Saratov JOURNAL of Medical and Scientific Research

Pathogenic basis and modern prospects in early diagnostics of nephrosclerosis in children with vesicoureteral reflux

Year: 2011, volume 7 Issue: №1 Pages: 151-157
Heading: Urology Article type: Review
Authors: Morozov D.A., Morrison V.V., Morozova O.L., Lakomova D.Y.
Organization: Saratov State Medical University
Summary:

The present article summarizes modern conceptions of tubulointerstitial fibrosis development mechanisms in children with vesicoureteral reflux. The review deals with the questions of extracellular matrix components accumulation and disintegration, tissue hypoxia, remodeling of blood flow, concentration changes in inflammation, sclerosis and angiogenesis biomarkers in the progress of nephrosclerosis

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