Saratov JOURNAL of Medical and Scientific Research

Erythrocyte system in elderly: ageing aspects

Year: 2018, volume 14 Issue: №2 Pages: 341-345
Heading: Gerontology and geriatrics Article type: Original article
Authors: Malinova L.I., Denisova Т.Р., Lipatova Т.Е., Khvostikova D.E., Yegorova A.V.
Organization: Saratov State Medical University
Summary:

The purpose of the study was an assessment of erythrocyte system age-dependent characteristics in elderly population dwelling in the same territory during the time period equal to the average life span in the region. Material and Methods. We perform the compare of hematological parameters of 800 patients with hypertension and coronary heart disease hospitalized during 25-years period. Results. In senile patients, red blood cells and hemoglobin levels signifi- cantly decrease, but platelet characteristics remain intact. Revealed differenced are similar during all 25-year period of observation. Conclusion. Over the past 25 years, the trend of age-related decline in the number of red blood cells and hemoglobin has been preserved. The average hemoglobin content in erythrocyte (MCH) during the aging process tends to decrease, which has become statistically significant in recent years. The principal difference of the obtained data from the results of obtained 25 years ago is the absence of an age-related increase in the volume of erythrocytes and a higher level of the average concentration of hemoglobin in the erythrocyte.

Bibliography:
1. Chernigovskiy VN, Moiseeva Ol. Regulation of erythropoiesis. Successes of the physiological sciences 1982; 13: 27-44
2. Funasako М, Fujimoto К, Taniji М, et al. Effect of ageing on erythrocyte aldose reductase and sorbitol dehydrogenase activity. Mech Ageing Dev 1994; 73: 137-43
3. Gradinaru D, Margina D, Hie M, Borsa C, lonescu C, Prada Gl. Correlation between erythropoietin serum levels and erythrocyte susceptibility to lipid peroxidation in elderly with type 2 diabetes. Acta physiologica Hungarica 2015; 102: 400-8
4. Htoo MS, Kofkoff RL, Freedman ML. Erythrocyte parameters in the elderly: an argument against new geriatric normal values. J Am Geriatr Soc 1979; 27: 547-51
5. Pandey KB, Jha R, Rizvi SI. Erythrocyte membrane transporters during human ageing: modulatory role of tea catechins. Clin Exp Pharmacol Physiol 2013; 40: 83-9
6. Vasarhelyi B, Debreczeni LA. Lab Test Findings in the Elderly. EJIFCC 2017; 28: 328-32
7. Foller M, Kaestner L, Straface E, Vogel J. Erythrocytes and erythropoietin. Int J Cell Biol 2011; 2011: 972536
8. Kashiba M, Inoue M. Nitric oxide-independent effects of nitric oxide donors on energy metabolism in erythrocytes. Biochem Pharmacol 2000; 59: 557-61
9. Bateman RM, Jagger JE, Sharpe MD, Ellsworth ML, Mehta S, Ellis CG. Erythrocyte deformability is a nitric oxide-mediated factor in decreased capillary density during sepsis. Am J Physiol Heart Circ Physiol 2001; 280: H2848-56
10. Bovenberg SA, Klop B, Alipour A, et al. Erythrocyte-associated apolipoprotein В and its relationship with clinical and subclinical atherosclerosis. Eur J Clin Invest 2012; 42: 365-70
11. Denisova TP, Malinov IA, Malinova LI, Brook SB. Usage of analytical representations of time functions of some parameters of blood for early diagnostics of an internal pathology. Proc. SPIE. 4001, Saratov Fall Meeting '99: Optical Technologies in Biophysics and Medicine (6 April 2000). DOI: 10.1117/12.381525
12. Park SE, Kim H, Lee J, et al. Decreased hemoglobin levels, cerebral small-vessel disease, and cortical atrophy: among cognitively normal elderly women and men. Int Psychogeriatr 2016; 28: 147-56
13. Hanafusa N, Nomura T, Hasegawa T, Nangaku M. Age and anemia management: relationship of hemoglobin levels with mortality might differ between elderly and nonelderly hemodialysis patients. Nephrol Dial Transplant 2014; 29: 2316-26
14. Dong X, Mendes de Leon C, Artz A, Tang Y, Shah R, Evans D. A population-based study of hemoglobin, race, and mortality in elderly persons. J Gerontol A Biol Sci Med Sci 2008; 63: 873-8
15. Tatsumi J, Hiyoshi M, Yokomatsu Y, et al. [Evaluation of new hematologic parameters, RDW (red cell distribution width) and HDW (hemoglobin concentration distribution width), in anemia in the elderly]. [Rinsho ketsueki]. The Japanese journal of clinical hematology 1987; 28: 16-21
16. Vorobyev PA, Gorokhova SG. Heart Ischemia in Old Age. Clinical Gerontology 2002; 8: 28-33
17. Klein RM, Vester EG, Brehm MU, et al. [Inflammation of the myocardium as an arrhythmia trigger]. Z Kardiol 2000; 89 (Suppl 3): 24-35
18. Goi G, Cazzola R, Tringali C, et al. Erythrocyte membrane alterations during ageing affect beta-D-glucuronidase and neutral sialidase in elderly healthy subjects. Exp Gerontol 2005;40:219-25.

AttachmentSize
2018_2-1_341-345.pdf291.29 KB

No votes yet