Saratov JOURNAL of Medical and Scientific Research
Home

Hemostasis test parameters in patients requiring revision knee arthroplasty

Year: 2018, volume 14 Issue: №2 Pages: 266-271
Heading: Traumatology and Orthopedics Article type: Original article
Authors: Girkalo M.V., Shakhmartova S.G., Shpinyak S.P., Mandrov A.V., Kozadaev M.N., Puchinyan D.M.
Organization:
Summary:

Objective: comparative analysis of the blood coagulation system in patients requiring revision arthroplasty of the knee joint in connection with the developed infectious and aseptic complications after total arthroplasty. Material and Methods. 37 patients with complications of total knee replacement were examined. Patients were divided into 2 groups: 1st — with signs of suppuration (n=19); 2nd — withsigns of aseptic instability of the endoprosthesis components (n=18). The control group consisted of 22 conditionally healthy people. Studied screening coagulation: activated partial thromboplastin time, prothrombin time, fbrinogen concentration, thrombin time, antithrombin III, protein C, the content of soluble fbrin-monomer complexes and D-dimers. Results. There was an increase in activated partial thromboplastin time in patients of group 2, prothrombin time — in patients of groups 1 and 2 compared with the data obtained in the control group (p<0.001). An increase in the content of soluble fbrin- monomer complexes and D-dimers was recorded in the blood plasma of patients of the 1st and 2nd groups compared to their level in the control group (p<0.001). Conclusion. The data of local coagulogram tests in patients requiring revision arthroplasty of the knee joint refect the signs of maladaptation in the hemostatic system at the preoperative stage of examination. It is worth noting the lack of information content of the screening coagulogram, as its basic tests do not refect changes in the whole system of homeostasis, the search for new informative research methods remains relevant today.

Keywords: —

Bibliography:
1 Quintana J, Arostegui I, Escobar A, et al. Prevalence of knee and hip osteoarthritis and the appropriateness of joint replacement in an older population. Arch Intern Med 2008; 168 (14): 1576–84
2 Kurtz S, Ong K, Lau E, et al. Projections of primary and revision hip and knee arthroplasty in the United States from 2005 to 2030 J Bone Joint Surg Am 2007; 89 (4): 780–85
3 Bozic K, Kurtz S, Lau E, et al. The epidemiology of revision total knee arthroplasty in the United States. Clin Orthop Relat Res 2010; 468 (1): 45–51
4 Singh A, Nicoll D. Complications and re-operation rates after revision total knee replacement. Orthopaedic Proceedings 2013; 95-B (31)
5 Matthews P, Berendt A, McNally M, et al. Diagnosis and management of prosthetic joint infection. BMJ 2009; 338: 1378–83
6 Pagnano M, Cushner FD, Hansen A, et al. Blood management in two-stage revision knee arthroplasty for deep prosthetic infection. Clin Orthop Relat Res 1999; 367: 238–42
7 Kulyaba TA, Kornilov NN, Selin AV, et al. The ways of bone defects compensation in revision knee arthroplasty. Traumatology and Orthopedics of Russia 2011; 3 (61): 5–12
8 Bozic KJ, Lau E, Kurtz S et al. Patient-related risk factors for postoperative mortality and periprosthetic joint infection in medicare patients undergoing TKA. Clin Orthop Relat Res 2012; 470 (1): 130–7
9 Berbari EF, Hanssen AD, Dufy MC et al. Risk factors for prosthetic joint infection: case-control study. Clin Infect Dis 1998; 27 (5): 1247–54
10 Liu, et al. Changes in coagulation functions and hemorheological parameters may predict hematoma formation after total knee arthroplasty. Journal of Orthopaedic Surgery and Research 2016; 11: 35
11 Stephen F Hughes, et al. Lower limb orthopaedic surgery results in changes to coagulation and non-specifc infam-matory biomarkers, including selective clinical outcome measures. Eur J Med Res 2013; 18 (1): 40
12 Muñoz M, García-Erce JA, Cuenca J, Solano VM. Course of D-dimer concentrations after total knee replacement surgery: efect of allogeneic and unwashed drainage blood transfusion. Trans Alternatives in Trans Med 2006; 8: 135–41.

AttachmentSize
2019_02_266-271.pdf1.45 MB
All articles of the authors: Shpinyak S.P., Shakhmartova S.G. , Puchinyan D.M. , Mandrov A.V., Kozadayev M.N. , Girkalo M.V.

No votes yet