The results of the treatment of various morphological types of ENT skin cancer by photodynamic therapy
Heading: Skin Diseases Article type:
Authors: Volgin V.N., Stranadko E.F., Kagoyants R.V.
Organization: Main Military Clinical Hospital n.a. Acad.N. N. Burdenko, Moscow, Armavir Oncology Dispensary
This article discusses one of the urgent problems of modern oncology — the question of treatment of skin cancer (SC). The experience of the new promising method of photodynamic therapy (PDT) in the treatment of patients with primary and recurrent skin cancer. Aim: to evaluate the effectiveness of photodynamic therapy (PDT) in the treatment of patients with primary and recurrent skin cancer (SC). Materials. The Main Military Clinical Hospital SC treatment of upper respiratory tract with PDT performed 108 patients: 85 men, 23 women. The age of patients ranged from 43 to 92 years, averaging 71 years. 96 patients were with basal cell skin cancer (BCC) in otolaryngology 8 patients were with squamous cell carcinoma of the skin (SCSC), 4 persons — with metatipichesky skin cancer (MSC). Results. In the treatment of patients with SC otolaryngology, PDT complete resorption (CR) was 89.8%, the partial resorption (PR) — 9.3%, no effect (NE) — 0.9%. The highest efficiency was obtained in the treatment method of PDT in patients with BCC otolaryngology — 92.7%. The least effective method of PDT in the treatment of upper respiratory tract SCSC — 62.5%. Disease-free outcome was noted in 88.7% of patients SC otolaryngology. In 11.3% of cases, relapse. The highest efficiency was obtained in the treatment method of PDT in patients with BCC otolaryngology — 89.9%. The least effective method of PDT in the treatment of upper respiratory tract MSC — 66.7%. Conclusion. PDT is an effective treatment RK ENT, unlike other methods of treatment of organ-character, excellent cosmetic and functional results, high selectivity of therapeutic action, the absence of severe systemic effects on the body. The advantage of PDT compared with other treatments SC ENT is also the possibility of multiple repeating the procedure in the case of large diameter and in multiple tumor malignancy without risk of complications.
Bibliography:
1. Panes A.l. Tumors of head and neck. 5th ed. M., 2013; 478 p.
2. Sergeev YV, Borisova SV, Shubina SI. Current problems of practical dermatooncology: increased incidence of disease, improved screening and prevention of basal cell skin cancer. Rossick Journe the skins and veins bol 1999; (1): 8-12
3. Stranadko EPh, Volgin VN, Lamotkin IA, et al. Photo-dynamic therapy of basal cell skin cancer with photosensitizer photodithazine. The Russian biotherapeutic journal. 2008; 7 (4):7-11
4. Stranadko EF, Volgin VN, Lamotkin IA, at al. Photodynam-ic therapy of basal cell skin cancer with second generation photosensitizer with foscan. Russian medical Bulletin 2009; XIV (1): 16-22
5. Taranets ТА, Sukhova IE, Romanko US. Photodynam-ic therapy of basal cell skin cancer with local and intravenous use of photosensitizer chlorin series "Photolon". Almanac of clinical medicine 2007; (15): 283-288
6. Chissov VI, Starinsky VV, Petrova GV Malignant neoplasms in Russia in 2003 (morbidity and mortality). M., 2005; 256
7. Sloeva Al. Is a method of photodynamic therapy in the treatment of certain primary and recurrent tumors in oto-rhinolaryngology: PhD abstract. M., 2004; 25 p.
8. Stranadko EPh. Mechanisms of action of photodynamic therapy
9. Stranadko EPh., Astrakhankina ТА. Photodynamic therapy of skin cancer. M., 1996; 11 p.
10. Stranadko EPh, MeshkovVM, RyabovMV, etal. Use pho-tobiological properties of porphyrins in clinical Oncology In: Proceedings of the II all-Russian Congress of Photobiologic. Pushchi-no, 1998; p. 402-405.
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