Saratov JOURNAL of Medical and Scientific Research

Gorin D.A.

Skolkovo Institute of Science and Technology, Center of Photonics and Quantum Materials, Professor, Doctor of Chemical Sciences

Peculiarities of microcirculatory reactions after subcutaneous implantation of polycaprolactone matrices mineralized by vaterite

Year: 2018, volume 14 Issue: №1 Pages: 35-41
Heading: Physiology and Pathophysiology Article type: Original article
Authors: Norkin I.A., Ivanov A.N., Kurtukova M.O., Savelyeva M.S., Martyukova A.V., Gorin D.A., Parakhonsky B.V.
Organization: Saratov State Medical University, Saratov state university, Skolkovo Institute of Science and Technology
Summary:

The aim is to assess skin microcirculation changes arising during subcutaneous implantation of polycaprolactone scaffolds mineralized by vaterite. Material and Methods. The experiment was carried out on 30 albino rats divided into two groups: a negative control group and an experimental one. We implanted polycaprolactone scaffold with exhausted foreign protein subcutaneously into rats of the negative control group. We implanted polycaprolactone matrix mineralized by vaterite subcutaneously into the animals of the experimental group. Research methods include laser Doppler flowmetry and morphological examination of the tissues of the matrix implantation area. Results. Changes of skin microcirculation over the matrix allocation area correspond to the morphological pattern of tissue reactions. Biocompat-ibility disorders take the form of inflammation in the scaffold implantation area that is accompanied by stable perfusion rise associated with local bloodstream modulation changes. We did not observe inflammation signs in the surrounding scaffold tissues during implantation of polycaprolactone matrices mineralized by vaterite. Besides local microcircula-tory reactions possess a transient character disappearing completely by the 21st day after the implantation. Conclusion. Complex of the given functional and morphological studies allow us to ascertain high-grade biocompatibility of polycaprolactone matrices mineralized by vaterite thus giving rise to prospect of their use for tissue regeneration stimulation.

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Surface modification of orthodontic implants by nanocomposite coatings based on chitosan and metals

Year: 2013, volume 9 Issue: №3 Pages: 472-477
Heading: Stomatology Article type: Original article
Authors: Suetenkov D.Ye., Gorin D.A., Portnov S.A., Karagaychev A.L., Terentyuk G.S., Zakharevich A.M., Khlebtsov B.N., Firsova I.V.
Organization: Saratov State Medical University, Saratov state university, Институт биохимии и физиологии растений и микроорганизмов РАН
Summary:

Purpose: to study the properties of nanostructured coatings in orthodontic implants. Material and methods. Low and average molecular mass chitosan, 3-amynopropil-3-methoxysylan and suspensions of 5 nm and 10 nm gold nano-spheres stabilized with natrium citrate were used for nanocomposed surfaces. 2mg/ml polyethylenamin water solution was used for making the underlayer before putting polyion coverage using «POLYION-1M». The polyion covering dynamics was studied by polyquartz weighing method. Morphology of created layers was studied with atomic microscopy, elements were studied by secondary ion mass-spectrometry. Results. The best transmission among structures of chito-san/metals was showed by low molecular mass of chitosan and 8-1 Onm nanoparticles of metals. Analysis of roughness of surface shows that nanoparticles of gold make the most solid surface on 3-amynopropil-3-methoxysylan underlayer. Conclusion. The development of biocomparative materials in maxillofacial surgery is considered to be effective method of decreasing the risk of post-operative inflammatory complications by local antibacterial effect.

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