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Morphofunctional changes in the kidneys under the influence of new cyanothioacetamide derivatives with anti-inflammatory properties

Year: 2025, volume 21 Issue: №2 Pages: 210-218
Heading: Pharmacology, clinical pharmacology Article type: Original article
Authors: Bibik E.Yu., Moiseeva I.Ya., Saul A.S., Ivanova E.R., Krivokolysko S.G., Yakubenko E.D.
Organization: Dahl Lugansk State University, Lugansk, Russia, Donetsk State Medical University, Donetsk, Russia, Penza State University, Saint Luka Lugansk State Medical University, Lugansk, Russia
Summary:

Objective: to determine morphofunctional changes in the kidneys under the influence of new derivatives of α-cyanothioacetamide with anti-inflammatory activity in a chronic experiment. Materials and methods. 80 male rats were divided into 8 individuals in 10 groups, for 10 days they received intragastric aqueous suspensions: group 1 — control (distilled water); group 2 — indomethacin at a dose of 7 mg / kg, group 3 — paracetamol at a dose of 50 mg / kg, group 4 — acetylsalicylic acid at a dose of 50 mg / kg, 5 — nimesulide at a dose of 5 mg / kg, from 6 to 10 — dihydro pyridine derivatives at a dose of 5 mg / kg. On day 11, slaughter was performed, the levels of Na+, K+, and creatinine in the blood were determined, and histological sections of the kidneys were examined. Results. The use of indomethacin, acetylsalicylic acid, and paracetamol led to impaired renal excretory function, contributing to sodium and creatinine retention in the blood. There were no statistically significant significant differences with the indicators of the intact group in the experimental groups after administration of α-cyanothioacetamide derivatives with laboratory codes d02–123, d02–139 and d02–172. These samples also did not reveal the ability to provoke the occurrence of gross structural changes in the renal parenchyma. There was no damage to the renal corpuscles with minor tubular changes. In the group receiving the compound with the d02–123 cipher, a possible potassium-sparing diuretic effect was noted. Con clusion. α-Cyanothioacetamide derivatives with codes d02–123, d02–139 and d02–172 do not contribute to impaired renal excretory function and their structural changes.

Keywords: anti-inflammatory properties, kidney, morphological features, nephrotoxicity, α-cyanothioacetamide derivatives

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All articles of the authors: Bibik E.Yu., Ivanova E.R. , Krivokolysko S.G. , Moiseeva I.Ya. , Saul A.S. , Yakubenko E.D.

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