Saratov JOURNAL of Medical and Scientific Research

Renal dysfunction and state of metabolic and hemodynamic factors in patients with arterial hypertension

Year: 2011, volume 7 Issue: №4 Pages: 837-842
Heading: Internal Diseases Article type: Original article
Authors: Kurkina T.V., Bogoslovskaya S.I., Svistunov А.А., Kodochigova A.L, Glybochko G.Kh., Klochkov V.A.
Organization: Saratov State Medical University, Saratov Regional Hospital for Veterans of Wars, Saratov Institute of Cardiology, Russia, First Moscow State Medical University n.a. I.M. Sechenov

The aim of the investigation is to carry out comparative evaluation of metabolic and hemodynamic indices in patients with arterial hypertension (AH) and renal dysfunction; to study the interrelation between arterial blood pressure level normalization and the presence or lack of microalbuminuria (MAU) in the morning urine portion of patients with AH after therapy with antihypertensive preparations (APs) of various groups. Methods. 121 persons have been investigated, 91 out — patients of both sexes, aged 33-55, with the diagnosis of arterial hypertension of stage II risk III, who have been taking Perindopril, Telmisartan and Bisoprolol for3 months. The control of arterial pressure level, biochemical analysis of metabolic indices and morning urine portion test for microalbuminuria has been carried out. Results. MAU has been revealed in 17,6% patients, occurring more frequently in men than in women. Microalbuminuria is accompanied by reliable decrease of total and ionized calcium and magnesium concentrations, an increase of potassium level in blood plasma, increase of cholesterol, triglycerides, glucose and levels. Patients with AH and renal dysfunction reliably demonstrate higher levels of systolic and diastolic arterial pressure in the morning and evening hours, their normalization effect after APs intake is significantly interconnected with MAU presence. Conclusion. In patients with AH and MAU the main risk factors of cardio-vascular diseases development are more expressed. Microalbuminuria is a risk factor in patients with arterial hypertension and may influence on the basic blood electrolyte balance. While carrying out antihypertensive therapy the presence of MAU should be taken into consideration

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