Saratov JOURNAL of Medical and Scientific Research

he role of vascular endothelial growth factor in the pathogenesis of lichen planus and psoriasis

Year: 2014, volume 10 Issue: №3 Pages: 539-542
Heading: Skin Diseases Article type: Short message
Authors: Artemina Е.М., Shtoda U.М., Slesarenko N.A., Bakulev A.L., Utz S.R.
Organization: Saratov State Medical University

The goal: to investigate the process of angiogenesis by determining the level of vascular endothelial growth factor (VEGF) in the blood serum of patients with lichen planus (CPL) and psoriasis. Material and Methods. The study included 50 patients with CPL, 62 patients with psoriasis and 36 were in the control group of healthy individuals. All of the participants were to determine the level of VEGF in a blood serum before treatment. Results. Patients with CPL had an increase in the level of VEGF in serum prior to 1992 pg/ml, in the patients with psoriasis — up to 1748.8 pg/ml. Level of VEGF in healthy individuals ranged from 37 to 475 pg/ml. Conclusion. When the CPL and psoriasis excessive angiogenesis is observed, elevated levels of VEGF in the serum of these patients and it is possible that vascular normalization such element of pathogenesis of psoriasis and CPL lead to stable remission of these dermatoses.

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