№1, 2013, volume 9

The article gives a detailed description of contribution of professor V. V. Mikhailov into the development of pathological physiology and the department of pathological physiology of Saratov Medical University. Furthermore, it presents biographic data of professor V. V. Mikhailov reflecting his scientific work.

The article considers quality of life as an evaluation category of state of a subject in conditions of illness. The results of the research of quality of life relevant to health in patients with coronary heart disease are given in the work. Quality of life defined on the basis of the questionnaire of WHOQOL-100 supplementing an illness picture is a multiple-factor criterion in condition assessment of such category of patients.

The aim of the article is to assess the situation with the introduction of innovative forms of education into medical higher schools. The levels of introduction and techniques of modernization of medical education have been presented. Having a complex of pre-university, secondary professional, undergraduate and graduate educational programs it has been shown that the State University organization has obtained a definite approach to the work in this sphere.

The research goal is to increase efficiency of health education for subjects involved in the process of education. Materials: 498 questionnaires have been worked out for respondents. Methods: They have included supervision, questioning, free interviewing and methods for statistical processing of results of research. Results: The following factors have been revealed: peculiarity of leisure-time; bad quality of interaction between subjects of educational system and health care system. The characteristic of extra-curriculum risk factors has been done. Conclusion: It is stressed that the survey has determined the basic directions of training for teachers and adults to form healthy way of life.

Goal of the research was to study conditionality of overcoming strategies in difficult situations of social interaction by personal representations of attitude to others among medical students. Material and methods. 134 first-year students of Saratov State Medical University n.a. V. I. Razumovsky took part in the comparative diagnostic study. Results. Comparison of average indices of various strategies evidence in coping behaviour allowed revealing statistically significant dependence of coping behaviour modi in difficult situations of social interaction upon types of personal representations of attitude toward others and gender features of forming effective strategies of coping behaviour among medical students. Conclusion. Correlation between coping behaviour modi in difficult situations of social interaction and typology of personal representations of attitudes toward others among medical students was marked.

The research goal is to study probability, period of development and characteristics of a clinical course of chronic prostatitis against the background of androgen deficiency in the aging male. Materials and methods: The Aging Male Symptoms (AMS) rating scale has been applied for androgen deficiency evaluation and the International Prostate Symptom Score (IPSS) — for chronic prostatitis evaluation. 57 men with chronic prostatitis in combination with androgen deficiency in the aging male have been examined. Results: It has been concluded that the development of chronic prostatitis against the background of androgen deficiency in the aging male occurs in a shorter time period and about 1.5 times more frequently compared to androgen deficiency in the aging male at the background of chronic prostatitis. The analysis of time periods between the onset of chronic prostatitis symptoms against the background of androgen deficiency in the aging male and androgen deficiency in the aging male symptoms against the background of chronic prostatitis showed that androgen deficiency in the aging male symptoms have been revealed 1-2 years earlier than the onset of chronic prostatitis. The development of androgen deficiency in the aging male against the background of chronic prostatitis has showed a backward tendency. Signs of chronic prostatitis have been more frequently occurred in a period of four-five years earlier the androgen deficiency in the aging male development. Conclusion: The risk of development of chronic prostatitis against the background of androgen deficiency in the aging male during the next two years is actually four times higher in comparison with the development of androgen deficiency in the aging male against the background of chronic prostatitis. According to the International Prostate Symptom Score (IPSS), patients with chronic prostatitis in combination with androgen deficiency in the aging male showed higher degree of severity than patients with isolated development of chronic prostatitis.

Research objective: The study investigates the antifibrotic nephroprotective effects of aliskiren on the condition of renal hemodynamics, changes of profibrotic cytokines level and markers of renal damage in patients with nephrolithiasis undergone various types of surgery. Materials and methods: Patients have been divided into 2 groups. The investigations have been performed before the surgery and in a month period. Concentrations of TGF-p, markers of acute renal tubulointerstitial damage — NGAL and p2-microglobulin in urine, levels of ET-1 in serum and indicator of endothelial dysfunction have been determined. Assessment of renal blood flow state by Doppler ultrasonography has been carried out in the same terms. Results: As a result of aliskiren treatment the decrease of mediators of tubulointerstitial damage and nephrofibrosis, significant improvement in renal blood flow in a month period after the surgery have been marked in comparison with the group which had not received nephroprotective therapy. Conclusion: Direct renin inhibitor aliskiren may be used as a means of renal protection therapy in treatment of patients with nephrolithiasis.

Research objective: To study the role of prognostic factors in the estimation of risk development of recurrent prostate cancer after treatment by high-intensive focused ultrasound (HIUF). Objects and Research Methods: The research has included 102 patients with morphologically revealed localized prostate cancer by biopsy. They have been on treatment in Clinic of Urology of the Saratov Clinical Hospital n.a. S. R. Mirotvortsev. 102 sessions of initial operative treatment of prostate cancer by the method of HIFU have been performed. The general group of patients (n=102) has been subdivided by the method of casual distribution into two samples: group of patients with absent recurrent tumor and group of patients with the revealed recurrent tumor, by morphological research of biopsy material of residual prostate tissue after HIFU. The computer program has been used to study the signs of outcome of patients with prostate cancer. Results: Risk of development of recurrent prostate cancer has grown with the PSA level raise and its density. The index of positive biopsy columns

In Russia there are no unified approved criteria for diagnosing sepsis, and this fact complicating registration and statistical recording of its development and spread. Sepsis registration in neonatology is more difficult. The infection as a death-causing factor in full-terms newborns has been increasing for the last 10 years, even though there is the registration system, and its size is 0,51-0,60 per 1000 newborns. Early neonatal sepsis is characterized by intrauterine particularly intranatal ascending, contact or hematogenous infecting. We have analyzed the course of antenatal, intra-natal and neonatal periods in babies with congenital sepsis. To diagnose neonatal sepsis in clinical presentation of the disease three groups of criteria directly correlating with sepsis have been revealed.

Цель: на основе сопоставления показателей выявляемое™ различных нозологии «школьной» патологии у детей, начавших образование в разном возрасте, оценить состояние здоровья в течение всего 10-летнего периода обучения. Материал и методы. В исследование включены 437 детей, разделенных на группы: первую группу составили школьники, начавшие обучение в возрасте 6 лет (п=135), вторую группу — в возрасте 7 лет (п=274), третью — 8 лет (п=28). Результаты. Формирование «школьной» патологии с наибольшей частотой встречается в группе детей, которые начали обучение с 6- и 8-летнего возраста, доказан рост числа заболеваний костно-мышечной системы и органа зрения к окончанию 10-летнего образования. Заключение. Процент здоровых детей, не имеющих проявлений рассматриваемой «школьной» патологии в процессе школьного обучения, сокращается. Требуется поиск новых путей сохранности здоровья молодого поколения и создания благоприятных условий для комфортного самочувствия ребенка в школе