Saratov JOURNAL of Medical and Scientific Research

Increased serum homocysteine levels and glutathione-S-transferase activities in alcoholic patients attending de-addiction centre

Year: 2010, volume 6 Issue: №3 Pages: 620-624
Heading: Clinical Laboratory Diagnostics Article type: Original article
Authors: Kulkarni S.R., Ravindra К.Р., Dhume С., Rataboli P.V., Rodrigues E., Rodrigues E.E.
Organization: India, Mumbai-8, Byculla, Grant Medical College & Sir J.J. Group of Hospital, India, Mumbai- 400 098, Kalina, University of Mumbai, India, Goa 403 202, PO. Bambolim Complex, Goa Medical College

The purpose of this study was to investigate the effect of heavy alcohol consumption on serum Malondialdehyde, homocysteine status and glutathione-S -transferase (GST) activities in alcoholics consuming illicit liquor from lower socioeconomic background attending deaddiction centre. The study was conducted in ninety alcoholic patients consuming illicit liquor from lower socio-economic background attending de-addiction centre and compared to healthy non alcoholic controls (n=90). Serum Malondialdehyde (MDA), serum homocysteine and activities of antioxidant enzyme glutathione-S - transferase (GST) were estimated. Alcoholics consuming illicit liquor attending de-addiction centre displayed significantly higher values of serum MDA concentration, serum homocysteine levels and serum GST activities as compared to their non alcoholic healthy controls belonging to the same socio-economic background. Our results indicate that increase in serum Malondialdehyde (MDA) concentration marker of oxidative stress, serum homocysteine levels and serum glutathione-S-transferase (GST) activities may enhance the susceptibility to vascular diseases in heavy illicit drinkers with poor nutritional status

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