Nail psoriasis: the first experience of photodynamic curcumin therapy.
Year: 2017, volume 13 Issue: №3 Pages: 600-604
Heading: Dermatovenerology Article type: Original article
Authors: Utz S.R., Tal'nikova Е.Е., Sultanakhmedov E.S., Myasnikova T.D., Safonov V.A., Popovicheva O.A.
Organization: Saratov state university, Saratov State Medical University
Heading: Dermatovenerology Article type: Original article
Authors: Utz S.R., Tal'nikova Е.Е., Sultanakhmedov E.S., Myasnikova T.D., Safonov V.A., Popovicheva O.A.
Organization: Saratov state university, Saratov State Medical University
Summary:
Aim: to determine the effectiveness of the photosensitizer "Curcumin" in various concentrations (0.15%, 1%, 1.5%) in combination with visible spectrum radiation in the treatment of nail psoriasis. Material and Methods. 6 patients (4 women and 2 men) of different age groups (from 20 to 50 years) with the established diagnosis of "Psoriasis" were observed. The study was carried out using the "Curcumin" photosensitizer solution, the broadband spectrometer "Ocean Optics USB4F01891", the LS-55 spectrometer, the PhotoDyn-750 and the THORLABS PM100D. To assess the dynamics of the pathological process, the N-NAIL Index was used. Results. The most pronounced and clinically significant changes were detected when using a 1.5% solution of the "Curcumin" photosensitizer. Conclusion. The photosensitive agent "Curcumin" is effective in photodynamic therapy of psoriasis of the nails.
Bibliography:
1. Yorulmaz A, Artuz F. A study of dermoscopic features of nail psoriasis. Adv Dermatol Allergol 2017; 34 (1): 28-35
2. Langley RG, Krueger GG, Griffiths CE. Psoriasis: epidemiology, clinical features, and quality of life. Ann Rheum Dis 2005; 64 (2): 1
-23
3. Rich P, Scher RK. Nail Psoriasis Severity Index: A useful tool for evaluation of nail psoriasis. J Am Acad Dermatol 2003; 49: 206-12
4. Zachariae R, Zachariae H, Blomqvist K, et al. Quality of life in 6497 Nordic patients with psoriasis. Br J Dermatol 2002; 146: 1006-16
5. De Arruda LH, De MoraesAP The impact of psoriasis on quality of life. Br J Dermatol 2001; 144 (58): 33-6
6. KreugerG, Koo J, Lebwohl M, et al.The impact of psoriasis on quality of life: results of a 1998 National Psoriasis Foundation patient-membership survey. Arch Dermatol 2001; 137: 280-4
7. De Jong EM, Seegers BA, Gulinck MK, et al. Psoriasis of the nails associated with disability in a large number of patients: results of a recent interview with 1728 patients. Dermatology 1996; 193:300-3.
8. Haneke E. Nail psoriasis: clinical features, pathogenesis, differential diagnoses, and management. Psoriasis: Targets and Therapy 2017; 7: 51-63
9. Rigopoulos D, Papanagiotou V, Daniel III R, et al. Onychomycosis in patients with nail psoriasis: a point to point discussion. Mycoses 2016; 1-5
10. Jiaravuthisan MM, Sasseville D, Vender RB. Psoriasis of the nail: anatomy, pathology, clinical presentation and a review of the literature on therapy. J Am Acad Dermatol 2007; 57: 1-27
11. Regafia SM, Iglesias M, Creus L, et al. Prevalencia de enfermedades hepaticas cronicas en pacientes con psoriasis. Actas Dermosifiliogr 2000; 91: 498-510
12. Sanchez-Regana M, Umbert P. Diagnosis and Management of Nail Psoriasis Actas Dermosifiliogr 2008; 99: 34-43
13. Sharada RG, Jayakar T. A study on psoriasis of nails-severity scoring system. ARC Journal of Dermatology 2016; 1 (2): 13-16
14. Bhatta AK, Keyal U, Wang XL. Photodynamic therapy for onychomycosis: A systematic review. Photodiagnosis and Photodynamic Therapy 2016; 15: 228-235
15. Hamblin MR, Huang YY. Handbook of photomedicine. CRC Press 2014: 815
16. Choi YM, Adelzadeh L, Wu JJ. Photodynamic therapy for psoriasis. J Dermatolog Treat 2015; 26 (3): 202-7
17. Wiznia LE, Quatrano NA, Mu EW. A Clinical Review of Laser and Light Therapy for Nail Psoriasis and Onychomycosis. Dermatol Surg 2017; 43: 161-172
18. TawfikAA. Novel treatment of nail psoriasis using the intense pulsed light: a one-year follow-up study. Dermatol Surg 2014;40:763-8
19. Fernandez-Guarino M, Harto A, Sanchez-Ronco M, et al. Pulsed dye laser vs. photodynamic therapy in the treatment of refractory nail psoriasis: a comparative pilot study. J EurAcad Dermatol Venereol 2009; 23: 891-5
20. Olbricht SM, Stern RS, Tang SV et al. Complications of cutaneous laser surgery: A survey. Arch Dermatol 1987; 123: 345-9
21. Nanni CA, Alster TS. Complications of cutaneous laser surgery: A review. Dermatol Surg 1998; 24: 209-19
22. Jin Y, Zhang X, Zhang B, et al. Nanostructures of an amphiphilic zinc phthalocyanine polymerconjugate for photodynamic therapy of psoriasis. Colloids and Surfaces B: Biointerfaces 2015; 128: 405-9
23. Sharman WM, Allen CM, van Lier JE. Photodynamic therapeutics: basic principles and clinical applications. DDT 1999; 4 (11): 507-17
24. Richard EG, Hbnigsmann H. Phototherapy, psoriasis, and the age of biologies. Photodermatol, Photoimmunol & Photomed 2014; 30(1): 3-7
25. Anand P, Kunnumakkara AB, Newman RA, Aggarwal BB. Bioavailability of Curcumin: Problems and Promises. Molecular Pharmaceutics 2007; 4 (6): 807-18
26. Dujic J, Kippenberg S, Hoffmann S, et al. Low concentrations of curcumin induce growth arrest and apoptosis in skin keratinocytes only in combination with UVA or visible light. J Invest Dermatol 2007; 127: 1992-2000
27. Dujic J, Kippenberger S, Ramirez-Bosca A. et al. Curcumin in combination with visible light inhibits tumor growth in a xenograft tumor model. Int J Cancer 2009; 124: 1422-8
28. Bernd A, Theilig C, Kippenberg S, et al. An extract of Curcuma longa exerts antioxidative, antiinflamatory and antiproliferative effects on human keratinocytes in vitro. J Invest Dermatol 1997; 109:460
29. Bernd A, Theilig C, Kippenberg S, et al. Effects of Curcuma longa extract on the expression of proinflammatory citokines. Skin Pharmacol Apll Skin Physiol 2000; 13: 226
30. AsHn-LLorca M, RamHrez-Bosc A, Miquel J, et al. Ensayo clHnico piloto no controlado de eficacia de 600mg/dHa de Extracto de Curcuma estandarizado al 12% en curcumina en el tratamiento de pacientes con psoriasis crynica en placas moderada-grave. EUDRACT N 2006; 3395-35.
31. Utz SR, Talnikova ЕЕ. Curcumin usage in dermatology (review). Saratov Journal of Medical Scientific Research 2016; 12 (3): 484-87. Russian (Утц С. Р,Тальникова E.E. Применение куркумина в дерматологии. Саратовский научно-медицинский журнал 2016; 12 (3): 484-87).
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