Saratov JOURNAL of Medical and Scientific Research

Regional anesthetic activity of new decahydroquinolinyl derivative by the experimental model of terminal anesthesia

Year: 2014, volume 10 Issue: №3 Pages: 384-389
Heading: Parmacology Article type: Original article
Authors: Goncharuk V.V., Buben A.L., Vdovichenko V.P.
Organization: Grodno State Medical University

anesthesia. Material and Methods. Decahydroquinolinyl derivative under laboratory code PAS-68 synthesized in the A. B. Bekturov Institute of Chemical Sciences under the guidance of K. D. Praliev has been studied. Benzocaine, lido-caine and tetracaine were used as the comparison drugs. Male rabbits of 2,0-3,5 kg weight were used as experimental animals. A threshold of corneal sensitivity to tactile effects (Rainier index) was determined by the standard method. Computer prognosis of PAS-68 acute toxicity also was made. Results. The local anesthetic activity of 1 %, 0,5% and 0,25% solutions of PAS-68 were identified as higher than that for lidocaine and benzocaine in similar concentrations (p

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