Saratov JOURNAL of Medical and Scientific Research

advanced age

Age and age-dependent predictors for the risk assessment in elderly and senile patients with chronic heart failure

Year: 2020, volume 16 Issue: №1 Pages: 172-176
Heading: Тhematic supplement Article type: Original article
Authors: Malinova L.I., Lipatova Т.Е., Zhuk A.A., Dolotovskaya P.V., Furman N.V., Denisova T.P.
Organization: Saratov State Medical University

Objective: to assess the presence and nature of age-dependent changes in the predictors used for risk stratification of patients with chronic heart failure (CHF). Material and Methods. We perform an analysis of predictive models of CHF, including a comparative assessment of predictors and age of patients. At the second stage, age-dependent changes in the most commonly predictors of CHF were characterized. The study included hospitalized patients with CHF (36-94 years, n=2764). Results. We analyzed 275 prognostic models based on results of large studies (n=36062±5814). The mean age of the patients involved was 68.9±7.6 years. The major predictors included the patient's age and/or potentially age-dependent parameters: hemoglobin, creatinine, RDW, LVEF, SBP and NT-proBNP. In the study sample all of these parameters correlated with the age of the patients with the maximum correlation strength of "NT-proBNP — age" (R=0.57; p<0.05) and "hemoglobin level — age" (-0.57; p<0.05). Conclusion. The prevalence of mature and elderly patients in the populations of studies used to develop the majority of risk instruments for heart failure is revealed. The age-dependent nature of the predictors used in the risk of heart failure is established (hemoglobin, creatinine, RDW, LVEF, SBP and NT-proBNP). The simultaneous use of age and age-dependent parameters as predictors when creating risk-assessment tools may be considered as one of the reasons for the unsatisfactory quality of risk stratification in CHF, including elderly and senile patients.

2020-01-1_172-176.pdf389.36 KB

Chronic atrophic gastritis in patients over 60 years of age: clinical, morphofunctional, and neuroendocrine parameters

Year: 2020, volume 16 Issue: №1 Pages: 160-163
Heading: Тhematic supplement Article type: Original article
Authors: Lipatova Т.Е., Islamova Е.А., Tyultyaeva L.A., Khaybekova T.V., Vakhlyueva O.G.
Organization: Regional Hospital for War Veterans, Saratov, Saratov State Medical University

Objective: to analyze the clinical, morphological and neuroendocrine parameters of the course of chronic H. pylori-associated atrophic gastritis in patients 60 years of age and older in comparison with similar parameters in patients younger than 60 years with chronic H. pylori-associated non-atrophic gastritis. Material and Methods. 60 patients with chronic atrophic H. pylori-associated gastritis and 20 healthy individuals were examined. Clinical symptoms of the disease, H. pylori seeding rate, esophagogastroduodenoscopy, morphological and immunohistochemical analysis were evaluated. Results. Patients older than 60 years are less likely than patients younger than 60 to have epigastric pain and heartburn pain, but more often dyspeptic syndrome, but the degree of gastritis activity and the degree of contamination of H. pylori was lower. There are more NO synthase-immunopositive cells, and less immunotropic motilin cells than in patients under 60 years of age. Conclusion. Patients older than 60 years have specific features of the formation of chronic H. pylori-associated atrophic gastritis.

2020-01-1_160-163.pdf476.94 KB

Morphometric parameters of cerebral arteries in the elderly

Year: 2019, volume 15 Issue: №1 Pages: 94-97
Heading: Human anatomy Article type: Original article
Authors: Fomkina О.А., Gladilin Yu.A.
Organization: Saratov State Medical University

Objective: to identify the features of morphometric parameters of cerebral arteries in adults aged 55-74 years. Material and Methods. As a material of the study we used samples of anterior (АСА), middle (MCA), posterior cerebral (PCA), posterior connective (PCoA), basilar arteries (BA) and vertebral arteries (VA), seized at autopsy 21 corpses of adults who died in old age. External diameter, wall thickness and length of arteries were studied by morphometry. The lumen diameter was calculated as the difference between the outer diameter and the doubled wall thickness. The material was processed by variational-statistical method. Results. The article presents the average values and parameters of variability of the main morphometric parameters of arteries supplying the brain. The results of the comparative analysis with the average values typical for adults aged 21-90 years are presented. Conclusion. The length, wall thickness, outer diameter and lumen diameter of the cerebral arteries in adults 55-74 years are characterized by significant variability. In the studied age range, АСА and PCA are characterized by the same wall thickness; MCA and VAare the same wall thickness, outer diameter and lumen diameter. The wall thickness of BA and VA in the elderly is 28.1 and 17.9% higher than the average value typical for people 21-90 years.

2019_1_094-097.pdf626.01 KB

Strategy and tactics of surgical treatment in elderly patients with ischemic form of diabetic foot syndrome

Year: 2015, volume 11 Issue: №1 Pages: 049-052
Heading: Gerontology and geriatrics Article type: Review
Authors: Shapkin Yu.G., Yuanov A.A., Efimov E.V.
Organization: Saratov State Medical University, Regional Hospital for War Veterans, Saratov

The article analyzes the Russian and foreign publications on the issue of treatment of elderly and senile patients with critical limb ischemia and diabetes mellitus. It is shown that the topic is relevant, and, despite its wide coverage in the press, does not have the final decision. Currently unresolved issues include the terms and indications for reconstructive surgery, the amount and the method of amputation, postoperative care.

2015_01_046-052.pdf376.49 KB

Postural violations in elderly people according to computer stabilometry

Year: 2013, volume 9 Issue: №2 Pages: 291-294
Heading: Neurology Article type:
Authors: Ziteva О.О., Poverennova I.E.
Organization: Samara State Medical University

Postural violations (PV) compose the topical issue for elderly people. The research objective is to study features of postural control at elderly people by means of the computer stabilometry (CS). This technique can also serve as control of efficiency of the carried out therapy of PN. In literature there are only single researches devoted to the change of the main rack for persons over 60 years. Material and Methods: 138 patients aged from 61 to 102 years have been investigated and averaged 77,8+2,3 years. Three age groups of the persons under the study by 46 years have been determined: elderly, old men and long-livers. Results proved the expressed decrease in compensatory opportunities of maintenance of balance at people after 60 years, growth of postural instability according to the increase in age. Prior to therapy at all patients significant increase in the area and length of statokineziograms, speed of movement of the center of pressure has been revealed; average value of the «average position of the center of pressure» parameter in the frontal and sagittal planes considerably differed from normal indicators. After carrying out a standard course of treatment average values of the Deviation, Way and Speed parameters decreased in comparison with similar values before the treatment. Average value of the area parameter appeared to be the most sensitive to medical influences. Conclusion: The CS method allows to carry out rather objectively early diagnostics of PN at elderly people and to estimate their condition in dynamics.

2013-02_291-294.pdf255.79 KB