Saratov JOURNAL of Medical and Scientific Research

Lepilin A.V.

Saratov State Medical University n.a. V. I. Razumovsky, Head of Department of Dental and Maxillofacial Surgery, Professor, Doctor of Medical Science

Features of dental prosthetics at patients with chronic periodontitis and coronary heart disease

Year: 2019, volume 15 Issue: №2 Pages: 251-256
Heading: Stomatology Article type: Original article
Authors: Lepilin A.V., Eremin A.V., Lipatova T.E.
Organization: I.M. Sechenov First Moscow State Medical University, Saratov State Medical University
Summary:

Objective: at patients with chronic generalized periodontitis in combination with chronic ischemic heart disease to study the change of cytokines, biomarkers of osteoproliferation and osteoresorption in comparison with the character- istics of endothelial functions and the determine rational approaches to prosthetics. Material and Methods. 90 patients with periodontitis and coronary heart disease, who use metal, metal-ceramic and removable partial dentures using thermoplastic resin were survey. We studied of cytokines, markers of bone metabolism in the oral fuid, evaluated va-sodilating, vasoconstrictor and adhesive endothelial function. Results. The coronary heart disease in combination with chronic periodontitis is characterized by the endothelial dysfunction, which associated with the activity of periodontitis. Biochemical manifestations of periodontitis, bone resorption and endothelial dysfunction are more pronounced by the use patients metal dentures compared to metal-ceramic and removable partial dentures using thermoplastic resin. Conclusion. The use of patients at periodontitis and coronary heart disease metal dentures, in contrast to patients using metal-ceramic and removable partial dentures using thermoplastic resin, is accompanied the increase of biochemical markers of infammation and bone resorption in the oral fuid and the endothelial dysfunction.

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Features of dental prosthetics at patients with chronic periodontitis and coronary heart disease

Year: 2019, volume 15 Issue: №2 Pages: 251-256
Heading: Stomatology Article type: Original article
Authors: Lepilin A.V., Eremin A.V., Lipatova T.E.
Organization: I.M. Sechenov First Moscow State Medical University, Saratov State Medical University
Summary:

Objective: at patients with chronic generalized periodontitis in combination with chronic ischemic heart disease to study the change of cytokines, biomarkers of osteoproliferation and osteoresorption in comparison with the character- istics of endothelial functions and the determine rational approaches to prosthetics. Material and Methods. 90 patients with periodontitis and coronary heart disease, who use metal, metal-ceramic and removable partial dentures using thermoplastic resin were survey. We studied of cytokines, markers of bone metabolism in the oral fuid, evaluated va-sodilating, vasoconstrictor and adhesive endothelial function. Results. The coronary heart disease in combination with chronic periodontitis is characterized by the endothelial dysfunction, which associated with the activity of periodontitis. Biochemical manifestations of periodontitis, bone resorption and endothelial dysfunction are more pronounced by the use patients metal dentures compared to metal-ceramic and removable partial dentures using thermoplastic resin. Conclusion. The use of patients at periodontitis and coronary heart disease metal dentures, in contrast to patients using metal-ceramic and removable partial dentures using thermoplastic resin, is accompanied the increase of biochemical markers of infammation and bone resorption in the oral fuid and the endothelial dysfunction.

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Periodontal disease at cardiovascular pathology

Year: 2019, volume 15 Issue: №2 Pages: 246-251
Heading: Stomatology Article type: Review
Authors: Eremin A.V., Lepilin A.V., Lipatova T.E.
Organization: First Moscow State Medical University n.a. I.M. Sechenov, Saratov State Medical University
Summary:

The purpose of the systematic literature review was to characterize existing problem of the relationship between cardiovascular diseases and periodontal diseases on the basis of information analysis of the Russian and English original studies and metanalyses published in open access bibliographical databases such as eLibrary and PubMed the past ten years as a methodological basis for future clinical and experimental studies

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The value of composition and cytokine activity of wound discharge cells in patients with acute odontogenic inflammatory diseases of the maxillofacial region

Year: 2015, volume 11 Issue: №2 Pages: 173-177
Heading: Stomatology Article type: Original article
Authors: Lepilin A.V., Zakharova N.B., Fedotenkova D.A., Tereshkina N.E.
Organization: Saratov State Medical University
Summary:

Purpose: to establish the diagnostic value of the immune cells composition and cytokine activity of the cells in wound discharge from patients with acute odontogenic inflammatory diseases of maxillofacial region. Materials and methods. A total of 31 patients with acute odontogenic inflammatory diseases of maxillofacial region were examined. The number of immune cells and pro-inflammatory cytokines content (IL1(3, MCP1, IL6, IL8, TNFa) in the wound discharge were determined. Results. It has been established that depending on the severity of the inflammatory process in maxillofacial region the immune cells composition and levels of pro-inflammatory cytokines are changing. Conclusion. Determination of the immune cells composition and level of cytokines in the wound discharge can be used for estimation of the character and severity of acute odontogenic inflammatory processes in the maxillofacial region.

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The use of professional oral hygiene in orthodontic treatment on the results of studies of gingival fluid biomarkers

Year: 2015, volume 11 Issue: №2 Pages: 168-173
Heading: Stomatology Article type: Original article
Authors: Zakharova N.B., Lepilin A.V., Vorobjev D.V., Erokina N.L., Bakhteeva G.R.
Organization: Medical Clinic "Medstom", Saratov State Medical University
Summary:

The aim: to prove the necessity of professional oral hygiene before the fixation of permanent orthodontic equipment in individuals with dental and facial anomalies based on the study of biomarkers of gingival fluid. Materials and Methods: Clinical, cytological examination and gingival fluid test on cytokine levels in 80 patients. Results: In patients with dentofacial anomalies observed decline in hygiene index, and increase the content of gingival fluid neutrophils and degenerative epithelial cells. It is accompanied by an increase in the concentration of the main group of pro-inflammatory and osteogenic cytokines, growth factors. Conclusion: Preliminary conducting professional oral hygiene to orthodontic treatment in patients with dentofacial anomalies leads to the conservation values of satisfactory hygienic indices of the mouth. In this case, the increase in the content of gingival fluid neutrophils and degenerative epithelial cells, with increased concentrations of the main group of pro-inflammatory and osteogenic cytokines has been defined insignificant.

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Modern technologies of local injection anesthesia in dental practice

Year: 2013, volume 9 Issue: №3 Pages: 470-472
Heading: Stomatology Article type: Original article
Authors: Sohov S.Т., Bizyev, A.F., Lepilin A.V.
Organization: Moscow State Medical Stomatological University n.a. A. I. Evdokimov, Saratov State Medical University
Summary:

Objective: To assess the importance of using the new system Quick Sleeper for local anesthesia, to highlight benefits of quick and comfortable anesthesia. Material and Methods. The examination of effectiveness, convenience of this kind of anesthesia has been carried out. Results. All patients, taking part in this examination, confirmed more comfortable condition after this anesthesia than conductor and infiltration methods of anesthesia. The effect of anesthesia is better than after conductor anesthesia. Conclusion. This technology guarantees equal introduction and spread of anesthetic, independently of tissue density, eliminating the risk of carpule breakage.

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Scientific fundamentals for the development of dental implants

Year: 2013, volume 9 Issue: №3 Pages: 431-434
Heading: Stomatology Article type: Author's opinion
Authors: Lyasnikov V.N., Lepilin A.V., Protasova N.V.
Organization: Saratov State Technical University, Saratov State Medical University
Summary:

The article deals with topical issues of development, production and application of modern biocompatible materials and coatings based on them to clinical practice. Particular attention is paid to the intraosseous dental implants, which considered to be the most popular and well established methods to address the defects of dentition with partial and fully edentulous state.

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Clinical and statistical analysis of traumatic injuries of the maxillofacial region and its complications on materials of the Department of Maxillofacial Surgery from 2008 till 2012

Year: 2013, volume 9 Issue: №3 Pages: 425-428
Heading: Stomatology Article type: Original article
Authors: Lepilin A.V. Bakhteeva G.R., Nozdrachyov V.G., Shikhov M.Y., Ramazanov A.Kh.
Organization: Clinical Hospital № 9, Saratov, Saratov State Medical University
Summary:

Purpose: to study the frequency of occurrence of various traumatic injuries of the maxillofacial region. Material and Methods. The records of patients who were treated in the maxillofacial department, in the period from 2008 to 2012 were studied. Results. The number of patients with traumatic injuries of the maxillofacial region forthe period amounted to 38% of the total number of hospitalized patients. The average age of patients with maxillofacial trauma is 27.5 years.
The ratio of male and female patients during the study period did not change (men 89%, women — 11 %). Single fractures that do not require surgical treatment were dominated. Operating activities during the study period of fracture increased. For 5 years, the number of complications of traumatic injuries remained the same. Conclusion. Statistical analysis of traumatic injuries of the maxillofacial region shows that the average age of the patients decreased by almost 5 years, reduced average hospital stay. Most of the patients were admitted to the profile department in the early period (up to 3 days after preparation), but 21.6% of the patients were received only with the development of complications. The article concludes that there is a need to find new methods of diagnosis, treatment and prevention of complications of traumatic injuries.

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The possibility of different CAD systems in the construction of mathematical model of bone tissue

Year: 2013, volume 9 Issue: №3 Pages: 403-405
Heading: Stomatology Article type: Author's opinion
Authors: Ivanov D.V., Lepilin A.V., Smirnov D.A., Dol A.V.
Organization: Saratov State Medical University, Saratov state university
Summary:

Modern methods of diagnosing of maxillary bones in various clinical situations presume a method of computer tomography. In some cases, the treatment planning according to three-dimensional image cannot be performed and the question of creation of the biomechanical model study area arises. Various methods of computer-aided design and three-dimensional modeling are worth while using to achieve the realization of the task.

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Urgent problems of improvement of stomatologic aid to patients with locally extended cancer of oral cavity mucus

Year: 2013, volume 9 Issue: №3 Pages: 397-399
Heading: Stomatology Article type: Original article
Authors: Ivanova О.V., Maty akin G.G., Lepilin A.V.
Organization: Saratov State Medical University, Central Clinical Hospital, Moscow, Astrakhan Stomatologic Polyclinic №4
Summary:

Aim of the investigation: to develop the methods of increasing effectiveness of stomatologic accompanying therapy at all stages of locally extended cancer of oral cavity mucus. Material and methods: The results of treatment of 563 patients with locally extended cancer of oral cavity mucus have been analyzed. Among them 205 patients with the proved diagnosis were examined by a dentist. A special committee developed a plan of accompanying therapy where a stomatologic treatment was significant. Other 358 patients were not examined by a dentist before therapy. Re-sults. Planning of stomatologic aid and carrying out measures directed to the prevention of complications against the background of combined and complex therapy of locally extended cancer of oral cavity mucus allows to decrease the number of hemorrhagic complications to 4,9%, local inflammatory processes — to 2,7% as well as other complications. Conclusion: Planning of accompanying stoma-tologic therapy and organization of adequate curable and rehabilitation measures significantly improves life quality of the patients with locally extended cancer of oral cavity mucus.

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