Saratov JOURNAL of Medical and Scientific Research

Novosibirsk State University

Progression of chronic heart failure in atrial fibrillation in patients with arterial hypertension in combination with extracardial pathology


Purpose: to study the features of the course of atrial fibrillation (AF) in patients with arterial hypertension (AH) and chronic heart failure (CHF) in combination with concomitant extracardial pathology and to assess the effect of AF on the progression of chronic heart failure. Material and Methods. In an observational cohort study was observed in 308 patients 45-60 years with AF in hypertension and CHF in combination with noncardiac pathology: diabetes mel-litus (DM) (n=40); diffuse toxic goiter (DTG) (n=42); hypothyroidism (GT) (n=59); abdominal obesity (АО) (n=64); and chronic obstructive pulmonary disease (COPD) (n=47). The comparison group consisted of 56 patients with AF and CHF hypertension, without concomitant noncardiac disease. When comparing groups, the unpaired Mann — Whitney U- test for numerical variables and the exact two-way Fisher test for categorical variables were used. Differences were considered significant at a level of p <0.05. The calculations were carried out in the program Rstudio. Results. In all the presented clinical groups there were no differences in the frequency of the permanent form of AF, paroxysmal form was more often recorded in thyroid and АО pathology, and persistent form in COPD, DTZ and DM. Transformation of paroxysmal AF into chronic AF occurred in groups of patients with DTZ (p<0.001), DM (p=0.041) and АО (p=0.004). Progression of CHF was revealed in groups of patients with DTZ (p<0.004), DM (p<0.008), АО (p<0.001) and COPD (p=0.05). Conclusion. Significant progression of AF and CHF is observed in patients with SSD, COPD, АО and DTZ. The most pronounced indicators of left ventricular diastolic dysfunction were found in patients with DM, GT and АО.

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Clinical dermatoscopy of big melanocytic naevuses in patients with psoriasis

Year: 2012, volume 8 Issue: №2 Pages: 646-650
Heading: Skin Diseases Article type: Original article
Authors: Sergeyeva I.G., Krinitsyna J.M., Onipchenko V.V., Makarova N.G.
Organization: Novosibirsk State University

The study aimed to determine clinical characteristics of dermatoscopy of big melanocytic naevuses (MN) in patients with psoriasis. Methods. The were 32 patients with psoriasis (11 women at an average age of 37,4 years) and 100 people (79 women at an average age of 27,8 years) with no psoriasis. Both groups had a survey and full photometry screening of skin. Besides Fitzpatrick skin typing test was used, pigmentary formations were examined using dermato-scope HEINE MINI 3000 10X with 70 % ethyl alcohol immersion. Naevuses were estimated by ABCD and ABC scales. Results. MN more than 5 mm in diameter are more often in patients with psoriasis (68,8 %) than in control group (37 %). However in control group there are less naevuses of appropriate dermatological dysplastic formations criteria (32 %) comparison to the group without psoriasis (42 %). There is an important fact that patients with psoriasis often have 2-phototype of skin and artifcial insolation (tanning bed, PUVA, narrow-band phototherapy 311 nm. Conclusion. 68,8 % patients have MN more than 5 mm in diameter. 32 % of patients with psoriasis had MN of dysplastic naevus criteria according to Pehamberger. In one patient naevus was of appropriate malignant tumors criteria according to ABCD and ABC scales.

Keywords: psoriasis
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