№2, 2017, volume 13

The review analyzes the modern studies of domestic and foreign authors dedicated to the definition of the category of pharmaceutical care and study of its role in maintaining the health of the population. Pharmaceutical care has social, cultural and historical conditionality and can be considered as one of the essential elements of the public health system. Formation of market relations in the Russian society contributed to significant changes in the population attitude to their health, the conversion of existing objective laws of functioning of public health (traditionally non-market sector), and the conditions of activities of medical organizations and specialists.

Demographic situation at the global and regional levels is designated by social context and social mechanisms. The probability of a certain pathological state may increase under the influence of factors, most of which can be considered as socially determined. Poverty and health care limited availability are considered by the authors in the context of the risk of the formation of a marginal situation for patients with chronic diseases, which is manifested in adaptation crisis, disability of the patient in a situation of chronic disease.

Purpose: interdisciplinary analysis of quality of life and objectifying strategies of medico-social rehabilitation of children-orphans in conditions of illness. Material and Methods. Included in the study on a random sample of 354 respondents aged 14-18 years of age (160 males and 194 female). The study of quality of life was conducted using the international questionnaire of WHOQOL-100. Statistical significance of differences of average indices of life quality of groups of respondents was determined by non-parametric Mann —Whitney test. Results. Analysis of the averages of quality of life in the group of clinically healthy respondents were allowed to define the indices on average significantly (p<0.01 — p<0.05) different in the group of children-orphans and children living in families. During the research it was found that the average quality of life of orphans in a situation of a disease in most points of questionnaire were significantly lower than in the control group. Statistically significant differences of average values of indicators of quality of life in the analysis of the quality of life of the respondents (orphans and children living in families) in the case of illness related to the effects of disease and child abandonment, somatically and socially determined. Conclusion. Established in the course of the study the statistical relationship between indicators of quality of life from disease and the effectiveness of re-socialization proves the possibility of the objectification of recovery strategies and the formation of personally identifiable medical and social assistance to children-orphans in conditions of illness.

This work contains the model of forming the students' value priorities on healthy lifestyle based on the following levels: influence of the government, influence of the educational institution, influence of surrounding community, and self-motivation. The analysis of government motivation system used in Russia is given as well as how this policy integrated into the activities of the educational institution (on example of Saratov State Medical University n.a. V. I. Razumovsky).

Aim: to analyze the correlation between the unfavorable factors at newborn patients and children and the peculiarities of the course of urolithiasis in adults. Material and Methods. The data were received from questioning of 286 patients and their relatives, analysis of case histories and past medical histories. The material was statistically worked out. Results. The early development of urolithiasis (at patients under 30) was associated with the threat of termination of pregnancy, prematurity, excretory and digestive disorders at childhood in case of severe anamnesis of urolithiasis, and also malnutrition. Bilateral lesions of the urinary system were determined to be associated with artificial feeding and prematurity, digestive diseases and complicated anamnesis of urolithiasis, malnutrition, deprived living conditions and low income. Stones in calyces occurred at patients with different complications at birth. More frequent cases of stone formation in renal pelvis were observed at premature and malnutrition patients and patients with cardiovascular diseases occurred during the childhood. Stones in ureters were considered as a result of respiratory diseases effect. Conclusion. Unfavorable factors occurred at birth and childhood, factors concerned with deprived social conditions and psychological problems influence the onset and the course of urolithiasis.

The frequency of knee arthroplasty in knee arthritis is forcing the orthopedic community to take measures to optimize this surgical intervention. Despite the fact that this is a routine operation, it is often accompanied by significant blood loss. Large intraoperative blood loss leads to the development of postoperative post-hemorrhagic anemia which is an extremely unfavorable effect in the course of wound healing, moreover, it affects the length of stay of a patient in clinic and the cost of treatment. The analysis of the literature on the issue of patient blood loss management tells of divergent efforts of experts in related fields of medicine and complex multi-disciplinary research on this topic, often — with contradictory conclusions. It can be noted that nowadays there is no accurate, reliable and scientifically proven sound algorithm of blood loss management in primary total knee arthroplasty in modern Russian and foreign literature.

Aim: study of diagnostic value of different assessment scales to evaluate outcomes of surgeries in degenerative and post-injury deformities of cervical spine. Material and Methods. Between January and December 2015, 110 consecutive patients with degenerative and traumatic lesions of cervical spine were selected for surgery and results of treatment were followed. Preoperatively and 12 months postoperatively the patients filled in a questionnaire that included a VAS, Odom's scale, NDI, modified JOAand the Zung Depression Scale. To assess the results of the intervention, the concept of "effect size" was used. Distribution of different scores classified according to Odom's criteria as excellent/good and fair/poor. Results. All scores improved in all group of patients. For VAS, NDI and modified JOA scores the effect size was largest. NDI, JOAand ZDS seemed to correlate well with the classification of outcome by Odom. Conclusion. It is suggested many scales to assess the outcomes of the cervical spine surgery based on different criteria; nevertheless, there are no generally accepted and validated methods that can be used to analysis the outcome of cervical spine surgery. We conclude that investigated

The objective: the study analyses the features of spontaneous growth of hydroxyapatite crystals on dentinal substrate using (by the use of) artificially grown Zn-hydroxyapatite combined with ultrasonic treatment. Material and Methods. A dynamic study of dentinal substrate structure was conducted in a certain time interval after standard primary surface treatment of dentin micro-sections, divided into control and experimental groups. Dentin surfaces in the second group were covered by finely dispersed Zn-hydroxyapatite in combination with ultrasonic treatment. The investigation was performed by use of analytical complex based on scanning electron microscope with high resolution SEM Mira II LMU (Tescan) and energy dispersive analysis system. Results. There were revealed the structural changes of dentinal substrate surface overtime period due to directional growth of Zn-hydroxyapatite crystals. Conclusion. The conducted study showed the possibility of formation of the stable structures in the dentinal substrate when using Zn-hydroxyapatite in combination with ultrasonic treatment.

Information on noninvasive biomarkers and methods for studying inflammatory bowel diseases in newborns has been summarized. It is based on the analysis of data taken from foreign and Russian literature. The need for additional study of factors affecting the level of fecal protein production in newborns is substantiated.

Objective: the combination frequency of BPD in premature infants, assessment of the degree of functional lesion of the respiratory tract and the efficiency of respiratory support. Material and Methods. The survey included 36 women and 38 preterm infants (two twins). Results. In 99% of the surveyed women pregnancy was complicated by chronic intrauterine fetal hypoxia, 2.1% — RH-conflict. At 43.2% of cases acute respiratory viral infection during pregnancy was revealed, 15.3% of bad obstetric history, 5% of women who had bad habits (smoking, alcohol intake). In 2015 there were 5 deaths (13.2%). 14 children (36.8%) were transferred to other hospitals for further treatment, the remaining 19 (50%) were discharged from the hospital. One child — full-term, the other— premature. At 87.7% of children with BPD, the diagnosis was RDS, in 4.2% — aspiration of meconium, 8.1% — congenital pneumonia. 15 children (30.5%) received therapy with surfactant once, including 9 newborns (23.7%) received medication twice. All newborns were carried out intensive care, including respiratory support. Mechanical ventilation in 14 children had been conducting for 8.4±2.3 day, in 13 cases for 17.3±3.8 day, in 11 cases for 23.4±4.1 day. Nasal CPAP was conducted in 23 newborns: from 4 to 6.8±1.9 day, 13 — less of 16.8±2.9 per day, 6 children have had more than 23.2±3.8 day. Conclusion. There is necessity for prevention during pregnancy with glucocorticoids, the prolongation of pregnancy; preterm neonates — surfactant therapy; adequate provision of resuscitation care in the delivery room and respiratory support. The reduction of time of mechanical ventilation and the expansion of the indications for non-invasive methods of respiratory therapy reduced the incidence of BPD, the severity of the disease and improve the prognosis.