Saratov JOURNAL of Medical and Scientific Research

The role of vascular disorders in the genesis and maintenance of infammation in the pathogenesis of rosacea

Year: 2012, volume 8 Issue: №2 Pages: 650-654
Heading: Skin Diseases Article type:
Authors: Slesarenko N.A., Leonova M.A., Zaharova N.B., Slesarenko N.S., Reznikova M.A.
Organization: Saratov State Medical University

Aims. The study was aimed to identify relationships of immune disorders and angiogenesis in patients at different stages of rosacea. Materials and methods. We examined 110 patients with rosacea. The diagnosis was based on diagnostic criteria. We summarized the role of predictors in the development of rosacea. We investigated pro- and anti-infammatory cytokines, vascular endothelial growth actor (VEGF), fbroblast growth factor (FGF) for the detection of immune disorders and angiogenesis. Results. The immune response in patients with rosacea was of mixed Th-1 and Th-2 type which can be markers of chronic autoimmune infammation. Simultaneously with the change in cytokine profle we revealed activation of angiogenesis (high levels of VEGF, FGF).

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