Saratov JOURNAL of Medical and Scientific Research

The study on the refraction of morphofunctional changes in kidneys of white male rats with experimental light desynchronosis

Year: 2018, volume 14 Issue: №3 Pages: 363-367
Heading: Physiology and Pathophysiology Article type: Original article
Authors: Zlobina O.V., Ivanov A.N., Antonova V.M., Milashevskaya T.V., Bugaeva I.O.
Organization: Saratov State Medical University

The goal is to study the morphofunctional changes in the kidneys under the influence of light desynchronosis, an analysis of the degree of reversibility of these changes. Material and Methods. The study was carried out in two stages on 72 white male rats. In the first series of experiments, animals underwent round-the-clock light exposure for 10 and 21 days. In the second series after round-the-clock exposure to light for 10 and 21 days, the beings were exposed to natural light for 21 days. The animals of the control group were kept in a natural light regime. Morphological and morphometric analysis of histological sections of kidneys stained with hematoxylin and eosin was performed. Results. It was found that on the 10th day of the experiment, cellular infiltration of the cortex occurs, and the edema of the interstitial tissue develops. These changes progress to the 21st day of the experiment and are combined with a significant decrease in the area of the glomerular capillary network and expansion of the lumen of the capsule of the glomerulus of cortical nephrons. When assessing the long-term consequences after 10-day illumination, the diameter of the renal corpus is reduced along the long and short axis. The changes registered on the 21st day do not reach the control values, which indicate that they are irreversible. Conclusion. The revealed structural and functional changes in the kidney indicate a negative effect of light desynchronosis: 10-day lighting leads to a breakdown of compensatory possibilities and the development of distant morphological changes; long-term light exposure (within 21 days) leads to the development of pronounced irreversible structural disorders.

1. Anisimov VN, Vinogradova IA, Panchenko AV, et al. Light-at-night-induced circadian disruption, cancer and aging. Current Aging Science 2012; 5 (3): 170-7
2. Antonova VM, Zlobina OV, Ivanov AN, et al. Morphofunctional state of the kidneys in the stage of structural disturbances of light desynchronosis in the experiment. Modern problems of science and education 2017; 1
3. Ivanov AN, Zlobina OV, Zhurkin Kl, et al. Changes in microcirculation during experimental light desynchronosis. Regional blood circulation and microcirculation 2017; 1 (61): 43-8
4. Zlobina OV, Antipova ON, Bugaeva IO, et al. Stress-dependent disorders in light desynchronosis in an experiment on white male rats. In: Actual problems of scientific research: Collection of proceedings on the materials of the XVII International Scientific and Practical Conference. Ivanovo, 2017; p. 44-6
5. Zlobina OV, Slyusarenko YuA, Usoltseva ED. Morphofunctional state of testicles under the influence of light desynchronosis in the experiment. Actual problems of scientific research: Collection of proceedings on the materials of the XVII International Scientific and Practical Conference. Ivanovo, 2017; p. 52-4
6. Ageeva LI, Aleksandrova GA, Zaychenko NM, et al. Morbidity of the population in the main classes, groups and issues of the disease. Healthcare in Russia: Statistical collection. Moscow, 2017; p. 29
7. Nair V, Komorowsky CV, Weil EJ, et al. A molecular morphometric approach to diabetic kidney disease can link structure to function and outcome. Kidney International 2018; 93 (2): 439-49
8. Khan Z, Ngo JP, Le B, et al. Three-dimensional morphometric analysis of the renal vasculature. Imaging Techniques in Renal (patho) Physiology Research 2018; 314 (5): 715-25
9. Maslyakova GN, Napsheva AM. Morphology of chronic kidney disease caused by urolithiasis. Bulletin of medical Internet conferences 2013; 3 (4): 852-5
10. Kaladze NN, Slobodyan El, Govdaluk AL. Epiphyseal hormone melatonin and chronic kidney disease (review of literature and own research). Child Health 2015; 2 (61): 183-8
11. RazygraevAV, Kerkeshko GO, Harutyunyan AV. Routes of circadian control of the production of gonadotropin-releasing hormone. Journal of Obstetrics and Women's Diseases 2011; (2): 88-98
12. Ivanov AN. The change in the activity of stress-realizing systems of the organism under the influence of irradiation with terahertz waves at nitric oxide frequencies in white rats under acute stress. Bulletin of Experimental Biology and Medicine 2012; 154(9): 286-98
13. Savin IA, Goryachev AS. Water-electrolyte disturbances in neuroreanimation. Moscow: N. N. Burdenko Research Institute of Neurosurgery, 2016; p. 125-61/

2018_3_363-367.pdf516.04 KB

No votes yet