination of radiation exposure hematopoietic recovery is slow, possibly incomplete with a high probability of hemoblastosis development. Conclusions. There has been described the subacute course of radiation disease by analyzing the clinical material of patients with radiation syndrome, there has been analyzed the clinical criteria that distinguish subacute radiation syndrome from acute and chronic.

1. Guskova AK, Bajsogolov GD. Radiation disease in humans. M.: Medicina, 1971; 384 p.
2. Krasnyuk VI, Ustyugova АА. Feasibility of radiation dose range capable to cause subacute course of radiation syndrome. Saratov Journal of Medical Scientific Research 2013; 9 (4): 895-896
3. Radiacionnaya medicina: rukovodstvo dlya vrachej-issle-dovatelej i organizatorov zdravoohraneniya: Radiacionnie porazheniya cheloveka. M.: IzdAT, 2001. T. 2; 432 s.
4. Soloviev VU, Barabanova AV, Bushmanov AU, Guskova AK, llyin LA. Review of the Medical Consequences of Radiation Accidents in the Former USSR Territory (Burnasyan FMBC of FMBA of Russia Register Data). Med Radiol i Radiat Bezopasnost 2013; 58 (1): 36-42
5. BarabanovaAV, BaranovAE, Bushmanov AU, GuskovaAK. Radiatsionnie porazheniya cheloveka. Izbrannie clinicheskie lek-cii, metodicheskoe posobie. AU Bushmanov, VD Rev, eds. Moscow: Firma «Slovo», 2007; 176 p.
6. Osnovi radiatsionnoj medicini: kratkoe uchebno-metodi-cheskoe posobie. LA llyin, KV Kotenko, eds. M.: FGBU «GNC RF FMBC im. A. I. Bournasyana», 2013; 90 p.
7. Osovets SV, Azizova TV, Bannikova MV Assessment of the Impact of Dose Characteristic on the Period of Formation and Duration of Cronic Radiation Syndrome. Med. Radiol i Radiat Bezopasnost 2011; 56 (4): 17-23
8. Otchet MKZR ро tkanevim reakciyam, rannim i otdalen-nim effektam v normalnih tkanyah i organah: porogovie dozi dlya tkanevih reakcij v kontekste radiatsionnoj zaschiti / [FA Stuart at al.; red.: AV Akleev, MF Kiselev; per. s angl.: EM Zhi-dova, NS Kotova]. Chelyabinsk: Kniga, 2012; 384 p.

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