Saratov JOURNAL of Medical and Scientific Research

Cytokines balance change in gingival fluid at periodontal diseases and its value for the prognosis of regeneration disturbances in periodontal tissues

Year: 2014, volume 10 Issue: №3 Pages: 435-440
Heading: Stomatology Article type: Original article
Authors: Ostrovskaya L.Yu., Zakharova N.B., Mogila А.Р., Katkhanova L.S., Akulova E.V., Popykhova E.B.
Organization: Saratov State Medical University

Purpose: To establish diagnostic value of the increased content of pro- and anti-inflammatory cytokines (IL-8, MCP-1, RAIL) in gingival fluid at patients with a chronic periodontal disease. Material and Methods: 60 patients with inflammatory periodontal diseases were surveyed. The concentration of the studied cytokines in gingival fluid has been defined. Results: At a periodontal disease the increased level of pro- and anti-inflammatory cytokines in gingival fluid has been noted. Conclusion: Definition of the MCP-1 and IL-8 levels in gingival fluid can be used as a criterion of the prognosis of the severity of inflammatory and destructive processes in the periodontal tissues.

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