Saratov JOURNAL of Medical and Scientific Research

Haemopoiesis and its regulation at various stages of haemopoietic cell differentiation of bone marrow

Year: 2012, volume 8 Issue: №3 Pages: 711-719
Heading: Physiology and Pathophysiology Article type: Review
Authors: Chesnokova N.P., Morrison V.V., Ponukalina Е.V., Zhevak Т.N., Afanasieva G.A., Polutova N.V., Newazhay Т.A.
Organization: Saratov State Medical University

Analysis of literature review has presented authors' opinion about regularities of consistent change of haemopoietic cell differentiation steps in bone marrow. Particular attention has been paid to the role of numerous cytokines (stem cell factor, fit-3ligand, interleukine-3, interleukine-4, interleukine-6, interleukine-7, tumor necrosis factor, colony stimulating factors, erythropoietin, thrombopoietin) in mechanisms of myelo-, erythro- and thrombocytopoiesis in the normal conditions. Results of investigation have showed the important significance of blood cytokine profile disturbances in pathogenesis of tumor progression in chronic lymphocytic leukaemia.

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