Saratov JOURNAL of Medical and Scientific Research

Morrison A.V.

Saratov State Medical University n.a. V. I. Razumovsky, Department of Skin and Venereal Diseases, Candidate of Medical Science

Contribution of Saratov school of dermatology to the study of rare and chronic dermatoses in the 20-30s of the XX century

Year: 2019, volume 15 Issue: №1 Pages: 136-140
Heading: Scientific schools and memorable dates Article type: Short message
Authors: Yakupov IA, Zavyalov Al, Utz SR, Morrison AV, Mizinov DS, Kryukov YuYu.
Organization: Moscow Scientific and Practical Center of Dermatology, Venereology and Cosmetology of Moscow City Health Department, Saratov State Medical University
Summary:

The article is devoted to the scientific and practical contribution of the staff of the clinic of skin and venereal diseases of the Saratov Medical Institute in the study of etiology, pathogenesisand development of modern methods of diagnosis and treatment of rare and chronic skin diseases in the first half of the twentieth century.

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Clinical case of a very rare form of keratodermia in a child

Year: 2018, volume 14 Issue: №4 Pages: 763-765
Heading: Dermatovenerology Article type: Case report
Authors: Slesarenko N.A., Morrison A.V., Marchenko V.M., Moiseev A.A., Ulanova A.M., Dobdina A.Yu.
Organization: Saratov State Medical University
Summary:

 Cases of keratoderma are the most common among genodermatoses and take the second place after a group of ichthyosis. The frequency of occurrence of keratodermia in the world, including Russia, is from 1:300 to 1:15000. There is a very rare form of diffuse keratoderma: Olmsted Syndrome, which in 2009 is described in 10 sources of scientific literature. The defeat not only affects the palms and soles, and skin around the orifices, forms a flexion deformity and con-tracture fingers, until spontaneous amputation. Some observations noted the presence of follicular keratosis of the extremities, leukokeratosis on the face and language, pererastayut joints, alopecia, absence of premolars. We present a clinical case of a patient with this pathology.

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Neurofibromatosis in the practice of dermatology

Year: 2018, volume 14 Issue: №4 Pages: 760-763
Heading: Dermatovenerology Article type: Case report
Authors: Slesarenko N.A., Morrison A.V., Marchenko V.M., Moiseev A.A., Sherstobitova K.Yu., Ishmukhametova R.A.
Organization: Saratov State Medical University
Summary:

Neurofibromatosis belongs to the group of systemic hereditary diseases from the group of phakomatosis, characterized by developmental defects of ectodermal and mesodermal structures, mainly of the skin, nervous and bone systems, with an increased risk of developing malignant tumors. There are 7 types of the disease include a wide range of clinical manifestations even within the same family: a progressive course, the involvement of almost all organs and systems in the process, a high risk of complications, including many serious and fatal (cardiovascular) pulmonary insufficiency due to severe skeletal abnormalities, malignant degeneration by neurofibromas, etc.). An analysis of 5 clinical cases with neurofibromatosis is presented.

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The effect of botulinum toxin type A injections on production of sebum in seborrhea

Year: 2018, volume 14 Issue: №4 Pages: 740-744
Heading: Dermatovenerology Article type: Original article
Authors: Kondrateva А.А., Galkina Е.М., Karakaeva A.V., Morrison A.V., Morrison V.V.
Organization: Saratov State Medical University
Summary:

 Aim: assessment of sebum production dynamics in patients who received treatment for mimic and static wrinkles in glabella and forehead regions with phase of a menstrual cycle taken into account. Material and Methods. We observed 15 female patients aged 24-38 years who received botulinum toxin therapy. Each BTX-Avial contained 100 units of lyophilized preparation. The solution of BTX-Awas prepared by mixing it with 2 ml of sterile saline. Five intramuscular injections with 2 U of BTX-A per point were made across the forehead, while 3 U injections were done in the glabellar area. The total amount of botulinum toxin used was 19 U per patient. Results. Maximum decrease in sebum production was observed 4 weeks after botulinum toxin injections, and return to baseline was observed at 16 weeks of follow-up. Conclusion. According to the obtained data, it may be stated that botulinum toxin injections affect sebum production with a maximum decrease observed at 4 weeks after botulinum toxin therapy.

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Transfollicular drug delivery: current status of the problem

Year: 2018, volume 14 Issue: №4 Pages: 735-737
Heading: Dermatovenerology Article type: Review
Authors: Talnikova Е.Е., Svenskaya Yu.l., Dobdina A.Yu., Morrison A.V., /UtzS.R./
Organization: Saratov State Medical University
Summary:

The review is dedicated to one of the promising areas in medicine —transfollicular drug delivery. The article presents
literature data on working principles of this route of administration, main practical aspects and future prospects for its
use.

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A clinical case of Stevens-Johnson syndrome in a patient with pustular psoriasis

Year: 2017, volume 13 Issue: №3 Pages: 646-648
Heading: Dermatovenerology Article type: Original article
Authors: Utz S.R., Bakulev A.L., Morrison A.V., Igonina I.A., Ardalina O.O.
Organization: Saratov State Medical University
Summary:

Saratov Journal of Medical Scientific Research 2017; 13 (3): 646-648. The article presents a clinical case of Stevens — Johnson syndrome and generalized pustular patient with HIV-infection. The characteristic of anamnestic, clinical, laboratory data is present. The cause of acute allergic reactions and the formation of severe dermatosis in a patient with HIV-infection are considered.

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Exotoxin A Pseudomonas aeruginosa influence on working efficiency of white rats

Year: 2017, volume 13 Issue: №3 Pages: 472-474
Heading: Physiology and Pathophysiology Article type: Original article
Authors: Morrison V.V., Popovich V.I., Vasyutina V.O., Morrison A.V.
Organization: Central Scientific Research Experimental Institute 33, Saratov State Medical University
Summary:

Objective: to study exotoxin A Pseudomonas aeruginosa influence on physical and mental efficiency of white rats. Material and Methods. The experiments were carried out on white rats following intraperitoneal injections of exotoxin A Pseudomonas of different doses (0.1,0.5 and 1.0 LD50). Physical and mental efficiency of white rats was determined by the scheme of "Machfs camera". Results. Introducing exotoxin A Pseudomonas of 1 LD50 there was conditioned response damage in 20% of animals. The amount of cases of physical incapacity introducing highly effective doses of exotoxin A Pseudomonas overcomes the amount of cases of reaction destruction (44%). Conclusion. Exotoxin A Pseudomonas aeruginosa does not reveal a selective effect on the central nervous system and significant influence on physical efficiency of white rats.

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Systemic inflammatory response and cytokine profile at burn injury in dynamics

Year: 2017, volume 13 Issue: №2 Pages: 229-232
Heading: Physiology and Pathophysiology Article type: Original article
Authors: Morrison V.V., Bozhedomov A.Yu., Simonyan M.A., Morrison A.V.
Organization: Leningrad Regional Clinical Hospital, Saratov State Medical University
Summary:

The aim of the article is to study the dynamics of indices of systemic inflammation in correlation with the following factors: the outcome of the disease, disturbances in proinflammatory cytokines rate and vascular endothelial dysfunction markers rate at burn injury in dynamics. Material and Methods. 152 patients with burn injuries over 30 units by Frank's index were under the study. The research on the level of interleukins, endothelial vessels growth factor, macrophage chemotactic protein, level of endothelin and C-reactive protein was performed with quantitative immuno-enzymatic detection. The amount of circulating of desquamated endothelial cells was accounted by phase-contrast microscopy. Results. Proinflammatory cytokines rate and vascular endothelial dysfunction markers rate significantly increase reaching their maximum indices to the 7-15th day of burn injury and indicating the expressiveness of systemic inflammatory response syndrome. Conclusion. The received data have become important in the determination of increased number of criteria of systemic inflammatory response syndrome depending on the outcomes of the burn injury and endothelial dysfunction development.

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Botulinum toxin — therapeutic effect in cosmetology

Year: 2016, volume 12 Issue: №3 Pages: 521-524
Heading: Dermatovenerology Article type: Review
Authors: Morrison A.V., Bocharova Y.M., Morrison V.V.
Organization: clinic skin and venereal diseases, Saratov State Medical University
Summary:

This review presents the data from published literatures and the research works conducted by the authors about mechanisms of action of botulinum toxin and its use in the practical medicine (particularly in dermatology and cosmetology). Indications and contraindications of botulinum toxin use in cosmetology are also considered in this work.

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Ichthyosis: the question of inheritance

Year: 2016, volume 12 Issue: №3 Pages: 513-517
Heading: Dermatovenerology Article type: Review
Authors: Talnikova Е.Е., Sherstneva V.N., Morrison A.V., Utz S.R.
Organization: Saratov State Medical University
Summary:

This review summarizes the literature, specifically describing etiology, pathogenesis, classification and inheritance of ichthyosiform dermatoses. A case of ichthyosis vulgaris inherited in three generations of a family is described.

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