Saratov JOURNAL of Medical and Scientific Research

Eclamptic coma. New algorithm of intensive therapy

Year: 2009, volume 5 Issue: №4 Pages: 541-543
Heading: Anaesthesiology and Reanimatology Article type: Original article
Authors: Yu.S. Podolskiy, I.Kh. Khapiy
Organization: Moscow Regional Scientific Research Clinical Institute n.a. M.F. Vladimirsky

The aim of this research is to increase effectiveness of treatment of patients in eclamptic coma. Current algorithm of intensive therapy corresponds to coma states methodology treatment of metabolic genesis accepted in neurological and neurosurgical practice. The main principal of intensive therapy tactics has been to restore volemic figures and perfusion-metabolic balance of brains. Decrease of mean arterial pressure (5-10% from the initial one) which defines the central perfusion pressure has been provided by magnesium sulphate and nimodipine. Stabizol has been used as plasma-substituting component to circulate in bloodstream till 36 hours. Nimodipine has provided increased cerebral
bloodflow. Proposed algorithm of intensive therapy has allowed to reduce lethality from 15.7% to 4.8%. Key words: eclamptic coma, cerebral bloodflow, cerebral perfusion pressure

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