Saratov JOURNAL of Medical and Scientific Research

The far long-wave ultraviolet lichen planus therapy with the use of clearing agents

Year: 2017, volume 13 Issue: №3 Pages: 579-585
Heading: Dermatovenerology Article type: Original article
Authors: Artemina ЕМ, Utz SR, Zimnyakov DA, Slesarenko NA, Yuvchenko SA.
Organization: Saratov State Technical University n.a. Yu.A. Gagarin, Saratov State Medical University
Summary:

 The goal: to increase the effectiveness of far long-wave ultraviolet therapy in patients with lichen planus using immersion agents. Materials and Methods. The study included 50 patients aged from 18 to 65 years with typical and hypertrophic forms of lichen planus who had received UVA1-therapy. All the patients were divided into 2 groups: in the 1-st group before the phototherapy on the elements of lichen planus caused an clearing agent propylene glycol (PG) and in the 2nd group PG was not used. The dynamics of the enlightenment of the skin was assessed using optical coherence tomography. After the end of treatment was a decrease in mean group values of ILP 96% of the original value, pruritic index 98%, DLQI 87% respectively. Results. In the 1-st group patients occurred more rapid resolution of the pathological process, the rate of phototherapy was 15-20 procedures. In the 2nd group to complete resolution of the pathological process, required an increase in the number of procedures to 20-25. Conclusion. Far long-wave UV therapy showed high efficacy and compliance in patients with lichen planus, the use of the 1,2-PG allowed to shorten the duration of treatment of patients.

Bibliography:
1. Kubanova AA, ed. Dermatovenerologiya: Klinicheskie rekomendacii. Moscow: DEKS-Press, 2010; 428 p.
2. Dovzhanskij SI, Slesarenko NA, Utz SR. Krasny'j ploskij lishaj. Saratov: SGML), 2013; 247 p.
3. Rebora A. (Kaczambas AD, Lotti ТМ, eds.) Ploskij lishaj: Evropejskoe rukovodstvo po lecheniyu dermatologicheskix boleznej. Moscow: MEDpress-inform, 2008; p. 371-374
4. Castro Jacques С. De Moura, Cardozo Pereira AL, Cabral MG, Cardoso AS, et al. Oral lichen planus part I: epidemiology, clinics, etiology, immunopathogeny, and diagnosis. Skinmed 2003; 2 (6): 342-349
5. Ivanova EV, Tupitsyn NN, Rabinovich IM, Rabinovich OF. The lymphocyte subpopulations of oral mucous capsule affected with lichen planus. Immunology 2007; (28): 31-34
6. Slesarenko NA, Utz SR, Artemina EM, et al. Comorbidity in patients with lichen ruber planus. Klinitceskaya dermatologiya i venerologiya 2014; (5): 4-9
7. Reshetnikova ЕМ, Utz SR, Slesarenko NA. Phototherapy in complex treatment of patients with lichen planus. Saratov Journal of Medical Scientific Research 2013; 9 (3): 530-533
8. Slesarenko NA, Reshetnikova ЕМ, Reznikova MA. Comparative Analysis of Different Types of Phototherapy in Patients with Lichen Planus. Proceedings of Saratov State University. New Series. Physics 2013; 13 (1): 55-57
9. Bakulev AL, Platonova AN, Rasskazov YA, Alipov N.V. Efficiency of UVA1-therapy in complex treatment of chronic dermatosis. Vestnik Dermatologii i Venerologii 2012; 4: 64-69
10. Sakakibara N, Sugano S, Morita A. Ultra-structural changes induced in cutaneous collagen by ultraviolet-A1 and psoralen plus ultraviolet A therapy in systemic sclerosis. Jpn J Dermatol 2008; 35: 63-9
11. Mouret S, Philippe C, Gracia-Chantegrel J, et al. UVA induced cyclobutane pyrimidine dimers in DNA: a direct photochemical mechanism? Org Biomol Chem 2010; 8:1706-11
12. Yamauchi R, Morita A, Yasuda Y, et al. Different susceptibility of malignant versus nonmalignant human T cells toward ultraviolet A-1 radiation-induced apoptosis. J Invest Dermatol 2004; 122: 477-83
13. Brem R, Karran P. Multiple forms of DNA damage caused by UVA photoactivation of DNA 6-thioguanine. Photochem Photobiol 2011; 88: 5-13
14. Choi B, Tsu L, Chen E, et al. Determination of chemical agent optical clearing potential using in vitro human skin. Lasers Surg Med 2005; 36: 72-75
15. Zimnykov DA, Simonenko GV, Tuchin VV. Dispersion dependence of the optical anisotropy and the degree of depolarization of fibrous tissues Journal of Optical Technology 2010; 77 (9): 577-581
16. Jiang J, Wang R. Comparing the synergistic effects of oleic acid and dimethylsulfoxide as vehicles for optical clearing of skin tissue in vitro. Phys Med Biol 2004; 49: 5283-5294
17. Hirshburg J, Choi B, Nelson JS. Correlation between collagen solubility and skin optical clearing using sugars. Laser Surg Med 2007; 39: 140-144
18. Rylander CG, Stumpp OF, Milner ТЕ, et al. Dehydration mechanism of optical clearing in tissue. J Biomed Opt 2006; 11 (4): 41-43
19. Utz SR, Tuchin VV, Galkina EM. The dynamics of some human skin biophysical parameters in the process of optical clearing after hyperosmotic solutions topical application. Vestnik Dermatologii i Venerologii 2015; (4): 60-68
20. Genina ЕА, Bashkatov AN, Sinichkin YP, Tuchin VV. Optical clearing of the eye sclera in vivo caused by glucose. Quantum Electronics 2006; 36 (12): 1119-1124
21. Bashkatov AN, Genina ЕА, Sinichkin YuP, Tuchin VV. The influence of glycerol on the transport of light in the skin. Proc SPIE 2002; 4623: 144-152
22. Artemina EM, Utz SR, Yuvchenko SA, et al. Comparative evaluation of clarifying agents to improve the quality of the far long-wave ultraviolet therapy chronic dermatosis. Saratov Journal of Medical Scientific Research 2016; 12 (3): 453-458
23. Wang RK, Tuchin VV. Enhance light penetration in tissue for high resolution optical imaging techniques by the use of biocompatible chemical agents. Journal of X-ray Science and Technology 2002; 10(3): 167-176
24. Zhi Z, et al. Improve optical clearing of skin in vitro with propylene glycol as a penetration enhancer. Journal of Innovative Optical Health Sciences 2009; 2 (3): 269-278
25. Trommer H, Neubert RH. Overcoming the stratum corneum: the modulation of skin penetration. Skin pharmacology and physiology 2006; 19 (2): 106-121
26. Williams AC, Barry BW Penetration enhancers. Advanced drug delivery reviews 2012; 64: 128-137
27. Lessmann H, etal. Skin-sensitizing and irritant properties of propylene glycol. Contact dermatitis 2005; 53 (5): 247-259
28. Nair B, Elmore AR. Cosmetic Ingredients Review Expert Panel. Final report on the safety assessment of sodium sulfite, potassium sulfite, ammonium sulfite, sodium bisulfite, ammonium bisulfite, sodium metabisulfite and potassium metabisulfite. Int J Toxicol 2003; 22 (2): 63-88
29. Tuchin VV. Enhance light penetration in tissue for high resolution optical imaging techniques by the use of biocompatible chemical agents. Journal of X-ray Science and Technology 2002; 10(3): 167-176.

AttachmentSize
2017_03-1_579-585.pdf1.12 MB

No votes yet