Saratov JOURNAL of Medical and Scientific Research

Studies of pathological changes in mitogenetic signal pathways in cells in cancer patients using OncoFinder software package

Year: 2013, volume 9 Issue: №4 Pages: 775-780
Heading: Genetics Article type: Original article
Authors: Korzinkin М.В., Smirnov Ph.Yu., Venkova L.S., Krupnov A.V., Kuzmina N.B., Zhestkov B.G., Ivanova E.N., Buzdin A.A., Borisov N.M.
Organization: State Scientific Research Center n.a. A.I. Burnasyan — Federal Medical Biophysical Center of Federal Medical Biological Agency, RAS Institute of Bioorganic Chemistry

Although the basic components of a plethora of mitogenic, pro- and antiapoptotic etc. signaling pathways had been thoroughly studied and summarized during a couple of past decades, the particular pattern of changes for a given cancer patient has not yet been at the focus of a special research until now. Here we suggest the possible method of
the examination of the different malignant processes influencing the intensity of pro- and anti-mitotic signaling. According to our approach, first the tumor sample (that is taken from an individual patient) is studied using mRNA microarray technique, when the expression levels (normalized by the averaged value for the same intact organ/tissue for the same population) for several thousands of genes in the malignant cells is measured. Second, these expression levels are used to calculate the summarized values of pathological changes in mitogenic signaling pathways.

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