№2, 2010, volume 6

The aim of the research is to study pharmacological properties and to determine safety effect diapason, toxico-logical properties of new adenine substances 9-[2-(4-isopropylphenopxy) aethyl] adenine under laboratory code VMA-99-82 which obtains antiviral activity in vitro. the results of the research of neurotoxicologic profile of combination of VMA-99-82 are presented in the work using technique of multistage testing according to «S.lrvin». while performing the research it has been established that safety level of substance VMA-99-82 refers to the class of low toxic combination. the diapason of doses (from 18,7 to 300 mg/kg) of substance evident therapeutic effect has been determined. Side-effects are not expressed significantly. therapeutic effect of the combination VMA-99-82 has behavioral reactions. thus the given substance must be further studied for psychotropic effect and its mechanism action

The purpose of the research is to evaluate the clinical effectiveness of cyclosporine and other antihistamines in patients with chronic forms of urticaria resistant to basic first-line therapy. Open randomized controlled study has been performed in parallel groups. 53 patients with chronic idiopathic urticaria ages 18-50 years have been examined. In case of ineffectiveness of previous therapy, patients have been randomized into 2 groups: group I receiving cyclosporine (Sandimmune Neoral ®) 2,5 mg/kg/day, group II receiving cetirizine (Zyrtec ®) 10 mg/day and ranitidine (Zantac ®) 300 mg/day orally. It has been found that the administration of cyclosporine in patients with severe chronic idiopathic urticaria provides a more rapid achievement of clinical effect than the therapy with H1/H2 histamine antagonists. It is confirmed by a significant decrease of total index of severity of illness and major symptoms of skin lesions. This tendency towards normalization of quality of life of patients taking cyclosporine remains during 8 weeks after the medication. Thus administration of cyclosporine can be considered as therapy of choice in patients with chronic idio-pathic urticaria with a severe course and ineffective long-term therapy with antihistamines / systemic corticosteroids

This article gives an outline of data concerning formation and functioning peculiarities of microbial communities in the form of biofilms. Peculiarities of metabolic processes and virulent properties of bacteria existing in biofilms which are connected to those processes are highlighted in the article. The necessity of taking into account these peculiarities when carrying out antibacterial therapy is also stated

The aim of the investigation was to study the structurae peculiarites of the glands of human trachea at its bifurcation.
The glands of te trachea from 52 people of different age and sex were studied by macro-mocroscopic methods. At the total preparationsof the trachea the multi cellular cells were coloured by R.D. Sinelnikov's method.
The localization of the numerous glands at the cartilaginous and membranaceus walls of the trachea is different. Along the cartilaginous wall of the trachea the glands are arranged in one layer, but at the membranaceus wall- in thre layers. At the cartilaginous wall the initial parts of the glands are located at submucosa and fibrous membrane, at the membranaceus wall- at all layers of the trachea and principal bronchi. At the bifurcation of the trachea the initial parts of the glands from the glandular muff. The compactness of the localization of mouth of the glands is more at the bifurca¬tion of trachea than near this region

In a review results more than 20-years studying age, sexual, constitutional and ethnic laws of morpho-functional variability of the population of Eastern Siberia are presented. Distinctions between groups of the population on overall dimensions, body composition, proportionality of a constitution are shown. The phenomena secular trend, a phenomenon long living people are studied and influence of ecological factors on the physical status of a growing organism is shown

The article was written by the first-year student of Hospital Therapy Department Bulatova Elizaveta. The author deals with her grandfather's memories (Bulatov Victor Mihaylovich was the mortarman of «Katyusha» (M 30) since 1942 till 1945). The history of Leningrad's battle, raising the siege, Europe liberation from Nazis by soldiers of Baltic front told by the event participant are represented in the article. Author's family photo archive is used in the narrative

The presented article gives close attention to feat at the front and at the rear of medical staff of Saratov State Medical Institute