Saratov JOURNAL of Medical and Scientific Research

Pseudomonas infection: exotoxin A effect

Year: 2014, volume 10 Issue: №3 Pages: 542-546
Heading: Skin Diseases Article type: Review
Authors: Morrison A.V., Popovich V.I., Morrison V.V..
Organization: Central Scientific Research Experimental Institute 33, Saratov State Medical University

The aim of the article is to present the data analysis of the Russian and foreign literature concerning the current situation of the problem, the frequency and mechanisms of pseudomonas infection development and factors of patho-genicity of Pseudomonas aeruginosa. The mechanisms of exotoxin A effect have been under the study

1. Ilyukevich GV. Pseudomonas aeruginosa infection: New century with the problem researched. Medical news 2004; (12): 3-8
2. Rudnov VA. Modern clinical view on Pseudomonas aeruginosa infection and possibilities of the therapy in patients of resuscitation departments. Infections and antimicrobial therapy 2002; 4 (6): 32-40
3. Rudnov VA, Belsky DV, Dekhnich FV, Research group of resuscitation department. Infections at Resuscitation departments in Russia: results of national multicentral research. Clinical microbiology and microbial chemotherapy 2011; 13 (4): 294-303
4. Driscoll JA, Brody SL, Kollef MH. The epidemiology pathogenesis and treatment of Pseudomonas aeruginosa infections. Drugs 2007; 67 (3): 351-368
5. Vincent JL, Rello J, Marshall J, et al. EPIC II Group of Investigators. International study of the prevalence and outcomes of infection in intensive care units. JAMA 2009; 302 (21): 2323-2329
6. Ratjen F, Doring G, and Nikolaizik WH. Effect of inhaled tobramycin on early Pseudomonas aeruginosa colonisation in patients with cystic fibrosis. Lancet 2001; 358 (9286): 983-984
7. Wu DC, Chan WW, Metelitsa Al, et al. Pseudomonas skin infection clinical features, epidemiology, and management. Am J Clin Dermatol2011; 12: 157-169. 8. Moroz AF, Antsiferova NG, Baskakova NV Pseudomonas aeruginosa infection. M.: Medicine, 1988: 256 p.)
9. Brook I, Frazier EH, Yeager JK. Microbiology of infected poison ivy dermatitis. Br J Dermatol 2000; 142 (5): 943-946
10. Petropoulou H, Giamarellos-Bourboulis EJ, Kavatzas N, et al. Early cutaneous alterations in experimental sepsis by Pseudomonas aeruginosa. Dermatology 2004; 209 (2): 111-116
11. SimonettiA, Ottaiano E, Diana MV, etal. Epidemiology of hospital-acquired infections in an adult intensive care unit: results of a prospective cohort study. Ann Ig 2013; 25 (4): 281-289
12. Reshedko GK, Ryabkova EL, Krechnikova 01. Resistency to antibiotics of gram-negative agents of nosocomial infections at resuscitation department in general hospitals of Russia. Clinical microbiology and microbial chemotherapy. 2008; (10): 96-112
13. Sun С, Zhou Y, Chai W, Wang Y. Analysis of microbiology and antibiotic susceptibility in 131 cases of prosthetic hip infections. Zhonghua Yi Xue Za Zhi 2014; 94 (21): 1657-1660
14. Lv L, Jiang T, Zhang S, Yu X. Exposure to mutagenic disinfection byproducts leads to increase of antibiotic resistance in Pseudomonas aeruginosa. Environ Sci Technol 2014; 48 (14): 8188-8195
15. Osmon S, Ward S, Fraser VJ, Kollef MH. Hospital mortality for patients with bacteremia due to Staphylococcus aureus or Pseudomonas aeruginosa. Chest 2004; 125 (2): 607-616
16. Goldberg JB, Hancock REW, Parales RE, Loper J, and Cornells P. Pseudomonas 2007. J Bacteriol 2008; 190 (8): 2649-2662
17. Supotnitsky MV. Microorganisms, toxins and epidemics. M.: Higher school text-book, 2010; 376 p.
18. Shimada Т, Matsumura I. Immune evasion of Pseudomonas aeruginosa. Nihon Rinsho Meneki Gakkai Kaishi 2014; 37(1): 33-41
19. Vertiev YuV, Brodinova NS, Moroz AF. Exotoxin A Pseudomonas aeruginosa and its role in the pathogenesis of Pseudomonas aeruginosa infection. Zh Mikrobiol Epidemiol Immunobiol 1981; (2): 13-19
20. Miyazaki S, Matsumoto Т, Tateda К, et al. Role of exotoxin A in inducing severe Pseudomonas aeruginosa infections in mice. J Med Microbiol 1995; 43 (3): 169-175
21. Nikbin VS, Aslani MM, Sharafi Z, et al. Molecular identification and detection of virulence genes among Pseudomonas aeruginosa isolated from different infectious origins. Iran J Microbiol 2012; 4(3): 118-123
22. Woods DE, Cryz SJ, Friedman RL, Iglewski BH. Contribution oftoxinAand elastase to virulence of Pseudomonas aeruginosa in chronic lung infections of rats. Infect Immun. 1982; 36(3): 1223-1228
23. El-Zaim HS, Chopra AK, Peterson JW, et al. Protection against exotoxin A (ETA) and Pseudomonas aeruginosa infection in mice with ETA-specific antipeptide antibodies. Infect Immun 1998; 66 (11): 5551-5554
24. Ezepchuk JuV Pathogenicity as a function of biomolecules. M., 1985; 238 p.
26. Deng Q, Barbieri JT Molecular mechanisms of the cytotoxicity of ADP-ribosylating toxins. Annu Rev Microbiol 2008; 62:271-288). 27. Jger D, Werdan K, Mbller-Werdan U. Endogenous ADP-ribosylation of elongation factor-2 by interleukin-1 p. Mol Cell Biochem 2011; 348 (1-2): 125-128
28. Tafesse FG, Guimaraes CP, Maruyama T, et al. GPR107, a G-protein-coupled Receptor Essential for Intoxication by Pseudomonas aeruginosa Exotoxin A, Localizes to the Golgi and Is Cleaved by Furin. J Biol Chem 2014; 289 (35): 24005-24018
29. Mrsny RJ, Daugherty AL, McKee ML, FitzGerald DJ. Bacterial toxins as tools for mucosal vaccination. Drug Discov Today 2002; 7 (4); 247-258
30. Hansen JK, Forest KT. Type IV pilin structures: insights on shared architecture, fiber assembly, receptor binding and type II secretion. J Mol Microbiol Biotechnol 2006; 11 (3-5): 192-207
31. Jorgensen R, Merrill AR, Andersen GR. The life and death of translation elongation factor 2. Biochem Soc Trans 2006; 34(1): 1-6
32. Davinic M, Carty NL, Colmer-Hamood JA, et al. Role of Vfr in regulating exotoxin A production by Pseudomonas aeruginosa. Microbiology 2009; 155 (7): 2265-2273
33. Chiu CC, Chen HH, Chuang HL, et al. Pseudomonas aeruginosa exotoxin A-induced hepatotoxicity: an animal model in rats. J Vet Med Sci 2009; 71 (1): 1-8
34. Zhao GJ, Hong GL, Liu JQ, et al. Septic shock due to community-acquired Pseudomonas aeruginosa necrotizing fasciitis: A case report and literature review. Exp Ther Med 2014; 7(6): 1545-1548
35. Bard F, Mazelin L, Pechoux-Longin C, et al. Src regulates Golgi structure and KDEL receptor-dependent retrograde transport to the endoplasmic reticulum. J Biol Chem 2003; 278 (47): 46601-46606
36. Borkar DS, Fleiszig SM, Leong C, et al. Association between cytotoxic and invasive Pseudomonas aeruginosa and clinical outcomes in bacterial keratitis. JAMA Ophthalmol 2013; 131 (2): 147-153
37. Somerville G, Mikoryak CA, Reitzer L. Physiological characterization of Pseudomonas aeruginosa during exotoxin A synthesis: glutamate, iron limitation, and aconitase activity. J Bacteriology 1999; 181 (4): 1072-1078
38. Ben Haj Khalifa A, Moissenet D, Vu Thien H, et al. Virulence factors in Pseudomonas aeruginosa: mechanisms and modes of regulation. Ann Biol Clin (Paris) 2011; 69 (4): 393-403
39. Denis-Mize KS, Price BM, Baker NR, et al. Analysis of immunization with DNA encoding Pseudomonas aeruginosa exotoxin A. FEMS Immunol Med Microbiol 2000; 27 (2): 147-154
40. Manafi A, Kohanteb J, Mehrabani D, et al. Active immunization using exotoxin A confers protection against Pseudomonas aeruginosa infection in a mouse burn model. ВМС Microbiol 2009; 9 (23). pubmed/19183501
41. Schumann J, Angermbller S, Bang R, et al. Acute hepatotoxicity of Pseudomonas aeruginosa exotoxin A in mice depends on T cells and TNF. J Immunol 1998; 161 (10): 5745-5754
42. Jenkins CE, Swiatoniowski A, Issekutz AC, Lin TJ. Pseudomonas aeruginosa exotoxin A induces human mast cell apoptosis by a caspase-8 and -3-dependent mechanism. J Biol Chem 2004; 279 (35): 37201-37207
43. Chiu CC, Huang YT, Wang YC, et al. Pretreatment with lipopolysaccharide ameliorates PseudomonasexotoxinA-induced hepatotoxicity in rats. Immunopharmacol Immunotoxicol 2013; 35 (2): 296-303
44. Morrison VV, Morrison AV Qualitative and quantitative changes of cellular composition of peripheral blood in experimental animals effected by Pseudomonas aeruginosa exotoxin. Fundamental research 2008; (4): 19-25
45. Morrison VV, Morrison AV. Immunologic effects of Pseudomonas aeruginosa exotoxin A on white rats. In: Actual problems of medical science and education. Saratov, 2009; p. 178-179
46. Morrison VV, Morrison AV. Immunologic effects of Pseudomonas aeruginosa exotoxin A. In: Actual problems of infectious pathology and vaccine prophylaxis in children. Saratov, 2009; p. 93-94
47. Morrison VV, Morrison AV. The evaluation of protective properties of immunomodulator of diutifon and antioxidant mexidol in Pseudomonas aeruginosa exotoxin. In: Questions on pathogenesis of typical pathological processes. Novosibirsk, 2012; p. 192-194
48. Morrison VV, KudinGB, Nefedova NA. The process of lipid peroxidation and antioxidant system in dynamics of experimental Pseudomonas aeruginosa intoxication. Anesthesiology and Reanimatology 2000; (3): 41-43
49. Morrison VV, Morrison AV. Changes in lipid peroxidation and antioxidant system in dynamics of experimental Pseudomonas aeruginosa intoxication. In: Oxygen and antioxidants. Volgograd, 2009; (1): p. 91-92
50. Morrison VV, Morrison AV Procalcitonin as an indicator of severity of experimental Pseudomonas aeruginosa intoxication. In: Actual problems of pathological physiology. Saratov, 2011; p. 221-224)
51. Sandoval CC, Moreno МС, Abarca VK. Sepsis due to Pseudomonas aeruginosa in a previously healthy infant. Rev Chilena Infectol 2011; 28 (6): 592-596
52. Erol S, Zenciroglu A, Dilli D, et al. Evaluation of nosocomial blood stream infections caused by Pseudomonas species in newborns. Clin Lab 2014; 60 (4): 615-620.

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