Qualitative and quantitative comparisons of bone PET-imaging using 68Ga-oxabiphor and Na18F
Heading: radiation medicine Article type: Original article
Authors: Lunyov A.S., Clement'eva О.Е., Lunyova К.А., Zhukova M.V., Malysheva А.О.
Organization: State Scientific Research Center n.a. A.I. Burnasyan — Federal Medical Biophysical Center of Federal Medical Biological Agency
The aim of the study is to compare qualitative and quantitative characteristics of the experimental mice bone pathology using of Na18F and prospective radiotracer"Oxabigal, 68Ga" (complex of gallium-68 with oxa-bys-ethylenenitrile tetra (methylene phosphonic acid). Material and Methods. 30 nonlinear mice-female with the model of bone pathology were used in the experiment. Na18F and "Oxabigal, 68Ga" were injected to animals (i.v). Then mice were scanned using PET-imaging with subsequent calculation of pharmacokinetics parameters. Results. The intravenous injection of two radiotracers enabled to visualize of simulated bone pathology using PET. Conclusion. The experimental pathological foci were able to visualize within the first hour after i.v using of the "Oxabigal, 68Ga" and Na18F. There is a statistically significant difference between blood accumulation of radiopharmaceuticals labeled different radionuclides. However the difference doesn't matter for positive results we have got. 68Ga-labeled bone-seeking radiopharmaceuticals and its generator producing method are important supplement for independent choice of using different radiotracers for PET-imaging (such as Na18F) of bone pathology.
Bibliography:
1. Modnikov OP, Novikov GA, Rodionov VV. Bone metastases of breast cancer: pathogenesis, clinics, diagnostics and treatment. Moscow, 2001; 256 p.
2. Rybak LD, Rosental Dl. Radiological imaging for the diagnosis of bone metastases. Q J Nucl Med 2001; 45: 53-64
3. Uchida N.Sugimura K, KajitaniA, YoshizakoT, IshidaT. MR imaging of vertebral metastases: evaluation of fat saturation imaging. Eur J Radiol 1993; 17: 91-94
4. Harbert JC, Eckelman WC, Neumann RD. Nuclear Medicine: Diagnosis and Therapy. New York: Thieme Medical Publishers Inc, 1996
5. McAfee G.Tc-99m-methylenediphosphonate — a superior agent for skeletal imaging: comparison with other technetium complexes. J Nucl Med 1975; 16: 744
6. Ebetino FH, Barnett BL, Russell RGG. A computational model delineates differences in hydroxyapatite binding affinities of bisphosphonate. J Bone Miner Res 2005; 20 (1): 259
7. Blau M, Ganatra R, Bender MA. 18F-Fluoride for bone imaging. Semin Nucl Med 1972; 2: 31-37
8. Bateman TM. Advantage sand disadvantages of PET and SPECT in a busy clinical practice. J Nucl Cardiol 2012; 19 (2): 3-11
9. Grant FD, Fahey FH, Packard AB, DavisRT.AIaviA, Treves ST. Skeletal PET with 18F-Fluoride: Applying New Technology to an Old Tracer. J Nucl Med 2008; 49: 68-78
10. Breeman WAP, Verbruggen AM. The 68Ge/68Ga generator has high potential, but when can we use 68Ga-label led tracer sin clinical routine? Eur J Nucl Med Mol Imaging 2007; 34: 978-81
11. Fellner M, Baum RP, Kubicek V. PET/CT imaging of osteoblastic bone metastases with 68Ga-bisphosphonates: first human study. Eur J Nucl Med Mol Imaging 2010; 37: 834-834
12. Suzuki K, Satake M, Suwada J. Synthesis and evaluation of a novel 68Ga-chelate-conjugated bisphosphonate as a bone-seeking agent for PET imaging. Nucl Med Biol 2011; 38 (7):1011-8
13. Ogawa K, Takai K, Kanbara H. Preparation and evaluation of a radiogallium complex-conjugated bisphosphonate as a bone scintigraphy agent. Nucl Med Biol 2011; 38: 631 -6
14. Goulet RT, Shysh A, Noujaim AA, Lentle BO Investigation of 68Ga tripolyphosphate as a potential bone scanning agent. Int J App Rad and Isotopes 1975; 26 (4): 195-9
15. Patent RU No 2522892
16. Phelps ME. Positron emission tomography provides molecular imaging of biological processes. Proc Nat Acad Sci USA 2000; 97: 9226-33.
17. Herschman HR, MacLaren DC, Iyer M. Seeing is believing: non-invasive, quantitative and repetitive imaging of reporter gene expression in living animals, using positron emission tomography. J Neuro Sci Res 2000; 59: 699-705.
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