Saratov JOURNAL of Medical and Scientific Research

Protracted herpetic keratitis in a patient with coronavirus infection (clinical case)

Year: 2021, volume 17 Issue: №4 Pages: 701-704
Heading: Ophthalmology Article type: Case report
Authors: Latypova Е.А., Zagidullina A.Sh., Mukhamadeev T.R.
Organization: Bashkir State Medical University of the Russian Health Care

Purpose: a clinical case study to analyze features of herpetic keratitis course in a patient with coronavirus infection. The presented case demonstrates the herpesvirus infection activation of the body influenced by acute coronavirus infection with damage to the cornea. It resulted in the dendritic keratitis developed for the first time in a patient's life. In the initial stage of the disease, herpetic keratitis proceeded subacutely in the course of the antiviral COVID-19 treatment, including hormones, and severely intensified after the completion of the therapy course. Clinically, herpetic keratitis was complicated by edema and infiltration of the dendritic cornea focus. New ulcerated infiltrates emerged along with the previous focal area. The cornea became vascularized, and the infection spread into its deep layers, with the anterior segment of the choroid involved in the inflammatory process. The patient's vision deteriorated to 0.02-0.01, with a protracted course of the disease. It was managed to arrest the inflammatory process in the eye with the antiherpesvirus therapy (Aciclovir orally and topically). The keratitis ended in the formation of cloudy opacities in the central cornea. The patient's vision improved to 0.5. This clinical observation indicates the need for a specific therapy for coronavirus infection complications and standard COVID-19 treatment.

1. Prevention, diagnosis and treatment of new coronavirus infection (COVID-19). Temporary guidelines. Version 8 (3 Sept 2020). Moscow, 2020; 226 p. URL: https:// static, stem/attachments/attaches/000/049/8 77/original/COVID19_recomend_v4. pdf (2 Apr 2021).
2. COVID-19 Data Repository by the Center for Systems Science and Engineering (CSSE) at Johns Hopkins University. URL: (2 Apr 2021).
3. Federal Service for Supervision of Consumer Rights Protection and Human Welfare. About confirmed cases of new coronavirus infection COVID-19 in Russia. URL: https://www/ \ a bout \ info \ news \ news (2 Apr 2021).
4. Latalska М, Mackiewicz J. The implication of ocular manifestation of COVID-19 for medical staff and patients — systematic review. Ann Agric Environ Med 2020; 27 (2): 165-70. DOI: 10.26444/aaem/122790.
5. Gupta A, Madhavan MV, Sehgal K, et al. Extrapulmonary manifestations of COVID-19. Nat Med 2020; 26 (7): 1017-32. DOI: 10.1038/S41591-020-0968-3.
6. Siedlecki J, Brand V, Schworm B, et al. Priglinger S. COVID-19: Ophthalmological Aspects of the SARS-CoV 2 Global Pandemic. Klin Monbl Augenheilkd 2020; 237 (5): 675-80. DOI: 10.1055/a-1164-9381.
7. Herpes simplex (HS) in adults. Clinical guidelines. Moscow, 2016; 55 p. URL: (2 Apr 2021).
8. Chernakova GM, Maychuk DYu, Klescheva EA, et al. Recommendations for the management of patients with herpetic keratitis/protracted keratouveitis: from problems to solutions. Ophthalmology 2019; 16 (4): 537-45.
9. Herpes against coronavirus: is there a connection, can it be a symptom of infection, treatment method. URL: (2 Apr 2021).
10. Avetisov SE. Ophthalmology. National leadership/Ed. by SE Avetisov, EA Egorov, LK Moshetova, et al. Moscow: GEOTAR-Media, 2019; 752 p. URL: https:// html (5 Apr 2021).

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