№2, 2010, volume 6

Significance of biological feedback (BFB) therapy in complex treatment of patients with thyrotoxic myocardiodystrophy was analyzed. Evaluation of bioregulation procedures was conducted in 36 patients with diffusive toxic goiter (DTG) and signs of thyrotoxic myocardiodystrophy on the background of drug therapy. Control group consisted of 24 patients with DTG, which took only drug therapy. It was revealed, that combination of drug therapy of DTG with BFB procedures provided significant influence on state of vegetative nervous system, and it also led to quick decrease of clinical symptoms of thyrotoxic myocardiodystrophy, in contrast to isolated drug therapy

The research goal is to evaluate the impact of autonomic heart control indices on five-year risk of lethal outcome and development of cardiovascular disorders in patients with acute myocardial infarction (AMI) and to study the dynam¬ics of indices in short- and long-term period. 125 patients with AMI (42% female), ages 30 to 83 years, were enrolled in prospective observational study. Observation period lasted 6 years. Control checking was carried out in 1 week, 3 weeks, 6 months, 1 year and then annually. The dynamics of heart rate variability (HRV) and the synchronization of 0.1-Hz rhythms of heart and microcirculation (S) were studied during the first year. Outcomes proved to be death, MI, stroke. Development of acute heart failure Killip 2-4 and indices S < 20% during the first week of AMI (х2 = 10,5, p = 0,005 for the Cox model) played a significant role in evaluation of five-year risk of death after AMI. Sensitivity (Se) and specificity (Sp) of index S < 20% during the first week of AMI were 76% and 43% correspondingly. The Cox model showed that indices of HRV and 0.1-Hz rhythms synchronization were not of great value in evaluation of five-year risk of death after AMI. The article concludes that indices S < 20% in patients with AMI possess better prognostic value than common clinical parameters

The scientific work is devoted to examination of 180 patients with arterial hypertension in case of metabolic syndrome during the period of 12 months. By the end of initial examination patients were divided into 3 groups. The first group (72 men and women) was regularly checked by cardiologist once in 3 months, the second one (60 patients) -once in 6 months, the third group (48 patients) was observed once a year. Accordingly regular clinical examination provides more effective conditions for observation and treatment, improvement of health state and hemodynamic indices allowing to cosider the given way of clinical examination as a rational and effective method

The research goal in to determine clinical and pathogenetic efficacy of Cycloferon liniment in the combined therapy of parodontitis in patients with chronic hepatitis C. Examination and treatment of 50 patients were conducted. It was revealed that the use of Cycloferon liniment in the combined treatment of patients with parodontitis accompanied by chronic hepatitis C allowed to accelerate process of normalization of lipid peroxidation and antioxidant potential of blood, to decrease infectious inflammation (herpes simplex virus I, candida albicans, staphylococcus aureus) in parodontal recess and local inflammation. The described method of treatment provided process of recovery and decrease in frequency of parodontitis recurrences

The review of recent data is presented in the article. it concerns pathogenesis, course, progressing of pathologic process in liver, methods of treatment of patients with alcoholic liver disease

The research goal was to investigate cytokine profile (IL-1p, 11_-1ра, IL-4, IL-6, IL-8, TNF-a and INF-у) in patients with chronic obstructive pulmonary disease (OOPD). The data of decreasing of anti-inflammatory IL-4 and increasing of proinflammatory cytokines in patients with OOPD were worked out. Inclusion of domestic immunomodulator of immunovenin in standard therapy of OOPD permitted to decrease concentration of proinflammatory cytokines and to increase the level of anti-inflammatory IL-4

At adult rats are caused experimental toxic liver injury of the various severity by introduction of carbon tetrachloride in a doze of 0.25 ml and 0.5 ml on 100 g of weights. It is investigated the functional condition of the liver with use glucose tolerance test (GTT) and galactose tolerance test (СаlТТ). It is revealed, the most informative for the investigation of liver function was the end of the first hour from beginning GPr and GаlТТ. Use of the coefficient, reflecting a correlation of glucose concentration in blood at the end of the first hour of ГТТ and Га!ТТ, makes it possible to raise diagnostic value of tolerance tests

It has been established during the experiments carried on noninbred rats that chronic intoxication of ethanol (30 days, total dose - 6,0 LD50) essentially reduces concentration of cytokines (IFNy, IL-2, IL-4, IL-6,IL-10) in blood, reduces interrelation of IFNy/IL-4 in comparison with the control, suppresses immune reactions, indicating the greater lesion of Th1-cells in comparison with Th2-lymphocytes

The article presents data about high frequency of polyhypovitaminosis (72,6%), reduced level of microelements in blood (in 19,4-45,2% of cases), insufficient consumption of iodine and calcium (in 95,2% of cases) in pregnant women of Saratov Region. It was determined, that micronutrients deficiency in mothers in 1,55-5,48 times exceeds relative risk of pathologic pregnancy course, delivery, disorders of adaptation and morbidity of newborns. It was revealed, that prophylactic intake of vitaminous mineral medications results in absolute risk reduction of pregnancy and delivery, disorders of fetus state and newborns health in 13-54%

Research goal. To study peculiarities of psychovegetative status of pregnant women with fetoplacental insufficiency in condition of delivery preparation by means of biologically feedback method.
Materials and methods. 56 pregnant women with chronic fetoplacental insufficiency took drug therapy along with biologically feedback method (BFM), 24 patients didn't undergo seances of bioregulation. Therapeutic results were evaluated after 2-4 weeks of BFM.
Results. Probability of chronic fetoplacental insufficiency progress in the absence of BFM-therapy was 32,8%; after seances of bioregulation - 11,3%. Use of BFM-therapy for women with chronic fetoplacental insufficiency promotes normalization of psychovegetative status and decreases probability of this pathology progress by 21,5%.
Conclusion. BFM-therapy had maximum efficacy in its day-time conduct. After day-time seances 71,2% of positive results was revealed; in evening - 44,6%; in morning - 56,3%. In day-time BFM-therapy seances 11,6% of unsatisfactory results was marked; while morning and evening seances recognized 18,9% and 23,4% accordingly