Saratov JOURNAL of Medical and Scientific Research

Procalcitonin as a diagnostic test for thermal injury

Year: 2014, volume 10 Issue: №1 Pages: 61-64
Heading: Physiology and Pathophysiology Article type: Original article
Authors: Morrison V.V., Bozhedomov A.J.
Organization: Saratov State Medical University
Summary:

Purpose: to determine the diagnostic value of procalcitonin in blood serum with probable development of multiple-organ-failure syndrome in thermal injury. Material and Methods. Procalcitonin test has been performed on the 1st, 3d, 7th, 15th and 30th days after the thermal injury. The expression of systemic inflammatory response syndrome (SIRS), leukocytic intoxication index (Lll) calculated according to Ya.Ya. Kalf-Kalif, levels of C-reactive protein, MCP-1, IL-6, VEGF, endothelin, and a number of circulating endothelial cells have been determined. Results. The increased level of procalcitonin (>0,5 ng/ml) in thermal injury has been observed in 42,7% of recovered patients and in 71,3% of dead patients. Conclusion. It has been found out that procalcitonin test in thermal injury may be used as an early marker for patients liable to develop polyorgan insufficiency syndrome.

Keywords: burns, procalcitonin, SIRS

Bibliography:
1. Bone RC. Toward an epidemiology and natural history of SIRS (systemic inflammatory response syndrome). JAMA 1992; 268 (24): 3452-3455; 2. Reinhart К, Meisner M. Biomarkers in the critically ill patient: procalcitonin. Crit Care Clin 2011; 27 (2): 253-263; 3. Gel'fand BR, Burnevich SZ, Gel'fand EB, et al. Biochemical marker of systemic inflammation: role of procalcitonin in the diagnosis of sepsis. Consilium medicum 2007; (1): 12-20; 4. Morrison VV, Bozhedomov AYu. Significance of procalcitonin concentration in blood plasma in septic state diagnostic. Saratov Journal of Medical Scientific Research 2010; 6 (2): 261-266; 5. Semenova AS, Morrison VV, Dolyshniy VN. Parameters of systemic inflammatory response in early detection and prediction of infectious complications of necrotizing pancreatitis. Saratov Journal of Medical Scientific Research 2007; 3 (3): 106-107; 6. Chan YL, Tseng СР, Tsay РК, et al. Procalcitonin as a marker of bacterial infection in the emergency department: an observational study. Crit Care Med 2004; 8 (1): 12-20; 7. Delevaux I, Andre M, Colombier M. Can procalcitonin measurement help in differentiating between bacterial infection and other kinds of inflammatory processes? Ann Rheum Dis 2003; 62 (4): 337-340; 8. Lekmanov AU, Budkevich LI, Soshkina VV, et al. Procalcitonin and morphological changes in tissues of burn wounds. Infektsii v Khirurgii 2009; 7 (2): 27-32; 9. Petrishchev NN, BerkovichOA, VlasovTD,etal. Diagnostic value of determination of desquamated endothelial cells in the blood. Klinicheskaya i laboratornaya diagnostika 2001; (1): 50-52; 10. Belotskiy SM, Avtalion RR. Inflammation. Mobilization of cellsand clinical effects. Moscow: Binom, 2008; 240 p.; 11. Chesnokova NP, Nevvazhay ТА, Morrison VV, et al. Inflammation: etiology, pathogenesis, pathogeneticsubstantiation therapy. Saratov, 2012; 120 p.

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